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PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F [ Homo sapiens (human) ]

Gene ID: 9647, updated on 18-Sep-2024

Summary

Official Symbol
PPM1Fprovided by HGNC
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1Fprovided by HGNC
Primary source
HGNC:HGNC:19388
See related
Ensembl:ENSG00000100034 MIM:619309; AllianceGenome:HGNC:19388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMKP; FEM-2; POPX2; hFEM-2; CaMKPase
Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 16.9), spleen (RPKM 14.5) and 24 other tissues See more
Orthologs
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Genomic context

See PPM1F in Genome Data Viewer
Location:
22q11.22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (21919425..21952848, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (22332962..22366379, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22273798..22307220, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:22145734-22146933 Neighboring gene MPRA-validated peak4466 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr22:22165820-22166034 Neighboring gene Sharpr-MPRA regulatory region 14215 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:22192349-22192556 Neighboring gene RNA, 5S ribosomal pseudogene 493 Neighboring gene MPRA-validated peak4467 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22210131-22210632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13517 Neighboring gene mitogen-activated protein kinase 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:22237113-22237874 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63076 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:22254563-22254749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22271290-22272100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22274276-22274935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22275597-22276255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22292226-22293032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22293841-22294647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22293033-22293840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22298307-22298806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22306489-22307009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22318681-22319182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22319183-22319682 Neighboring gene MPPE1 pseudogene 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63111 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22336585-22337571 Neighboring gene PPM1F antisense RNA 1 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr22:22372768-22373375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18713 Neighboring gene PRAME N-terminal like, pseudogene Neighboring gene DNA topoisomerase III beta Neighboring gene immunoglobulin lambda variable (I)-70 (pseudogene) Neighboring gene immunoglobulin lambda locus

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat downregulates the expression of many proteins, including protein phosphatase 1F (KIAA0015), in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0015

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell-cell adhesion mediated by cadherin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of stress fiber assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 1F
Names
Ca(2+)/calmodulin-dependent protein kinase phosphatase
CaM-kinase phosphatase
PP2C phosphatase
partner of PIX 2
protein fem-2 homolog
protein phosphatase 1F (PP2C domain containing)
NP_001397765.1
NP_055449.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410836.1NP_001397765.1  protein phosphatase 1F isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC245452
    Consensus CDS
    CCDS93128.1
    UniProtKB/TrEMBL
    B3KX06, B5MCT7
    Related
    ENSP00000384930.1, ENST00000407142.5
  2. NM_014634.4NP_055449.1  protein phosphatase 1F isoform 1

    See identical proteins and their annotated locations for NP_055449.1

    Status: REVIEWED

    Source sequence(s)
    AC245452, AK291628, N34773
    Consensus CDS
    CCDS13796.1
    UniProtKB/Swiss-Prot
    A8K6G3, B7Z2C3, P49593, Q96PM2
    UniProtKB/TrEMBL
    Q6IPC0
    Related
    ENSP00000263212.5, ENST00000263212.10
    Conserved Domains (1) summary
    pfam00481
    Location:155406
    PP2C; Protein phosphatase 2C

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    21919425..21952848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    22332962..22366379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)