CD44 CD44 molecule (Indian blood group) [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD44provided by HGNC
Official Full Name: CD44 molecule (Indian blood group)provided by HGNC
Primary source: HGNC:HGNC:1681
See related: Ensembl:ENSG00000026508 MIM:107269
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III
Summary: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
Expression: Broad expression in skin (RPKM 96.7), appendix (RPKM 60.6) and 19 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 11p13

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	11	NC_000011.10 (35138870..35232402)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (35160417..35253949)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

BMP-2 could enhance migration and proliferation of hypoxia-induced VSMCs via the Actin/CD44/MMP-2 molecular pathway.
Title: BMP-2 enhances the migration and proliferation of hypoxia-induced VSMCs via actin cytoskeleton, CD44 and matrix metalloproteinase linkage.
High CD44v9 expression in pre-neoadjuvant chemotherapy (NAC) samples was associated with poor prognosis in triple-negative breast cancer patients treated with NAC, especially for those in whom pathological complete response was not achieved.
Title: CD44v9 as a poor prognostic factor of triple-negative breast cancer treated with neoadjuvant chemotherapy.
Data show that IgD interacts with basophils through the CD44-binding protein galectin-9.
Title: Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44.
The study identified and validated CD44, a transmembrane adhesion receptor for hyaluronan, as direct and functional target of miR-492. The study identified miR-492 and its target CD44 as regulators of a number of biological features important for malignancy and metastasis.
Title: MiR-492 regulates metastatic properties of hepatoblastoma via CD44.
USP22-NLs-CD44 was demonstrated to be able to effectively deliver USP22 siRNA to CD44(+) gastric cancer stem cells, achieving superior therapeutic effects against CD44(+) gastric cancer stem cells than nontargeted nanoliposomes. USP22-NLs-CD44 may provide a novel approach to eradicate gastric cancer stem cells in the near future
Title: Targeted eradication of gastric cancer stem cells by CD44 targeting USP22 small interfering RNA-loaded nanoliposomes.
Basement membrane protein ladinin-1 and the MIF-CD44-beta1 integrin signaling axis are implicated in laryngeal cancer metastasis
Title: Basement membrane protein ladinin-1 and the MIF-CD44-β1 integrin signaling axis are implicated in laryngeal cancer metastasis.
anti-CD44v6 treatment reduced leukemic cell proliferation in vitro in human and mouse, confirming the general nature of the findings. In summary, we propose a CD44-NF-kappaB-CD44v6 circuit in CLL, allowing tumor cells to gain HA binding capacity and supporting their proliferation.
Title: Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia.
A clear correlation between the presence of CD44v6/ErbB1 complexes in breast cancer patients and lymph node metastases.
Title: Differential recruitment of CD44 isoforms by ErbB ligands reveals an involvement of CD44 in breast cancer.
expression of CD44 and Lgr5 is related to the malignant biological behavior of colorectal cancer, and they are important factors in promoting local and distant metastases
Title: [Expression of stem cell markers CD44 and Lgr5 in colorectal cancer and its relationship with lymph node and liver metastasis].
It is a putative cancer stem cell biomarker and CD44 immunoexpression was a significant predictor of lymph node metastasis.
Title: CD44 and ALDH1 immunoexpression as prognostic indicators of invasion and metastasis in oral squamous cell carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (985)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
INDIAN BLOOD GROUP SYSTEM MedGen: C1292298 OMIM: 609027 GeneReviews: Not available	not available

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD44	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	CD44, which localizes exclusively to the plasma membrane and is absent from endosomes, is detected at HIV-1 Env budding sites and efficiently incorporated into HIV-1 particles	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 ectodomain fragment (amino acids 550-639) induces CD44 and beta-actin redistribution to the membrane lipid rafts on the human brain micro vascular endothelial cells	PubMed
Pr55(Gag)	gag	Basic sequences in the cytoplasmic domains of PSGL-1, CD43, and CD44 are required for efficient association with HIV-1 Gag in HeLa cells	PubMed
	gag	HIV-1 Gag multimers associate with a specific subset of uropod-directed microdomains (UDMs) containing PSGL-1, CD43, and CD44	PubMed
Tat	tat	HIV-1 Tat101 downregulates the expression of CD44 in Jurkat cells	PubMed
Vif	vif	HIV-1 Vif upregulates the expression of CD44 (Indian blood group) in Vif-expression T cells	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of CD44 expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed
	vpr	HIV-1 Vpr potentiates the suppression of CD44 by glucocorticoids via the glucocorticoid receptor pathway	PubMed
matrix	gag	HIV-1 matrix protein co-localizes with syndecan-2, syndecan-4, and CD44v3 on activated CD4+ T cells to modulate TNF-alpha and IL2 production	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
ECM-receptor interaction, organism-specific biosystem (from KEGG)
ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
ECM-receptor interaction, conserved biosystem (from KEGG)
ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Epstein-Barr virus infection, conserved biosystem (from KEGG)
Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Extracellular matrix organization, organism-specific biosystem (from REACTOME)
Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Hematopoietic cell lineage, conserved biosystem (from KEGG)
Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
Hepatitis C and Hepatocellular Carcinoma, organism-specific biosystem (from WikiPathways)
Hepatitis C and Hepatocellular Carcinoma, organism-specific biosystemPathway model based on hub miRNAs and their putative targets from network analysis. - From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carc...
Hyaluronan metabolism, organism-specific biosystem (from REACTOME)
Hyaluronan metabolism, organism-specific biosystemHyaluronan (hyaluronic acid, hyaluronate or HA) is an anionic glycosaminoglycan (GAG) distributed widely throughout connective, epithelial, and neural tissues and most abundant in the extracellular m...
Hyaluronan uptake and degradation, organism-specific biosystem (from REACTOME)
Hyaluronan uptake and degradation, organism-specific biosystemHyaluronan (HA) turnover can occur locally at the tissue of origin, where it is taken up by cells to be degraded, or released into the lymphatic and vascular systems, where it can be eliminated by th...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
Interferon Signaling, organism-specific biosystem (from REACTOME)
Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
Interferon gamma signaling, organism-specific biosystem (from REACTOME)
Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
MicroRNAs in cancer, organism-specific biosystem (from KEGG)
MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
MicroRNAs in cancer, conserved biosystem (from KEGG)
MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
Neutrophil degranulation, organism-specific biosystem (from REACTOME)
Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
Osteopontin-mediated events, organism-specific biosystem
Osteopontin-mediated events
Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem (from Pathway Interaction Database)
Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem
Paxillin-independent events mediated by a4b1 and a4b7
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
Shigellosis, organism-specific biosystem (from KEGG)
Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-H03494 (e-PCR)
- UniSTS:34564

STS-N23307 (e-PCR)
- UniSTS:69894

Cd44 (e-PCR), detects polymorphism
- UniSTS:525578

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

GDB:185470 (e-PCR)
- UniSTS:155448

RH35975 (e-PCR)
- UniSTS:77632

G15910 (e-PCR)
- UniSTS:42305

D11S4589 (e-PCR)
- UniSTS:18756

RH69895 (e-PCR)
- UniSTS:24909

CD44_1447 (e-PCR)
- UniSTS:277075

PMC111028P1 (e-PCR)
- UniSTS:270201

G62926 (e-PCR)
- UniSTS:139901

D11S4430 (e-PCR)
- UniSTS:9858

PMC303366P9 (e-PCR)
- UniSTS:272516

D11S3129 (e-PCR)
- UniSTS:152220

SHGC-58498 (e-PCR)
- UniSTS:94370

RH36176 (e-PCR)
- UniSTS:21925

AFM283wh9 (e-PCR)
- UniSTS:80571

RH68898 (e-PCR)
- UniSTS:3025

G62000 (e-PCR)
- UniSTS:139219

RH103158 (e-PCR)
- UniSTS:97492

GDB:196637 (e-PCR)
- UniSTS:155877

CD44 (e-PCR), detects polymorphism
- UniSTS:47355

Homology

Homologs of the CD44 gene: The CD44 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 239 organisms have orthologs with human gene CD44
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
collagen binding	NAS Non-traceable Author Statement more info	PubMed
contributes_to cytokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
hyaluronic acid binding	IDA Inferred from Direct Assay more info	PubMed
hyaluronic acid binding	NAS Non-traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
T cell activation	IDA Inferred from Direct Assay more info	PubMed
cartilage development	IEP Inferred from Expression Pattern more info	PubMed
cell adhesion	IDA Inferred from Direct Assay more info	PubMed
cell migration	IDA Inferred from Direct Assay more info	PubMed
cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
cell-matrix adhesion	NAS Non-traceable Author Statement more info	PubMed
cellular response to fibroblast growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
extracellular matrix disassembly	TAS Traceable Author Statement more info
extracellular matrix organization	TAS Traceable Author Statement more info
hyaluronan catabolic process	IDA Inferred from Direct Assay more info	PubMed
hyaluronan catabolic process	TAS Traceable Author Statement more info
interferon-gamma-mediated signaling pathway	TAS Traceable Author Statement more info
leukocyte migration	TAS Traceable Author Statement more info
monocyte aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
neutrophil degranulation	TAS Traceable Author Statement more info
positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of monocyte aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of lamellipodium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
wound healing, spreading of cells	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info
apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
cell projection	IDA Inferred from Direct Assay more info	PubMed
cell surface	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info
extracellular exosome	HDA more info	PubMed
focal adhesion	HDA more info	PubMed
integral component of plasma membrane	NAS Non-traceable Author Statement more info	PubMed
lamellipodium membrane	IDA Inferred from Direct Assay more info	PubMed
macrophage migration inhibitory factor receptor complex	IDA Inferred from Direct Assay more info	PubMed
microvillus	ISS Inferred from Sequence or Structural Similarity more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: CD44 antigen

Names: GP90 lymphocyte homing/adhesion receptor; Hermes antigen; Indian blood group antigen; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; epican; extracellular matrix receptor III; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; homing function and Indian blood group system; hyaluronate receptor; phagocytic glycoprotein 1; soluble CD44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008937.1 RefSeqGene

Range

5001..98533

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000610.3 → NP_000601.3 CD44 antigen isoform 1 precursor

See identical proteins and their annotated locations for NP_000601.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. It encodes the longest isoform (1).

Source sequence(s)

AK127622, AL832642, AY101192, BC004372, BF828674, BF872530, CD721908

Consensus CDS

CCDS7897.1

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000398632.2, ENST00000428726.7

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001001389.1 → NP_001001389.1 CD44 antigen isoform 2 precursor

See identical proteins and their annotated locations for NP_001001389.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.

Source sequence(s)

AK127622, AL832642, AY101192, BC004372, BF828674, CD721908

Consensus CDS

CCDS31455.1

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000389830.2, ENST00000415148.6

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001001390.1 → NP_001001390.1 CD44 antigen isoform 3 precursor

See identical proteins and their annotated locations for NP_001001390.1

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as CD44R, lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AK127622, AL832642, AY101192, BG946113, CD721908

Consensus CDS

CCDS31456.1

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000392331.2, ENST00000433892.6

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001001391.1 → NP_001001391.1 CD44 antigen isoform 4 precursor

See identical proteins and their annotated locations for NP_001001391.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (4) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AK127622, AL832642, AY101192, CD721908

Consensus CDS

CCDS31457.1

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000263398.6, ENST00000263398.10

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001001392.1 → NP_001001392.1 CD44 antigen isoform 5 precursor

See identical proteins and their annotated locations for NP_001001392.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks multiple coding-exons compared to variant 1. The translation frame is changed. The resulting isoform (5), also known as CD44 isoform RC, has a distinct and shorter C-terminus, as compared to isoform 1.

Source sequence(s)

AK127622, AL832642, AY101192, CD721908, W47313

Consensus CDS

CCDS31458.1

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000278386.6, ENST00000278386.10

Conserved Domains (1) summary

cl02612
Location:26 → 78

Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...
NM_001202555.1 → NP_001189484.1 CD44 antigen isoform 6 precursor

See identical proteins and their annotated locations for NP_001189484.1

Status: REVIEWED

Description

Transcript Variant: This variant (6), also known as CD44R2, lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (6) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AL133330, AL832642, EF581837

Consensus CDS

CCDS55754.1

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000404447.2, ENST00000434472.6

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001202556.1 → NP_001189485.1 CD44 antigen isoform 7 precursor

See identical proteins and their annotated locations for NP_001189485.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (7) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AL133330, AL832642, FJ216964

Consensus CDS

CCDS55755.1

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000309732.6, ENST00000352818.8

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001202557.1 → NP_001189486.1 CD44 antigen isoform 8 precursor

See identical proteins and their annotated locations for NP_001189486.1

Status: REVIEWED

Description

Transcript Variant: This variant (8), also known as Hermes, lacks multiple in-frame coding-exons and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (8) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AL133330, AL832642, M25078

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000398099.2, ENST00000442151.6

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p12 Primary Assembly

Range

35138870..35232402

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005253231.3 → XP_005253288.1 CD44 antigen isoform X1

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_011520482.2 → XP_011518784.1 CD44 antigen isoform X6

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_005253232.3 → XP_005253289.1 CD44 antigen isoform X2

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_017018583.2 → XP_016874072.1 CD44 antigen isoform X5
XM_006718388.2 → XP_006718451.1 CD44 antigen isoform X3

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_005253239.3 → XP_005253296.1 CD44 antigen isoform X11

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_017018584.2 → XP_016874073.1 CD44 antigen isoform X14
XM_005253235.3 → XP_005253292.1 CD44 antigen isoform X4

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_005253240.3 → XP_005253297.1 CD44 antigen isoform X13

See identical proteins and their annotated locations for XP_005253297.1

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_017018585.2 → XP_016874074.1 CD44 antigen isoform X17
XM_011520483.2 → XP_011518785.1 CD44 antigen isoform X7

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_011520484.2 → XP_011518786.1 CD44 antigen isoform X8

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_011520485.2 → XP_011518787.1 CD44 antigen isoform X9

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_005253238.3 → XP_005253295.1 CD44 antigen isoform X10

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_011520486.2 → XP_011518788.1 CD44 antigen isoform X12

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_011520488.2 → XP_011518790.1 CD44 antigen isoform X16

See identical proteins and their annotated locations for XP_011518790.1

UniProtKB/Swiss-Prot

P16070

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_011520487.3 → XP_011518789.1 CD44 antigen isoform X15

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_011520489.3 → XP_011518791.1 CD44 antigen isoform X18

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_006718390.4 → XP_006718453.1 CD44 antigen isoform X19

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...