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HS2ST1 heparan sulfate 2-O-sulfotransferase 1 [ Homo sapiens (human) ]

Gene ID: 9653, updated on 11-Jun-2025
Official Symbol
HS2ST1provided by HGNC
Official Full Name
heparan sulfate 2-O-sulfotransferase 1provided by HGNC
Primary source
HGNC:HGNC:5193
See related
Ensembl:ENSG00000153936 MIM:604844; AllianceGenome:HGNC:5193
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NFSRA; dJ604K5.2
Summary
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in adrenal (RPKM 13.4), thyroid (RPKM 7.8) and 25 other tissues See more
Orthologs
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See HS2ST1 in Genome Data Viewer
Location:
1p22.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (86914635..87109982)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (86755193..86952707)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (87380318..87575665)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1281 Neighboring gene selenoprotein F Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:87379106-87379720 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:87379721-87380335 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:87389203-87389381 Neighboring gene uncharacterized LOC124904211 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:87482946-87483115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1285 Neighboring gene ubiquitin like modifier activating enzyme 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1286 Neighboring gene ubiquitin like modifier activating enzyme 2 pseudogene Neighboring gene long intergenic non-protein coding RNA 1140 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:87612561-87613060 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:87614396-87615060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:87616858-87617456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:87617457-87618055 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:87666183-87666684 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:87666685-87667184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1287 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1043 Neighboring gene long intergenic non-protein coding RNA 2801

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ11317, KIAA0448, MGC131986

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heparan sulfate 2-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heparan sulfate 2-sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables heparan sulfate 2-sulfotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables heparan sulfate 2-sulfotransferase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
heparan sulfate 2-O-sulfotransferase 1
Names
2-O-sulfotransferase
2OST
NP_001127964.1
NP_036394.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134492.2NP_001127964.1  heparan sulfate 2-O-sulfotransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001127964.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 3' coding region and lacks some coding region segments, compared to variant 1. The resulting protein (isoform 2) has a shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC093155, AL121989, BC025384, BC108735
    Consensus CDS
    CCDS44171.1
    UniProtKB/TrEMBL
    A0A8I5KR52
    Related
    ENSP00000359582.3, ENST00000370551.8
    Conserved Domains (1) summary
    pfam03567
    Location:71224
    Sulfotransfer_2; Sulfotransferase family
  2. NM_012262.4NP_036394.1  heparan sulfate 2-O-sulfotransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_036394.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AB007917, AC093155, AL121989, BC025990, BF431947
    Consensus CDS
    CCDS711.1
    UniProtKB/Swiss-Prot
    D3DT22, O75036, Q32NB5, Q7LGA3, Q8TAC5, Q9H441, Q9NUJ9
    UniProtKB/TrEMBL
    B3KN15
    Related
    ENSP00000359581.4, ENST00000370550.10
    Conserved Domains (1) summary
    pfam03567
    Location:71326
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    86914635..87109982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    86755193..86952707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)