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DZIP3 DAZ interacting zinc finger protein 3 [ Homo sapiens (human) ]

Gene ID: 9666, updated on 9-Aug-2020

Summary

Official Symbol
DZIP3provided by HGNC
Official Full Name
DAZ interacting zinc finger protein 3provided by HGNC
Primary source
HGNC:HGNC:30938
See related
Ensembl:ENSG00000198919 MIM:608672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UURF2; PPP1R66; hRUL138
Expression
Broad expression in testis (RPKM 21.6), brain (RPKM 12.1) and 21 other tissues See more
Orthologs

Genomic context

See DZIP3 in Genome Data Viewer
Location:
3q13.13
Exon count:
36
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (108589490..108694840)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108308337..108413693)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 15 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene cellular inhibitor of PP2A Neighboring gene uncharacterized LOC105374033 Neighboring gene uncharacterized LOC105374034

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13327, FLJ57977, FLJ58022, FLJ58223, KIAA0675

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase DZIP3
Names
DAZ interacting protein 3, zinc finger
DAZ-interacting protein 3
RING-type E3 ubiquitin transferase DZIP3
RNA-binding RING-H2 protein-ubiquitin ligase
RNA-binding ubiquitin ligase of 138 kDa
UURF2 ubiquitin ligase
human RNA-binding ubiquitin ligase of 138 kDa
protein phosphatase 1, regulatory subunit 66
zinc finger DAZ interacting protein 3
NP_055463.1
XP_005247971.1
XP_005247972.1
XP_005247973.1
XP_005247974.1
XP_005247975.1
XP_005247976.1
XP_016863029.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014648.4NP_055463.1  E3 ubiquitin-protein ligase DZIP3

    See identical proteins and their annotated locations for NP_055463.1

    Status: VALIDATED

    Source sequence(s)
    AC092185, AC092693
    Consensus CDS
    CCDS2952.1
    UniProtKB/Swiss-Prot
    Q86Y13
    Related
    ENSP00000355028.3, ENST00000361582.8
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    108589490..108694840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247918.3XP_005247975.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247975.1

    UniProtKB/Swiss-Prot
    Q86Y13
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_005247917.3XP_005247974.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247974.1

    UniProtKB/Swiss-Prot
    Q86Y13
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_005247919.4XP_005247976.1  E3 ubiquitin-protein ligase DZIP3 isoform X2

    Conserved Domains (2) summary
    pfam12678
    Location:941982
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:942982
    zf-RING_2; Ring finger domain
  4. XM_005247914.4XP_005247971.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247971.1

    UniProtKB/Swiss-Prot
    Q86Y13
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_017007540.1XP_016863029.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    Q86Y13
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_005247915.3XP_005247972.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247972.1

    UniProtKB/Swiss-Prot
    Q86Y13
    Related
    ENSP00000419981.1, ENST00000463306.1
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_005247916.3XP_005247973.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247973.1

    UniProtKB/Swiss-Prot
    Q86Y13
    Conserved Domains (2) summary
    cd16460
    Location:11471188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675856
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. XR_924222.2 RNA Sequence

  2. XR_001740382.1 RNA Sequence

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