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SAFB2 scaffold attachment factor B2 [ Homo sapiens (human) ]

Gene ID: 9667, updated on 5-Dec-2021

Summary

Official Symbol
SAFB2provided by HGNC
Official Full Name
scaffold attachment factor B2provided by HGNC
Primary source
HGNC:HGNC:21605
See related
Ensembl:ENSG00000130254 MIM:608066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in kidney (RPKM 19.8), spleen (RPKM 18.1) and 25 other tissues See more
Orthologs
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Genomic context

See SAFB2 in Genome Data Viewer
Location:
19p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (5586993..5622846, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5587010..5622787, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SNRPE pseudogene 4 Neighboring gene Sharpr-MPRA regulatory regions 733 and 12449 Neighboring gene scaffold attachment factor B Neighboring gene uncharacterized LOC107985320

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0138

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Sertoli cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of androgen receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
scaffold attachment factor B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050735.1 RefSeqGene

    Range
    5152..40929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014649.3NP_055464.1  scaffold attachment factor B2

    See identical proteins and their annotated locations for NP_055464.1

    Status: REVIEWED

    Source sequence(s)
    AW136754, D50928, DB475007
    Consensus CDS
    CCDS32879.1
    UniProtKB/Swiss-Prot
    Q14151
    Related
    ENSP00000252542.3, ENST00000252542.9
    Conserved Domains (3) summary
    smart00513
    Location:3064
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    COG0724
    Location:336512
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12679
    Location:406481
    RRM_SAFB1_SAFB2; RNA recognition motif in scaffold attachment factor B1 (SAFB1), scaffold attachment factor B2 (SAFB2), and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    5586993..5622846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451802.1XP_024307570.1  scaffold attachment factor B2 isoform X3

    Conserved Domains (1) summary
    cd12679
    Location:1792
    RRM_SAFB1_SAFB2; RNA recognition motif in scaffold attachment factor B1 (SAFB1), scaffold attachment factor B2 (SAFB2), and similar proteins
  2. XM_024451803.1XP_024307571.1  scaffold attachment factor B2 isoform X4

    Conserved Domains (1) summary
    cl17169
    Location:127
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_017027520.2XP_016883009.1  scaffold attachment factor B2 isoform X4

    Conserved Domains (1) summary
    cl17169
    Location:127
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_017027522.2XP_016883011.1  scaffold attachment factor B2 isoform X4

    Conserved Domains (1) summary
    cl17169
    Location:127
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_024451804.1XP_024307572.1  scaffold attachment factor B2 isoform X4

    Conserved Domains (1) summary
    cl17169
    Location:127
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. XM_024451805.1XP_024307573.1  scaffold attachment factor B2 isoform X4

    Conserved Domains (1) summary
    cl17169
    Location:127
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. XM_011528450.3XP_011526752.1  scaffold attachment factor B2 isoform X4

    See identical proteins and their annotated locations for XP_011526752.1

    Conserved Domains (1) summary
    cl17169
    Location:127
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. XM_024451801.1XP_024307569.1  scaffold attachment factor B2 isoform X2

    Conserved Domains (1) summary
    cd12679
    Location:26101
    RRM_SAFB1_SAFB2; RNA recognition motif in scaffold attachment factor B1 (SAFB1), scaffold attachment factor B2 (SAFB2), and similar proteins
  9. XM_011528449.3XP_011526751.1  scaffold attachment factor B2 isoform X1

    Conserved Domains (4) summary
    smart00513
    Location:3064
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    COG0724
    Location:336512
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12679
    Location:406481
    RRM_SAFB1_SAFB2; RNA recognition motif in scaffold attachment factor B1 (SAFB1), scaffold attachment factor B2 (SAFB2), and similar proteins
    pfam08648
    Location:724820
    DUF1777; Protein of unknown function (DUF1777)
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