Format

Send to:

Choose Destination

RIN1 Ras and Rab interactor 1 [ Homo sapiens (human) ]

Gene ID: 9610, updated on 24-Nov-2020

Summary

Official Symbol
RIN1provided by HGNC
Official Full Name
Ras and Rab interactor 1provided by HGNC
Primary source
HGNC:HGNC:18749
See related
Ensembl:ENSG00000174791 MIM:605965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in skin (RPKM 7.4), stomach (RPKM 2.6) and 21 other tissues See more
Orthologs

Genomic context

See RIN1 in Genome Data Viewer
Location:
11q13.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (66330241..66336774, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66099535..66104000, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 151A Neighboring gene CD248 molecule Neighboring gene BRMS1 transcriptional repressor and anoikis regulator Neighboring gene beta-1,4-glucuronyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
associative learning IEA
Inferred from Electronic Annotation
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras and Rab interactor 1
Names
ras inhibitor 1
ras inhibitor JC99
ras inhibitor RIN1
ras interaction/interference protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363559.2NP_001350488.1  ras and Rab interactor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001107
    Related
    ENST00000526246.5
    Conserved Domains (3) summary
    smart00167
    Location:461579
    VPS9; Domain present in VPS9
    cl00155
    Location:599676
    UBQ; Ubiquitin-like proteins
    cl15255
    Location:30130
    SH2; Src homology 2 (SH2) domain
  2. NM_001363560.2NP_001350489.1  ras and Rab interactor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001107
    Conserved Domains (3) summary
    smart00167
    Location:429545
    VPS9; Domain present in VPS9
    cd10393
    Location:58158
    SH2_RIN1; Src homology 2 (SH2) domain found in Ras and Rab interactor 1 (RIN1)-like proteins
    cl00155
    Location:565642
    UBQ; Ubiquitin-like proteins
  3. NM_004292.3NP_004283.2  ras and Rab interactor 1 isoform 1

    See identical proteins and their annotated locations for NP_004283.2

    Status: VALIDATED

    Source sequence(s)
    AP001107, BC014417, BG163919, BQ956294, L36463
    Consensus CDS
    CCDS31614.1
    UniProtKB/Swiss-Prot
    Q13671
    UniProtKB/TrEMBL
    A0A0S2Z4U0
    Related
    ENSP00000310406.4, ENST00000311320.9
    Conserved Domains (3) summary
    smart00167
    Location:489607
    VPS9; Domain present in VPS9
    cl00155
    Location:627704
    UBQ; Ubiquitin-like proteins
    cl15255
    Location:58158
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    66330241..66336774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018587.1XP_016874076.1  ras and Rab interactor 1 isoform X2

    Related
    ENSP00000432798.1, ENST00000530056.1
Support Center