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TCL1B TCL1 family AKT coactivator B [ Homo sapiens (human) ]

Gene ID: 9623, updated on 25-Nov-2025
Official Symbol
TCL1Bprovided by HGNC
Official Full Name
TCL1 family AKT coactivator Bprovided by HGNC
Primary source
HGNC:HGNC:11649
See related
Ensembl:ENSG00000213231 MIM:603769; AllianceGenome:HGNC:11649
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TML1; SYN-1
Summary
Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in testis (RPKM 1.5), lymph node (RPKM 1.2) and 6 other tissues See more
Orthologs
all
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See TCL1B in Genome Data Viewer
Location:
14q32.13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (95686426..95692628)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (89918003..89924209)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96152763..96158965)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370643 Neighboring gene Sharpr-MPRA regulatory region 452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8968 Neighboring gene uncharacterized LOC124903372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96131757-96132404 Neighboring gene T cell leukemia/lymphoma 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96133051-96133697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8972 Neighboring gene uncharacterized LOC124903373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8976 Neighboring gene TCL1 family AKT coactivator A

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus. Sugimoto J, et al. Cancer Res, 1999 May 15. PMID 10344735
  2. Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. Saitou M, et al. Oncogene, 2000 May 25. PMID 10851082
  3. The role of TCL1 in human T-cell leukemia. Pekarsky Y, et al. Oncogene, 2001 Sep 10. PMID 11607815
  4. Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. Pekarsky Y, et al. Proc Natl Acad Sci U S A, 1999 Mar 16. PMID 10077617, Free PMC Article
  5. Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications. Badve S, et al. Am J Pathol, 2010 May. PMID 20228224, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. subcellular localization of activated AKT is dependent on TCL1B expression in estrogen receptor- and progesterone receptor-expressing breast cancer
    Title: Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: TCL6

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
T-cell leukemia/lymphoma protein 1B
Names
T cell leukemia/lymphoma 1B
T-cell lymphoma/leukemia 1B
TCL1/ MTCP1-like 1
oncogene TCL-1B
syncytiotrophoblast-specific protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004918.4 → NP_004909.1  T-cell leukemia/lymphoma protein 1B

    See identical proteins and their annotated locations for NP_004909.1

    Status: VALIDATED

    Source sequence(s)
    AF137027, BC051000
    Consensus CDS
    CCDS32151.1
    UniProtKB/Swiss-Prot
    A6NEK7, O95988, Q6IAR7, Q9UBQ4
    Related
    ENSP00000343223.6, ENST00000340722.8
    Conserved Domains (1) summary
    pfam01840
    Location:1 → 124
    TCL1_MTCP1; TCL1/MTCP1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    95686426..95692628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    89918003..89924209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199206.2: Suppressed sequence

    Description
    NM_199206.2: This RefSeq was permanently suppressed because it retains intronic sequence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95988.1 GenPept UniProtKB/Swiss-Prot:O95988

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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