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ISG15 ISG15 ubiquitin like modifier [ Homo sapiens (human) ]

Gene ID: 9636, updated on 13-Mar-2020

Summary

Official Symbol
ISG15provided by HGNC
Official Full Name
ISG15 ubiquitin like modifierprovided by HGNC
Primary source
HGNC:HGNC:4053
See related
Ensembl:ENSG00000187608 MIM:147571
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G1P2; IP17; UCRP; IFI15; IMD38; hUCRP
Summary
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]
Expression
Broad expression in salivary gland (RPKM 43.3), spleen (RPKM 35.3) and 22 other tissues See more
Orthologs

Genomic context

See ISG15 in Genome Data Viewer
Location:
1p36.33
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (1013497..1014540)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (948847..949920)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene hes family bHLH transcription factor 4 Neighboring gene ribosomal protein L39 pseudogene 12 Neighboring gene agrin Neighboring gene uncharacterized LOC100288175 Neighboring gene uncharacterized LOC105378948 Neighboring gene translation initiation factor IF-2-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HERC5 restricts HIV-1 Gag particle production by a mechanism dependent on its E3 ligase activity. This restriction correlates with the conjugation of ISG15 to Gag by HERC5 PubMed
gag ISG15 inhibits budding of HIV-1 by disrupting the association between Vps4 and the Gag budding complex PubMed
Tat tat HIV-1 and the viral protein Tat modulate the expression of ISG15 ubiquitin-like modifier (ISG15) in immature dendritic cells and monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including ISG15, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
Vpr vpr HIV-1 Vpr upregulates the expression of ISG15 in human monocyte-derived dendritic cells PubMed
vpr HIV-1 Vpr upregulates the expression of ISG15 in human monocyte-derived macrophages PubMed
Vpu vpu The expression of ISG15 ubiquitin-like modifier is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ISG15-protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ISG15-protein conjugation IDA
Inferred from Direct Assay
more info
PubMed 
ISG15-protein conjugation IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interferon-gamma secretion IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-10 secretion IDA
Inferred from Direct Assay
more info
PubMed 
modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of type I interferon production TAS
Traceable Author Statement
more info
 
negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
NOT protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to type I interferon IDA
Inferred from Direct Assay
more info
PubMed 
translesion synthesis TAS
Traceable Author Statement
more info
 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-like protein ISG15
Names
interferon, alpha-inducible protein (clone IFI-15K)
interferon-induced 17-kDa/15-kDa protein
interferon-stimulated protein, 15 kDa
ubiquitin cross-reactive protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033033.2 RefSeqGene

    Range
    17360..18403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1231

mRNA and Protein(s)

  1. NM_005101.4NP_005092.1  ubiquitin-like protein ISG15

    See identical proteins and their annotated locations for NP_005092.1

    Status: REVIEWED

    Source sequence(s)
    AL645608, BC009507, BU161226, M13755
    Consensus CDS
    CCDS6.1
    UniProtKB/Swiss-Prot
    P05161
    Related
    ENSP00000496832.1, ENST00000649529.1
    Conserved Domains (3) summary
    cd01792
    Location:180
    ISG15_repeat1; ISG15 ubiquitin-like protein, first repeat of 2
    smart00213
    Location:82153
    UBQ; Ubiquitin homologues
    cl00155
    Location:84157
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    1013497..1014540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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