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PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F [ Homo sapiens (human) ]

Gene ID: 9647, updated on 17-Jun-2019

Summary

Official Symbol
PPM1Fprovided by HGNC
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1Fprovided by HGNC
Primary source
HGNC:HGNC:19388
See related
Ensembl:ENSG00000100034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMKP; FEM-2; POPX2; hFEM-2; CaMKPase
Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 16.9), spleen (RPKM 14.5) and 24 other tissues See more
Orthologs

Genomic context

See PPM1F in Genome Data Viewer
Location:
22q11.22
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (21919419..21952875, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22273792..22307250, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 280, pseudogene Neighboring gene yippee like 1 Neighboring gene RNA, 5S ribosomal pseudogene 493 Neighboring gene mitogen-activated protein kinase 1 Neighboring gene uncharacterized LOC100286925 Neighboring gene Sharpr-MPRA regulatory region 76 Neighboring gene DNA topoisomerase III beta Neighboring gene PRAME N-terminal like, pseudogene Neighboring gene immunoglobulin lambda variable (I)-70 (pseudogene) Neighboring gene immunoglobulin lambda locus

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat downregulates the expression of many proteins, including protein phosphatase 1F (KIAA0015), in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calmodulin-dependent protein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
magnesium-dependent protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cellular response to drug IDA
Inferred from Direct Assay
more info
PubMed 
histone dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell-cell adhesion mediated by cadherin IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity by regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of stress fiber assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 1F
Names
Ca(2+)/calmodulin-dependent protein kinase phosphatase
CaM-kinase phosphatase
PP2C phosphatase
partner of PIX 2
protein fem-2 homolog
protein phosphatase 1F (PP2C domain containing)
NP_055449.1
XP_011528858.1
XP_016884597.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014634.4NP_055449.1  protein phosphatase 1F

    See identical proteins and their annotated locations for NP_055449.1

    Status: REVIEWED

    Source sequence(s)
    AC245452, AK291628, N34773
    Consensus CDS
    CCDS13796.1
    UniProtKB/Swiss-Prot
    P49593
    Related
    ENSP00000263212.5, ENST00000263212.10
    Conserved Domains (1) summary
    pfam00481
    Location:155406
    PP2C; Protein phosphatase 2C

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    21919419..21952875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530556.1XP_011528858.1  protein phosphatase 1F isoform X1

    See identical proteins and their annotated locations for XP_011528858.1

    UniProtKB/TrEMBL
    B5MCT7
    Related
    ENSP00000384930.1, ENST00000407142.5
    Conserved Domains (1) summary
    pfam00481
    Location:1238
    PP2C; Protein phosphatase 2C
  2. XM_017029108.2XP_016884597.1  protein phosphatase 1F isoform X2

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