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FEZ2 fasciculation and elongation protein zeta 2 [ Homo sapiens (human) ]

Gene ID: 9637, updated on 21-Dec-2019

Summary

Official Symbol
FEZ2provided by HGNC
Official Full Name
fasciculation and elongation protein zeta 2provided by HGNC
Primary source
HGNC:HGNC:3660
See related
Ensembl:ENSG00000171055 MIM:604826
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUM3CL
Summary
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 32.7), brain (RPKM 29.1) and 24 other tissues See more
Orthologs

Genomic context

See FEZ2 in Genome Data Viewer
Location:
2p22.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (36552239..36598190, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (36779397..36825333, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CRIM1 divergent transcript Neighboring gene cysteine rich transmembrane BMP regulator 1 Neighboring gene receptor for activated C kinase 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 2322

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117372

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon guidance TAS
Traceable Author Statement
more info
PubMed 
negative regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fasciculation and elongation protein zeta-2
Names
pre-T/NK cell associated protein (3Cl)
zygin 2
zygin II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042548.2NP_001036013.1  fasciculation and elongation protein zeta-2 isoform 2

    See identical proteins and their annotated locations for NP_001036013.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon, compared to variant 1, resulting in a longer protein isoform.
    Source sequence(s)
    AC007401, BC089390
    Consensus CDS
    CCDS46258.1
    UniProtKB/Swiss-Prot
    Q9UHY8
    Related
    ENSP00000368547.4, ENST00000379245.8
    Conserved Domains (1) summary
    pfam07763
    Location:51270
    FEZ; FEZ-like protein
  2. NM_005102.3NP_005093.2  fasciculation and elongation protein zeta-2 isoform 1

    See identical proteins and their annotated locations for NP_005093.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the more abundant transcript.
    Source sequence(s)
    AC007401, BC037566
    Consensus CDS
    CCDS46257.1
    UniProtKB/Swiss-Prot
    Q9UHY8
    Related
    ENSP00000385112.3, ENST00000405912.8
    Conserved Domains (1) summary
    pfam07763
    Location:51270
    FEZ; FEZ-like protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    36552239..36598190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712153.2XP_006712216.1  fasciculation and elongation protein zeta-2 isoform X1

    Related
    ENSP00000350685.4, ENST00000357996.4
    Conserved Domains (1) summary
    pfam07763
    Location:1169
    FEZ; FEZ-like protein

RNA

  1. XR_244972.3 RNA Sequence

    Related
    ENST00000451623.5
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