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ARHGEF10 Rho guanine nucleotide exchange factor 10 [ Homo sapiens (human) ]

Gene ID: 9639, updated on 17-Apr-2025

Summary

Official Symbol
ARHGEF10provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 10provided by HGNC
Primary source
HGNC:HGNC:14103
See related
Ensembl:ENSG00000104728 MIM:608136; AllianceGenome:HGNC:14103
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNCV; GEF10
Summary
This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Broad expression in testis (RPKM 15.4), lung (RPKM 12.1) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ARHGEF10 in Genome Data Viewer
Location:
8p23.3
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (1823300..1958641)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (1601800..1736745)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (1772092..1906807)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1762347-1762848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1762849-1763348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1764028-1764696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1764697-1765364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1776960-1777876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1777877-1778792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1781498-1781998 Neighboring gene microRNA 596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1783384-1783975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1788613-1789492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1789493-1790372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1790373-1791250 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1791725-1792924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1813026-1813858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1821545-1822256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1829183-1829682 Neighboring gene Sharpr-MPRA regulatory region 1960 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:1854442-1855641 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:1856650-1856751 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1859957-1860559 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:1864189-1864688 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1870370-1871569 Neighboring gene uncharacterized LOC100131395 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:1894594-1894745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1897836-1898336 Neighboring gene KBTBD11 antisense RNA 1 Neighboring gene KBTBD11 overlapping transcript 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1926153-1926712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1926713-1927271 Neighboring gene kelch repeat and BTB domain containing 11

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Autosomal dominant slowed nerve conduction velocity
MedGen: C1842357 OMIM: 608236 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
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EBI GWAS Catalog
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EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC131664, DKFZp686H0726

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 10
Names
Rho guanine nucleotide exchange factor (GEF) 10

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008480.1 RefSeqGene

    Range
    5001..139659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_234

mRNA and Protein(s)

  1. NM_001308152.2NP_001295081.1  rho guanine nucleotide exchange factor 10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA758332, AB002292, AC019257, BC112926
    Consensus CDS
    CCDS78297.1
    UniProtKB/TrEMBL
    A0A2X0U4L4
    Related
    ENSP00000427909.1, ENST00000520359.5
    Conserved Domains (2) summary
    pfam00621
    Location:366544
    RhoGEF; RhoGEF domain
    cl17171
    Location:576640
    PH-like; Pleckstrin homology-like domain
  2. NM_001308153.3NP_001295082.2  rho guanine nucleotide exchange factor 10 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC019257
    Consensus CDS
    CCDS78296.1
    Related
    ENSP00000431012.1, ENST00000518288.5
  3. NM_001438091.1NP_001425020.1  rho guanine nucleotide exchange factor 10 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC019257
  4. NM_001438092.1NP_001425021.1  rho guanine nucleotide exchange factor 10 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC019257
  5. NM_001438093.1NP_001425022.1  rho guanine nucleotide exchange factor 10 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC019257
  6. NM_001438094.1NP_001425023.1  rho guanine nucleotide exchange factor 10 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC019257
  7. NM_014629.4NP_055444.2  rho guanine nucleotide exchange factor 10 isoform 1

    See identical proteins and their annotated locations for NP_055444.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AA758332, AB002292, AC019257, AI348138, CN307765
    Consensus CDS
    CCDS34794.1
    UniProtKB/TrEMBL
    A0A2X0U4L4
    Related
    ENSP00000340297.3, ENST00000349830.8
    Conserved Domains (2) summary
    pfam00621
    Location:404582
    RhoGEF; RhoGEF domain
    cl17171
    Location:614678
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    1823300..1958641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422457.1XP_047278413.1  rho guanine nucleotide exchange factor 10 isoform X10

    UniProtKB/TrEMBL
    A0A2X0U4L4
  2. XM_047422452.1XP_047278408.1  rho guanine nucleotide exchange factor 10 isoform X7

    UniProtKB/TrEMBL
    A0A2X0U4L4
  3. XM_047422450.1XP_047278406.1  rho guanine nucleotide exchange factor 10 isoform X4

    UniProtKB/TrEMBL
    A0A2X0U4L4
  4. XM_047422454.1XP_047278410.1  rho guanine nucleotide exchange factor 10 isoform X3

    UniProtKB/TrEMBL
    A0A2X0U4L4
  5. XM_047422456.1XP_047278412.1  rho guanine nucleotide exchange factor 10 isoform X9

    UniProtKB/TrEMBL
    A0A2X0U4L4
  6. XM_047422461.1XP_047278417.1  rho guanine nucleotide exchange factor 10 isoform X15

    UniProtKB/TrEMBL
    A0A2X0U4L4
  7. XM_005266041.5XP_005266098.1  rho guanine nucleotide exchange factor 10 isoform X4

    UniProtKB/TrEMBL
    A0A2X0U4L4
    Conserved Domains (3) summary
    cd00160
    Location:398582
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    PTZ00441
    Location:3250
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cl17171
    Location:615679
    PH-like; Pleckstrin homology-like domain
  8. XM_047422459.1XP_047278415.1  rho guanine nucleotide exchange factor 10 isoform X12

    UniProtKB/TrEMBL
    A0A2X0U4L4
  9. XM_047422455.1XP_047278411.1  rho guanine nucleotide exchange factor 10 isoform X9

    UniProtKB/TrEMBL
    A0A2X0U4L4
  10. XM_047422458.1XP_047278414.1  rho guanine nucleotide exchange factor 10 isoform X11

    UniProtKB/TrEMBL
    A0A2X0U4L4
  11. XM_017014003.2XP_016869492.1  rho guanine nucleotide exchange factor 10 isoform X2

    UniProtKB/Swiss-Prot
    O14665, O15013, Q2KHR8, Q68D55, Q8IWD9, Q8IY77
    UniProtKB/TrEMBL
    A0A2X0U4L4
    Related
    ENSP00000381571.1, ENST00000398564.5
    Conserved Domains (2) summary
    pfam00621
    Location:429607
    RhoGEF; RhoGEF domain
    cl17171
    Location:639703
    PH-like; Pleckstrin homology-like domain
  12. XM_047422449.1XP_047278405.1  rho guanine nucleotide exchange factor 10 isoform X3

    UniProtKB/TrEMBL
    A0A2X0U4L4
  13. XM_024447335.2XP_024303103.1  rho guanine nucleotide exchange factor 10 isoform X1

    UniProtKB/TrEMBL
    A0A2X0U4L4
    Conserved Domains (3) summary
    cd00160
    Location:426610
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    PTZ00441
    Location:27278
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cl17171
    Location:643707
    PH-like; Pleckstrin homology-like domain
  14. XM_047422453.1XP_047278409.1  rho guanine nucleotide exchange factor 10 isoform X8

    UniProtKB/TrEMBL
    A0A2X0U4L4
  15. XM_011534768.1XP_011533070.1  rho guanine nucleotide exchange factor 10 isoform X6

    See identical proteins and their annotated locations for XP_011533070.1

    UniProtKB/TrEMBL
    A0A2X0U4L4
    Conserved Domains (2) summary
    pfam00621
    Location:405583
    RhoGEF; RhoGEF domain
    cl17171
    Location:615679
    PH-like; Pleckstrin homology-like domain
  16. XM_047422451.1XP_047278407.1  rho guanine nucleotide exchange factor 10 isoform X5

    UniProtKB/TrEMBL
    A0A2X0U4L4
  17. XM_011534770.3XP_011533072.1  rho guanine nucleotide exchange factor 10 isoform X13

    See identical proteins and their annotated locations for XP_011533072.1

    UniProtKB/TrEMBL
    A0A2X0U4L4
    Conserved Domains (2) summary
    pfam00621
    Location:405583
    RhoGEF; RhoGEF domain
    cl17171
    Location:615679
    PH-like; Pleckstrin homology-like domain
  18. XM_047422460.1XP_047278416.1  rho guanine nucleotide exchange factor 10 isoform X14

    UniProtKB/TrEMBL
    A0A2X0U4L4
  19. XM_047422462.1XP_047278418.1  rho guanine nucleotide exchange factor 10 isoform X16

    UniProtKB/TrEMBL
    H0YAN8
    Related
    ENSP00000427768.1, ENST00000522435.5

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187576.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    6676..142017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328834.1XP_054184809.1  rho guanine nucleotide exchange factor 10 isoform X10

    UniProtKB/TrEMBL
    A0A2X0U4L4
  2. XM_054328829.1XP_054184804.1  rho guanine nucleotide exchange factor 10 isoform X7

    UniProtKB/TrEMBL
    A0A2X0U4L4
  3. XM_054328826.1XP_054184801.1  rho guanine nucleotide exchange factor 10 isoform X4

    UniProtKB/TrEMBL
    A0A2X0U4L4
  4. XM_054328831.1XP_054184806.1  rho guanine nucleotide exchange factor 10 isoform X3

    UniProtKB/TrEMBL
    A0A2X0U4L4
  5. XM_054328833.1XP_054184808.1  rho guanine nucleotide exchange factor 10 isoform X9

    UniProtKB/TrEMBL
    A0A2X0U4L4
  6. XM_054328839.1XP_054184814.1  rho guanine nucleotide exchange factor 10 isoform X15

    UniProtKB/TrEMBL
    A0A2X0U4L4
  7. XM_054328825.1XP_054184800.1  rho guanine nucleotide exchange factor 10 isoform X4

    UniProtKB/TrEMBL
    A0A2X0U4L4
  8. XM_054328836.1XP_054184811.1  rho guanine nucleotide exchange factor 10 isoform X12

    UniProtKB/TrEMBL
    A0A2X0U4L4
  9. XM_054328832.1XP_054184807.1  rho guanine nucleotide exchange factor 10 isoform X9

    UniProtKB/TrEMBL
    A0A2X0U4L4
  10. XM_054328835.1XP_054184810.1  rho guanine nucleotide exchange factor 10 isoform X11

    UniProtKB/TrEMBL
    A0A2X0U4L4
  11. XM_054328823.1XP_054184798.1  rho guanine nucleotide exchange factor 10 isoform X2

    UniProtKB/Swiss-Prot
    O14665, O15013, Q2KHR8, Q68D55, Q8IWD9, Q8IY77
    UniProtKB/TrEMBL
    A0A2X0U4L4
  12. XM_054328824.1XP_054184799.1  rho guanine nucleotide exchange factor 10 isoform X3

    UniProtKB/TrEMBL
    A0A2X0U4L4
  13. XM_054328822.1XP_054184797.1  rho guanine nucleotide exchange factor 10 isoform X1

    UniProtKB/TrEMBL
    A0A2X0U4L4
  14. XM_054328830.1XP_054184805.1  rho guanine nucleotide exchange factor 10 isoform X8

    UniProtKB/TrEMBL
    A0A2X0U4L4
  15. XM_054328828.1XP_054184803.1  rho guanine nucleotide exchange factor 10 isoform X6

    UniProtKB/TrEMBL
    A0A2X0U4L4
  16. XM_054328827.1XP_054184802.1  rho guanine nucleotide exchange factor 10 isoform X5

    UniProtKB/TrEMBL
    A0A2X0U4L4
  17. XM_054328837.1XP_054184812.1  rho guanine nucleotide exchange factor 10 isoform X13

    UniProtKB/TrEMBL
    A0A2X0U4L4
  18. XM_054328838.1XP_054184813.1  rho guanine nucleotide exchange factor 10 isoform X14

    UniProtKB/TrEMBL
    A0A2X0U4L4
  19. XM_054328840.1XP_054184815.1  rho guanine nucleotide exchange factor 10 isoform X16

    UniProtKB/TrEMBL
    H0YAN8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    1601800..1736745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361550.1XP_054217525.1  rho guanine nucleotide exchange factor 10 isoform X10

    UniProtKB/TrEMBL
    A0A2X0U4L4
  2. XM_054361545.1XP_054217520.1  rho guanine nucleotide exchange factor 10 isoform X7

    UniProtKB/TrEMBL
    A0A2X0U4L4
  3. XM_054361542.1XP_054217517.1  rho guanine nucleotide exchange factor 10 isoform X4

    UniProtKB/TrEMBL
    A0A2X0U4L4
  4. XM_054361547.1XP_054217522.1  rho guanine nucleotide exchange factor 10 isoform X3

    UniProtKB/TrEMBL
    A0A2X0U4L4
  5. XM_054361549.1XP_054217524.1  rho guanine nucleotide exchange factor 10 isoform X9

    UniProtKB/TrEMBL
    A0A2X0U4L4
  6. XM_054361555.1XP_054217530.1  rho guanine nucleotide exchange factor 10 isoform X15

    UniProtKB/TrEMBL
    A0A2X0U4L4
  7. XM_054361541.1XP_054217516.1  rho guanine nucleotide exchange factor 10 isoform X4

    UniProtKB/TrEMBL
    A0A2X0U4L4
  8. XM_054361552.1XP_054217527.1  rho guanine nucleotide exchange factor 10 isoform X12

    UniProtKB/TrEMBL
    A0A2X0U4L4
  9. XM_054361548.1XP_054217523.1  rho guanine nucleotide exchange factor 10 isoform X9

    UniProtKB/TrEMBL
    A0A2X0U4L4
  10. XM_054361551.1XP_054217526.1  rho guanine nucleotide exchange factor 10 isoform X11

    UniProtKB/TrEMBL
    A0A2X0U4L4
  11. XM_054361539.1XP_054217514.1  rho guanine nucleotide exchange factor 10 isoform X2

    UniProtKB/Swiss-Prot
    O14665, O15013, Q2KHR8, Q68D55, Q8IWD9, Q8IY77
    UniProtKB/TrEMBL
    A0A2X0U4L4
  12. XM_054361540.1XP_054217515.1  rho guanine nucleotide exchange factor 10 isoform X3

    UniProtKB/TrEMBL
    A0A2X0U4L4
  13. XM_054361538.1XP_054217513.1  rho guanine nucleotide exchange factor 10 isoform X1

    UniProtKB/TrEMBL
    A0A2X0U4L4
  14. XM_054361546.1XP_054217521.1  rho guanine nucleotide exchange factor 10 isoform X8

    UniProtKB/TrEMBL
    A0A2X0U4L4
  15. XM_054361544.1XP_054217519.1  rho guanine nucleotide exchange factor 10 isoform X6

    UniProtKB/TrEMBL
    A0A2X0U4L4
  16. XM_054361543.1XP_054217518.1  rho guanine nucleotide exchange factor 10 isoform X5

    UniProtKB/TrEMBL
    A0A2X0U4L4
  17. XM_054361553.1XP_054217528.1  rho guanine nucleotide exchange factor 10 isoform X13

    UniProtKB/TrEMBL
    A0A2X0U4L4
  18. XM_054361554.1XP_054217529.1  rho guanine nucleotide exchange factor 10 isoform X14

    UniProtKB/TrEMBL
    A0A2X0U4L4
  19. XM_054361556.1XP_054217531.1  rho guanine nucleotide exchange factor 10 isoform X16

    UniProtKB/TrEMBL
    H0YAN8

RNA

  1. XR_008487897.1 RNA Sequence