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WSCD2 WSC domain containing 2 [ Homo sapiens (human) ]

Gene ID: 9671, updated on 1-Jun-2020

Summary

Official Symbol
WSCD2provided by HGNC
Official Full Name
WSC domain containing 2provided by HGNC
Primary source
HGNC:HGNC:29117
See related
Ensembl:ENSG00000075035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in thyroid (RPKM 7.6), brain (RPKM 4.6) and 4 other tissues See more
Orthologs

Genomic context

See WSCD2 in Genome Data Viewer
Location:
12q23.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (108129288..108250537)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (108523511..108644314)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369964 Neighboring gene programmed cell death 2 pseudogene Neighboring gene uncharacterized LOC105369965 Neighboring gene DNA dC->dU-editing enzyme APOBEC-3G-like Neighboring gene Sharpr-MPRA regulatory region 8395 Neighboring gene chemerin chemokine-like receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog
Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.
NHGRI GWA Catalog

General gene information

Markers

Homology

Clone Names

  • FLJ40750, FLJ54414, KIAA0789, MGC117165, MGC168300, MGC168301, DKFZp686E1293

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WSC domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304447.2NP_001291376.1  WSC domain-containing protein 2

    See identical proteins and their annotated locations for NP_001291376.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC009729, BX647283
    Consensus CDS
    CCDS41828.1
    UniProtKB/Swiss-Prot
    Q2TBF2
    Related
    ENSP00000331933.4, ENST00000332082.8
    Conserved Domains (2) summary
    smart00321
    Location:127219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415507
    Sulfotransfer_1; Sulfotransferase domain
  2. NM_014653.4NP_055468.2  WSC domain-containing protein 2

    See identical proteins and their annotated locations for NP_055468.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC009729, BC110330, BX647283, DA095713
    Consensus CDS
    CCDS41828.1
    UniProtKB/Swiss-Prot
    Q2TBF2
    Related
    ENSP00000448047.1, ENST00000547525.6
    Conserved Domains (2) summary
    smart00321
    Location:127219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415507
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    108129288..108250537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020244.1XP_016875733.1  WSC domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q2TBF2
    Conserved Domains (2) summary
    smart00321
    Location:127219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415507
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_017020249.1XP_016875738.1  WSC domain-containing protein 2 isoform X2

  3. XM_017020243.1XP_016875732.1  WSC domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q2TBF2
    Conserved Domains (2) summary
    smart00321
    Location:127219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415507
    Sulfotransfer_1; Sulfotransferase domain
  4. XM_017020248.1XP_016875737.1  WSC domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q2TBF2
    Conserved Domains (2) summary
    smart00321
    Location:127219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415507
    Sulfotransfer_1; Sulfotransferase domain
  5. XM_017020252.1XP_016875741.1  WSC domain-containing protein 2 isoform X2

  6. XM_017020250.2XP_016875739.1  WSC domain-containing protein 2 isoform X2

  7. XM_017020247.1XP_016875736.1  WSC domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q2TBF2
    Conserved Domains (2) summary
    smart00321
    Location:127219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415507
    Sulfotransfer_1; Sulfotransferase domain
  8. XM_017020246.2XP_016875735.1  WSC domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q2TBF2
    Related
    ENSP00000447272.1, ENST00000549903.1
    Conserved Domains (2) summary
    smart00321
    Location:127219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415507
    Sulfotransfer_1; Sulfotransferase domain
  9. XM_017020245.1XP_016875734.1  WSC domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q2TBF2
    Conserved Domains (2) summary
    smart00321
    Location:127219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415507
    Sulfotransfer_1; Sulfotransferase domain
  10. XM_017020251.2XP_016875740.1  WSC domain-containing protein 2 isoform X2

RNA

  1. XR_944841.2 RNA Sequence

  2. XR_001748924.2 RNA Sequence

  3. XR_001748926.2 RNA Sequence

  4. XR_001748925.2 RNA Sequence

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