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AATK apoptosis associated tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 9625, updated on 1-Aug-2020

Summary

Official Symbol
AATKprovided by HGNC
Official Full Name
apoptosis associated tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:21
See related
Ensembl:ENSG00000181409 MIM:605276
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LMR1; AATYK; LMTK1; p35BP; AATYK1; PPP1R77
Summary
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Expression
Biased expression in brain (RPKM 12.1), duodenum (RPKM 7.0) and 11 other tissues See more
Orthologs

Genomic context

See AATK in Genome Data Viewer
Location:
17q25.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81117295..81166221, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79084285..79139877, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene BAR/IMD domain containing adaptor protein 2 Neighboring gene Sharpr-MPRA regulatory region 8367 Neighboring gene uncharacterized LOC107987250 Neighboring gene Sharpr-MPRA regulatory region 11647 Neighboring gene microRNA 3065 Neighboring gene microRNA 657 Neighboring gene microRNA 338 Neighboring gene microRNA 1250 Neighboring gene parvalbumin like EF-hand containing Neighboring gene centrosomal protein 131 Neighboring gene uncharacterized LOC105371925 Neighboring gene TEPSIN adaptor related protein complex 4 accessory protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Messenger RNAs for three proteins AATK, SLC27A1, and CDKAL1 are preferentially secreted out in exosomes from HIV-1 Nef-expressing cells, and their targeting miRNAs (miR-32 and miR-93*) are retained in these cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0641

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase LMTK1
Names
CDK5-binding protein
brain apoptosis-associated tyrosine kinase
lemur tyrosine kinase 1
p35-binding protein
protein phosphatase 1, regulatory subunit 77
NP_001073864.2
NP_004911.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029981.1 RefSeqGene

    Range
    4852..53778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080395.3NP_001073864.2  serine/threonine-protein kinase LMTK1 isoform 1

    See identical proteins and their annotated locations for NP_001073864.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB014541, AC115099, AK131529, BI256809
    Consensus CDS
    CCDS45807.1
    UniProtKB/Swiss-Prot
    Q6ZMQ8
    Related
    ENSP00000324196.4, ENST00000326724.9
    Conserved Domains (2) summary
    smart00221
    Location:128395
    STYKc; Protein kinase; unclassified specificity
    cd05087
    Location:127397
    PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
  2. NM_004920.2NP_004911.2  serine/threonine-protein kinase LMTK1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AB014541, AC115099, AK131395, BI256809
    Consensus CDS
    CCDS58607.1
    UniProtKB/Swiss-Prot
    Q6ZMQ8
    UniProtKB/TrEMBL
    H7C175
    Related
    ENSP00000398796.1, ENST00000417379.6
    Conserved Domains (2) summary
    smart00221
    Location:25292
    STYKc; Protein kinase; unclassified specificity
    cd05087
    Location:24294
    PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81117295..81166221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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