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PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 [ Homo sapiens (human) ]

Gene ID: 9677, updated on 23-Nov-2021

Summary

Official Symbol
PPIP5K1provided by HGNC
Official Full Name
diphosphoinositol pentakisphosphate kinase 1provided by HGNC
Primary source
HGNC:HGNC:29023
See related
Ensembl:ENSG00000168781 MIM:610979
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IP6K; IPS1; VIP1; hsVIP1; HISPPD2A
Summary
This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in duodenum (RPKM 8.8), small intestine (RPKM 8.2) and 25 other tissues See more
Orthologs
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Genomic context

See PPIP5K1 in Genome Data Viewer
Location:
15q15.3
Exon count:
35
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (43533475..43590272, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43825660..43882451, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex associated protein 4 Neighboring gene tumor protein p53 binding protein 1 Neighboring gene microtubule associated protein 1A Neighboring gene RNA, U6 small nuclear 554, pseudogene Neighboring gene creatine kinase, mitochondrial 1B Neighboring gene stereocilin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0377, MGC51871, DKFZp313L0221

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in inositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inositol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Names
IP6 kinase
VIP1 homolog
histidine acid phosphatase domain containing 2A
histidine acid phosphatase domain-containing protein 2A
inositol pyrophosphate synthase 1
insP6 and PP-IP5 kinase 1
NP_001124330.1
NP_001124331.1
NP_001177143.1
NP_001341311.1
NP_001341312.1
NP_001341313.1
NP_001341314.1
NP_001341315.1
NP_001341316.1
NP_001341317.1
NP_001341318.1
NP_001341319.1
NP_001341320.1
NP_001341321.1
NP_001341322.1
NP_001341323.1
NP_001341324.1
NP_001341325.1
NP_001341326.1
NP_001341327.1
NP_001341328.1
NP_001341329.1
NP_001341330.1
NP_001341331.1
NP_001380898.1
NP_001380899.1
NP_001380900.1
NP_001381324.1
NP_055474.3
XP_005254861.1
XP_006720849.1
XP_011520551.1
XP_011520552.1
XP_011520554.1
XP_011520556.1
XP_011520560.1
XP_016878224.1
XP_016878225.1
XP_016878226.1
XP_016878227.1
XP_016878230.1
XP_016878236.1
XP_016878237.1
XP_016878242.1
XP_016878243.1
XP_016878248.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_022929.1 RefSeqGene

    Range
    5001..61792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130858.4NP_001124330.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 5

    See identical proteins and their annotated locations for NP_001124330.1

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS45252.1
    UniProtKB/Swiss-Prot
    Q6PFW1
    Related
    ENSP00000400887.1, ENST00000420765.5
    Conserved Domains (1) summary
    pfam00328
    Location:390910
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  2. NM_001130859.3NP_001124331.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001124331.1

    Status: REVIEWED

    Source sequence(s)
    AC011330, BC057395, BX538022, DB065605
    Consensus CDS
    CCDS32215.1
    UniProtKB/Swiss-Prot
    Q6PFW1
    Related
    ENSP00000334779.4, ENST00000334933.8
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  3. NM_001190214.2NP_001177143.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 6

    See identical proteins and their annotated locations for NP_001177143.1

    Status: REVIEWED

    Source sequence(s)
    AB002375, AC011330, AC019011, AI638651, DB065605
    Consensus CDS
    CCDS53937.1
    UniProtKB/Swiss-Prot
    Q6PFW1
    Related
    ENSP00000353253.4, ENST00000360135.8
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  4. NM_001354382.3NP_001341311.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS86452.1
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  5. NM_001354383.2NP_001341312.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS86452.1
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  6. NM_001354384.2NP_001341313.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS86452.1
    Related
    ENSP00000371303.4, ENST00000381879.8
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  7. NM_001354385.2NP_001341314.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS86452.1
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  8. NM_001354386.2NP_001341315.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS86452.1
    Related
    ENSP00000371309.1, ENST00000381885.5
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  9. NM_001354387.2NP_001341316.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    pfam00328
    Location:390898
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  10. NM_001354388.2NP_001341317.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    pfam00328
    Location:390898
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  11. NM_001354389.2NP_001341318.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    pfam00328
    Location:390898
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  12. NM_001354390.2NP_001341319.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS32215.1
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  13. NM_001354391.2NP_001341320.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS32215.1
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  14. NM_001354392.2NP_001341321.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS32215.1
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  15. NM_001354393.2NP_001341322.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    pfam00328
    Location:390898
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  16. NM_001354394.2NP_001341323.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    pfam00328
    Location:390878
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  17. NM_001354395.2NP_001341324.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  18. NM_001354396.2NP_001341325.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  19. NM_001354397.2NP_001341326.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  20. NM_001354398.2NP_001341327.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    pfam00328
    Location:135651
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  21. NM_001354399.2NP_001341328.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    pfam00328
    Location:135651
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  22. NM_001354400.2NP_001341329.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    pfam00328
    Location:135651
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  23. NM_001354401.2NP_001341330.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (2) summary
    cl11399
    Location:5242
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cl27087
    Location:547654
    SPOR; Sporulation related domain
  24. NM_001354402.2NP_001341331.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (2) summary
    cl11399
    Location:5234
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cl27087
    Location:518625
    SPOR; Sporulation related domain
  25. NM_001393969.1NP_001380898.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (2) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
    pfam18086
    Location:55144
    PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
  26. NM_001393970.1NP_001380899.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (2) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
    pfam18086
    Location:55144
    PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
  27. NM_001393971.1NP_001380900.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    cd07061
    Location:525894
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
  28. NM_001394395.1NP_001381324.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (1) summary
    cd07061
    Location:525902
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
  29. NM_014659.6NP_055474.3  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_055474.3

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS32215.1
    UniProtKB/Swiss-Prot
    Q6PFW1
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    43533475..43590272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254804.1XP_005254861.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X6

    See identical proteins and their annotated locations for XP_005254861.1

    UniProtKB/Swiss-Prot
    Q6PFW1
    Related
    ENSP00000353446.4, ENST00000360301.8
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  2. XM_011522249.1XP_011520551.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_011520551.1

    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  3. XM_017022753.1XP_016878242.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X7

    Conserved Domains (1) summary
    pfam00328
    Location:390898
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  4. XM_011522252.1XP_011520554.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_011520554.1

    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  5. XM_011522254.1XP_011520556.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_011520556.1

    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  6. XM_011522250.1XP_011520552.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_011520552.1

    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  7. XM_017022737.1XP_016878226.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  8. XM_017022736.1XP_016878225.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  9. XM_017022735.1XP_016878224.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  10. XM_017022748.1XP_016878237.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X6

    UniProtKB/Swiss-Prot
    Q6PFW1
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  11. XM_017022741.1XP_016878230.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X4

    UniProtKB/TrEMBL
    B7WPL9
    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  12. XM_017022738.1XP_016878227.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X2

    Conserved Domains (1) summary
    pfam00328
    Location:390898
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  13. XM_017022747.1XP_016878236.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5

    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  14. XM_011522258.1XP_011520560.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

    Conserved Domains (1) summary
    pfam00328
    Location:135651
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  15. XM_017022754.1XP_016878243.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  16. XM_006720786.2XP_006720849.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

    Conserved Domains (1) summary
    pfam00328
    Location:390906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  17. XM_017022759.1XP_016878248.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X10

    UniProtKB/Swiss-Prot
    Q6PFW1
    Related
    ENST00000488768.5
    Conserved Domains (1) summary
    pfam00328
    Location:390807
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024463.3: Suppressed sequence

    Description
    NM_001024463.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns to the reference genome with non-consensus splice sites.
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