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FNIP1 folliculin interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 96459, updated on 12-Oct-2019

Summary

Official Symbol
FNIP1provided by HGNC
Official Full Name
folliculin interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:29418
See related
Ensembl:ENSG00000217128 MIM:610594
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in testis (RPKM 9.3), thyroid (RPKM 7.7) and 25 other tissues See more
Orthologs

Genomic context

See FNIP1 in Genome Data Viewer
Location:
5q31.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (131641714..131797017, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (130977407..131132756, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CDC42 small effector 2 Neighboring gene uncharacterized LOC105379173 Neighboring gene Rap guanine nucleotide exchange factor 6 Neighboring gene ACTB pseudogene 4 Neighboring gene meiotic kinetochore factor Neighboring gene acyl-CoA synthetase long chain family member 6 Neighboring gene ACSL6 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with folliculin interacting protein 1 (FNIP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC667, KIAA1961, DKFZp781P0215, DKFZp686E18167

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
immature B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of B cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of pro-B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
folliculin-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008738.3NP_001008738.3  folliculin-interacting protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC005593, AC008695
    Consensus CDS
    CCDS34226.1
    Related
    ENSP00000309266.7, ENST00000307968.11
  2. NM_001346113.2NP_001333042.2  folliculin-interacting protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' structure compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC005593, AC008695
    Consensus CDS
    CCDS87321.1
    Related
    ENSP00000425619.1, ENST00000511848.1
  3. NM_001346114.2NP_001333043.1  folliculin-interacting protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC005593, AC008695, CA449088, CR936723
    Consensus CDS
    CCDS87320.1
    UniProtKB/TrEMBL
    J3KNG8
    Related
    ENSP00000310453.8, ENST00000307954.12
  4. NM_133372.3NP_588613.3  folliculin-interacting protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC005593, AC008695
    Consensus CDS
    CCDS34227.1
    Related
    ENSP00000421985.1, ENST00000510461.6
    Conserved Domains (3) summary
    pfam14636
    Location:41155
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:316548
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:9761162
    FNIP_C; Folliculin-interacting protein C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    131641714..131797017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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