Format

Send to:

Choose Destination

NCOR2 nuclear receptor corepressor 2 [ Homo sapiens (human) ]

Gene ID: 9612, updated on 13-Mar-2020

Summary

Official Symbol
NCOR2provided by HGNC
Official Full Name
nuclear receptor corepressor 2provided by HGNC
Primary source
HGNC:HGNC:7673
See related
Ensembl:ENSG00000196498 MIM:600848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau
Summary
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Expression
Ubiquitous expression in fat (RPKM 14.9), lung (RPKM 14.3) and 25 other tissues See more
Orthologs

Genomic context

See NCOR2 in Genome Data Viewer
Location:
12q24.31
Exon count:
49
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (124324415..124567612, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (124808957..125052079, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ZNF664-RFLNA readthrough Neighboring gene zinc finger protein 664 Neighboring gene refilin A Neighboring gene microRNA 6880 Neighboring gene Sharpr-MPRA regulatory region 11802 Neighboring gene conserved acetylation island sequence 32 enhancer Neighboring gene uncharacterized LOC105370047 Neighboring gene Sharpr-MPRA regulatory region 12812 Neighboring gene uncharacterized LOC101927436

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
NHGRI GWA Catalog
Genome-wide association study identifies new disease loci for isolated clubfoot.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nuclear receptor corepressor 2 (NCOR2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25011

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucocorticoid receptor binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
retinoid X receptor binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional repressor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear receptor corepressor 2
Names
CTG repeat protein 26
T3 receptor-associating factor
silencing mediator for retinoid and thyroid hormone receptors
thyroid-, retinoic-acid-receptor-associated corepressor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_022928.2 RefSeqGene

    Range
    4853..248050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001077261.4NP_001070729.2  nuclear receptor corepressor 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple difference in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter than isoform 1.
    Source sequence(s)
    AC069261, AC073592, AC073916
    Consensus CDS
    CCDS41857.2
    UniProtKB/Swiss-Prot
    Q9Y618
    UniProtKB/TrEMBL
    C9JE98
    Related
    ENSP00000384202.1, ENST00000404621.5
    Conserved Domains (4) summary
    smart00717
    Location:613658
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:613656
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:142228
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:431474
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  2. NM_001206654.2NP_001193583.1  nuclear receptor corepressor 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple difference in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter than isoform 1.
    Source sequence(s)
    AC069261, AC073592, AC073916
    Consensus CDS
    CCDS55892.1
    UniProtKB/Swiss-Prot
    Q9Y618
    UniProtKB/TrEMBL
    C9J0Q5
    Related
    ENSP00000400281.2, ENST00000429285.6
    Conserved Domains (4) summary
    smart00717
    Location:613658
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:613656
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:142228
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:431474
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  3. NM_006312.6NP_006303.4  nuclear receptor corepressor 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC069261, AC073592, AC073916
    Consensus CDS
    CCDS41858.2
    UniProtKB/Swiss-Prot
    Q9Y618
    UniProtKB/TrEMBL
    C9JFD3
    Related
    ENSP00000384018.1, ENST00000405201.5
    Conserved Domains (6) summary
    pfam00249
    Location:614657
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:142228
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:432475
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cl25732
    Location:100458
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26464
    Location:9091192
    Atrophin-1; Atrophin-1 family
    cl27154
    Location:541649
    SWIRM; SWIRM domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    124324415..124567612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center