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NUP155 nucleoporin 155 [ Homo sapiens (human) ]

Gene ID: 9631, updated on 18-Aug-2020

Summary

Official Symbol
NUP155provided by HGNC
Official Full Name
nucleoporin 155provided by HGNC
Primary source
HGNC:HGNC:8063
See related
Ensembl:ENSG00000113569 MIM:606694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
N155; ATFB15
Summary
Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]
Expression
Broad expression in testis (RPKM 44.4), bone marrow (RPKM 5.5) and 19 other tissues See more
Orthologs

Genomic context

See NUP155 in Genome Data Viewer
Location:
5p13.2
Exon count:
36
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (37288137..37371106, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (37291735..37371228, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ciliogenesis and planar polarity effector 1 Neighboring gene uncharacterized LOC105374727 Neighboring gene RNA, 7SL, cytoplasmic 37, pseudogene Neighboring gene RNA, U7 small nuclear 75 pseudogene Neighboring gene WD repeat domain 70 Neighboring gene potassium channel tetramerization domain containing 9 pseudogene 5 Neighboring gene RNA, U6 small nuclear 1190, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nucleoporin 155kDa (NUP155) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of nucleoporin 155kDa (NUP155) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify 155kDa nucleoporin (NUP155), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify 155kDa nucleoporin (NUP155), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify 155kDa nucleoporin (NUP155), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify 155kDa nucleoporin (NUP155), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
capsid gag HIV-1 N74D CA mutant requires NUP155 for the nuclear import of HIV-1 PICs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0791

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
atrial cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
 
intracellular transport of virus TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
nuclear envelope organization IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sumoylation TAS
Traceable Author Statement
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of glycolytic process TAS
Traceable Author Statement
more info
 
tRNA export from nucleus TAS
Traceable Author Statement
more info
 
transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
host cell IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nuclear pore inner ring IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nuclear pore complex protein Nup155
Names
155 kDa nucleoporin
nucleoporin 155kD
nucleoporin 155kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034131.1 RefSeqGene

    Range
    5001..84494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278312.2NP_001265241.1  nuclear pore complex protein Nup155 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 3 which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AC025449, AI037962, AK297143, AK315028, BM478072, BQ435836, DC401967
    Consensus CDS
    CCDS64142.1
    UniProtKB/TrEMBL
    B4DLT2, E9PF10
    Related
    ENSP00000422019.1, ENST00000513532.1
    Conserved Domains (2) summary
    pfam03177
    Location:9441149
    Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal
    pfam08801
    Location:77507
    Nucleoporin_N; Nup133 N terminal like
  2. NM_004298.4NP_004289.1  nuclear pore complex protein Nup155 isoform 2

    See identical proteins and their annotated locations for NP_004289.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB018334, AC025449, AI037962, BC039257, BM478072, BQ435836, DA249538, DC401967
    Consensus CDS
    CCDS43310.1
    UniProtKB/Swiss-Prot
    O75694
    Related
    ENSP00000371265.2, ENST00000381843.6
    Conserved Domains (2) summary
    pfam03177
    Location:7731154
    Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal
    pfam08801
    Location:18448
    Nucleoporin_N; Nup133 N terminal like
  3. NM_153485.3NP_705618.1  nuclear pore complex protein Nup155 isoform 1

    See identical proteins and their annotated locations for NP_705618.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC025449, AI037962, BC039257, BM478072, BQ435836, DC401967
    Consensus CDS
    CCDS3921.1
    UniProtKB/Swiss-Prot
    O75694
    UniProtKB/TrEMBL
    A0A024R071
    Related
    ENSP00000231498.3, ENST00000231498.8
    Conserved Domains (2) summary
    pfam03177
    Location:8321213
    Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal
    pfam08801
    Location:77507
    Nucleoporin_N; Nup133 N terminal like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    37288137..37371106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514165.3XP_011512467.1  nuclear pore complex protein Nup155 isoform X1

    Conserved Domains (1) summary
    pfam08801
    Location:77507
    Nucleoporin_N; Nup133 N terminal like

RNA

  1. XR_001742368.2 RNA Sequence

  2. XR_001742369.2 RNA Sequence

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