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RNF7 ring finger protein 7 [ Homo sapiens (human) ]

Gene ID: 9616, updated on 5-Jul-2020

Summary

Official Symbol
RNF7provided by HGNC
Official Full Name
ring finger protein 7provided by HGNC
Primary source
HGNC:HGNC:10070
See related
Ensembl:ENSG00000114125 MIM:603863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAG; ROC2; rbx2; CKBBP1
Summary
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Annotation information
Note: SAG (Gene ID: 6295) and RNF7 (Gene ID: 9616) share the SAG symbol/alias in common. SAG is a widely used alternative name for ring finger protein 7 (RNF7), which can be confused with the official symbol for SAG (S-antigen visual arrestin, GeneID 6295). [01 Jun 2018]
Expression
Ubiquitous expression in testis (RPKM 15.8), adrenal (RPKM 15.8) and 25 other tissues See more
Orthologs

Genomic context

See RNF7 in Genome Data Viewer
Location:
3q23
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (141738209..141747560)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141457051..141465645)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RAS p21 protein activator 2 Neighboring gene YWHAQ pseudogene 6 Neighboring gene long intergenic non-protein coding RNA 2618 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 3 Neighboring gene G protein-coupled receptor kinase 7 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4237

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif Rbx1 I44A and Rbx2 I52A mutants disrupt the level of HIV-1 Vif-mediated APOBEC3G degradation in cells PubMed
vif CUL5/RBX2/ELOB/ELOC/Vif/CBF-beta complex catalyzes polyubiquitin chain formation on A3G in the presence of ubiquitin E2 UBE2R1 (CDC34) or UBCH5b (UBE2D2) PubMed
vif UBE2F and RBX2 are required for activation of the polyubiquitin synthesis activity of Vif/CBF-beta/CUL5, leading to HIV-1 Vif-mediated degradation of A3G in cells PubMed
vif HIV-1 Vif can assemble into the Cul5-containing E3 ligase, the CUL5-RBX2-CBF-beta-ELOB-ELOC complex, in the presence of CBF-beta PubMed
vif HIV-1 Vif is identified to have a physical interaction with ring finger protein 7 (RNF7; RBX2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NEDD8 ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
NEDD8 transferase activity TAS
Traceable Author Statement
more info
 
copper ion binding TAS
Traceable Author Statement
more info
PubMed 
cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cullin family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein neddylation IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
response to redox state TAS
Traceable Author Statement
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Cul5-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Cul5-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
RING-box protein 2
Names
CKII beta-binding protein 1
regulator of cullins 2
sensitive to apoptosis gene protein
sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2
zinc RING finger protein SAG

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201370.1NP_001188299.1  RING-box protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001188299.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC112771, AW150174, BG742338, DB272382
    Consensus CDS
    CCDS56283.1
    UniProtKB/Swiss-Prot
    Q9UBF6
    Related
    ENSP00000419084.1, ENST00000480908.1
    Conserved Domains (1) summary
    cl17238
    Location:4790
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. NM_014245.5NP_055060.1  RING-box protein 2 isoform 1

    See identical proteins and their annotated locations for NP_055060.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC112771, AW150174, BG742338
    Consensus CDS
    CCDS3118.1
    UniProtKB/Swiss-Prot
    Q9UBF6
    Related
    ENSP00000273480.3, ENST00000273480.4
    Conserved Domains (1) summary
    cd16466
    Location:47106
    RING-H2_RBX2; RING finger, H2 subclass, found in RING-box protein 2 (RBX2) and similar proteins
  3. NM_183237.2NP_899060.1  RING-box protein 2 isoform 3

    See identical proteins and their annotated locations for NP_899060.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region compared to variant 1, which causes a frameshift. The resulting shorter isoform (3) has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC112771, AW150174, BG716023, BG742338
    Consensus CDS
    CCDS43158.1
    UniProtKB/Swiss-Prot
    Q9UBF6
    Related
    ENSP00000376725.3, ENST00000393000.3
    Conserved Domains (1) summary
    cl17238
    Location:2855
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. NR_037702.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon compared to variant 1, that causes a frameshift. The resulting transcript is a nonsense-mediated mRNA decay candidate and is not thought to be protein-coding.
    Source sequence(s)
    AC112771, AF312226, AW150174, BG742338
  2. NR_037703.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice junction and contains an alternate exon compared to variant 1, that causes a frameshift. The resulting transcript is a nonsense-mediated mRNA decay candidate and is not thought to be protein-coding.
    Source sequence(s)
    AC112771, AW150174, BG720797, BG742338

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    141738209..141747560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183063.1: Suppressed sequence

    Description
    NM_183063.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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