CD44 CD44 molecule (IN blood group) [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD44provided by HGNC
Official Full Name: CD44 molecule (IN blood group)provided by HGNC
Primary source: HGNC:HGNC:1681
See related: Ensembl:ENSG00000026508 MIM:107269; AllianceGenome:HGNC:1681
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; H-CAM; HCELL; ECM-III; HUTCH-1; HUTCH-I; ECMR-III; Hermes-1
Summary: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
Expression: Broad expression in skin (RPKM 96.7), appendix (RPKM 60.6) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p13

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (35139171..35232402)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (35277234..35370499)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (35160718..35253949)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic Signatures: CD44 Single-Nucleotide Polymorphisms Affect Cell Surface Expression and Elevate Risk in Head and Neck Squamous Cell Carcinoma.
Title: Genetic Signatures: CD44 Single-Nucleotide Polymorphisms Affect Cell Surface Expression and Elevate Risk in Head and Neck Squamous Cell Carcinoma.
CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy.
Title: CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy.
Impact of CD44 genetic variants on clinicopathological characteristics of uterine cervical cancer patients.
Title: Impact of CD44 genetic variants on clinicopathological characteristics of uterine cervical cancer patients.
Co-expression of CD44v6 and MMP2 predicts lung metastasis and unfavorable prognosis in osteosarcoma.
Title: Co-expression of CD44v6 and MMP2 predicts lung metastasis and unfavorable prognosis in osteosarcoma.
Secreted factors from M1 macrophages drive prostate cancer stem cell plasticity by upregulating NANOG, SOX2, and CD44 through NFkappaB-signaling.
Title: Secreted factors from M1 macrophages drive prostate cancer stem cell plasticity by upregulating NANOG, SOX2, and CD44 through NFκB-signaling.
RNA-binding protein LSM7 facilitates breast cancer metastasis through mediating alternative splicing of CD44.
Title: RNA-binding protein LSM7 facilitates breast cancer metastasis through mediating alternative splicing of CD44.
CALCR exacerbates renal cell carcinoma progression via stabilizing CD44.
Title: CALCR exacerbates renal cell carcinoma progression via stabilizing CD44.
Deletion of CD44 promotes adipogenesis by regulating PPARgamma and cell cycle-related pathways.
Title: Deletion of CD44 promotes adipogenesis by regulating PPARγ and cell cycle-related pathways.
Associations of stem cell markers CD44, CD24 and ALDH1A1 with mammographic breast density in women with benign breast biopsies.
Title: Associations of stem cell markers CD44, CD24 and ALDH1A1 with mammographic breast density in women with benign breast biopsies.
Single-cell transcriptome sequencing reveals SPP1-CD44-mediated macrophage-tumor cell interactions drive chemoresistance in TNBC.
Title: Single-cell transcriptome sequencing reveals SPP1-CD44-mediated macrophage-tumor cell interactions drive chemoresistance in TNBC.

Submit: New GeneRIF Correction See all GeneRIFs (1273)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Blood group, Indian system MedGen: C1292298 OMIM: 609027 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD44	PubMed

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	CD44, which localizes exclusively to the plasma membrane and is absent from endosomes, is detected at HIV-1 Env budding sites and efficiently incorporated into HIV-1 particles	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 ectodomain fragment (amino acids 550-639) induces CD44 and beta-actin redistribution to the membrane lipid rafts on the human brain micro vascular endothelial cells	PubMed
Pr55(Gag)	gag	Basic sequences in the cytoplasmic domains of PSGL-1, CD43, and CD44 are required for efficient association with HIV-1 Gag in HeLa cells	PubMed
	gag	HIV-1 Gag multimers associate with a specific subset of uropod-directed microdomains (UDMs) containing PSGL-1, CD43, and CD44	PubMed
Tat	tat	HIV-1 Tat101 downregulates the expression of CD44 in Jurkat cells	PubMed
Vif	vif	HIV-1 Vif upregulates the expression of CD44 (Indian blood group) in Vif-expression T cells	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of CD44 expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed
	vpr	HIV-1 Vpr potentiates the suppression of CD44 by glucocorticoids via the glucocorticoid receptor pathway	PubMed
matrix	gag	HIV-1 matrix protein co-localizes with syndecan-2, syndecan-4, and CD44v3 on activated CD4+ T cells to modulate TNF-alpha and IL2 production	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-H03494 (e-PCR)
- UniSTS:34564

STS-N23307 (e-PCR)
- UniSTS:69894

Cd44 (e-PCR), detects polymorphism
- UniSTS:525578

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

GDB:185470 (e-PCR)
- UniSTS:155448

RH35975 (e-PCR)
- UniSTS:77632

G15910 (e-PCR)
- UniSTS:42305

D11S4589 (e-PCR)
- UniSTS:18756

RH69895 (e-PCR)
- UniSTS:24909

CD44_1447 (e-PCR)
- UniSTS:277075

PMC111028P1 (e-PCR)
- UniSTS:270201

G62926 (e-PCR)
- UniSTS:139901

D11S4430 (e-PCR)
- UniSTS:9858

PMC303366P9 (e-PCR)
- UniSTS:272516

D11S3129 (e-PCR)
- UniSTS:152220

SHGC-58498 (e-PCR)
- UniSTS:94370

RH36176 (e-PCR)
- UniSTS:21925

AFM283wh9 (e-PCR)
- UniSTS:80571

RH68898 (e-PCR)
- UniSTS:3025

G62000 (e-PCR)
- UniSTS:139219

RH103158 (e-PCR)
- UniSTS:97492

GDB:196637 (e-PCR)
- UniSTS:155877

CD44 (e-PCR), detects polymorphism
- UniSTS:47355

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables collagen binding	NAS Non-traceable Author Statement more info	PubMed
contributes_to cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to cytokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables hyaluronic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-matrix adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hyaluronan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in monocyte aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monocyte aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of lamellipodium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in system development	IEA Inferred from Electronic Annotation more info
involved_in wound healing, spreading of cells	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	HDA more info	PubMed
located_in lamellipodium membrane	IDA Inferred from Direct Assay more info	PubMed
part_of macrophage migration inhibitory factor receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of macrophage migration inhibitory factor receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: CD44 antigen

Names: CD44 molecule (Indian blood group); GP90 lymphocyte homing/adhesion receptor; Hermes antigen; In(Lu) related-p80; Indian blood group antigen; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; epican; extracellular matrix receptor III; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; homing cell adhesion molecule; homing function and Indian blood group system; hyaluronate receptor; phagocyte glycoprotein 1; phagocytic glycoprotein 1; soluble CD44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008937.1 RefSeqGene

Range

5302..98533

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_815

mRNA and Protein(s)

NM_000610.4 → NP_000601.3 CD44 antigen isoform 1 precursor

See identical proteins and their annotated locations for NP_000601.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. It encodes the longest isoform (1).

Source sequence(s)

AK127622, AL832642, AY101192, BC004372, BF828674, BF872530, CD721908

Consensus CDS

CCDS7897.1

UniProtKB/Swiss-Prot

A5YRN9, B6EAT9, D3DR12, D3DR13, O95370, P16070, P22511, Q04858, Q13419, Q13957, Q13958, Q13959, Q13960, Q13961, Q13967, Q13968, Q13980, Q15861, Q16064, Q16065, Q16066, Q16208, Q16522, Q86T72, Q86Z27, Q8N694, Q92493, Q96J24, Q9H5A5, Q9UC28, Q9UC29, Q9UC30, Q9UCB0, Q9UJ36

Related

ENSP00000398632.2, ENST00000428726.8

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001001389.2 → NP_001001389.1 CD44 antigen isoform 2 precursor

See identical proteins and their annotated locations for NP_001001389.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.

Source sequence(s)

AK127622, AL832642, AY101192, BC004372, BF828674, CD721908

Consensus CDS

CCDS31455.1

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000389830.2, ENST00000415148.6

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001001390.2 → NP_001001390.1 CD44 antigen isoform 3 precursor

See identical proteins and their annotated locations for NP_001001390.1

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as CD44R, lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AK127622, AL832642, AY101192, BG946113, CD721908

Consensus CDS

CCDS31456.1

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000392331.2, ENST00000433892.6

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001001391.2 → NP_001001391.1 CD44 antigen isoform 4 precursor

See identical proteins and their annotated locations for NP_001001391.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (4) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AK127622, AL832642, AY101192, CD721908

Consensus CDS

CCDS31457.1

UniProtKB/TrEMBL

A0A385KNS5, A8K309

Related

ENSP00000263398.6, ENST00000263398.11

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001001392.2 → NP_001001392.1 CD44 antigen isoform 5 precursor

See identical proteins and their annotated locations for NP_001001392.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks multiple coding-exons compared to variant 1. The translation frame is changed. The resulting isoform (5), also known as CD44 isoform RC, has a distinct and shorter C-terminus, as compared to isoform 1.

Source sequence(s)

AK127622, AL832642, AY101192, CD721908, W47313

Consensus CDS

CCDS31458.1

UniProtKB/Swiss-Prot

P16070

Related

ENSP00000278386.6, ENST00000278386.10

Conserved Domains (1) summary

cl02612
Location:26 → 78

Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...
NM_001202555.2 → NP_001189484.1 CD44 antigen isoform 6 precursor

See identical proteins and their annotated locations for NP_001189484.1

Status: REVIEWED

Description

Transcript Variant: This variant (6), also known as CD44R2, lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (6) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AL133330, AL832642, EF581837

Consensus CDS

CCDS55754.1

UniProtKB/TrEMBL

A0A385KNS5, A8K309

Related

ENSP00000404447.2, ENST00000434472.6

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001202556.2 → NP_001189485.1 CD44 antigen isoform 7 precursor

See identical proteins and their annotated locations for NP_001189485.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (7) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AL133330, AL832642, FJ216964

Consensus CDS

CCDS55755.1

UniProtKB/TrEMBL

A0A385KNS5, A8K309

Related

ENSP00000309732.6, ENST00000352818.8

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001202557.2 → NP_001189486.1 CD44 antigen isoform 8 precursor

See identical proteins and their annotated locations for NP_001189486.1

Status: REVIEWED

Description

Transcript Variant: This variant (8), also known as Hermes, lacks multiple in-frame coding-exons and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (8) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AL133330, AL832642, M25078

UniProtKB/TrEMBL

H0Y5E4

Related

ENSP00000398099.2, ENST00000442151.6

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001440324.1 → NP_001427253.1 CD44 antigen isoform 9 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000574072.1, ENST00000904013.1
NM_001440325.1 → NP_001427254.1 CD44 antigen isoform 10 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000639412.1, ENST00000969353.1
NM_001440326.1 → NP_001427255.1 CD44 antigen isoform 11 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215
NM_001440327.1 → NP_001427256.1 CD44 antigen isoform 12 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000574077.1, ENST00000904018.1
NM_001440328.1 → NP_001427257.1 CD44 antigen isoform 13 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000574081.1, ENST00000904022.1
NM_001440329.1 → NP_001427258.1 CD44 antigen isoform 14 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215
NM_001440330.1 → NP_001427259.1 CD44 antigen isoform 15 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000639419.1, ENST00000969360.1
NM_001440331.1 → NP_001427260.1 CD44 antigen isoform 16 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215
NM_001440332.1 → NP_001427261.1 CD44 antigen isoform 17 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000639414.1, ENST00000969355.1
NM_001440333.1 → NP_001427262.1 CD44 antigen isoform 18 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215
NM_001440334.1 → NP_001427263.1 CD44 antigen isoform 19 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215
NM_001440335.1 → NP_001427264.1 CD44 antigen isoform 20 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000639404.1, ENST00000969345.1
NM_001440336.1 → NP_001427265.1 CD44 antigen isoform 21 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215
NM_001440337.1 → NP_001427266.1 CD44 antigen isoform 22 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215
NM_001440338.1 → NP_001427267.1 CD44 antigen isoform 23 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000574082.1, ENST00000904023.1
NM_001440339.1 → NP_001427268.1 CD44 antigen isoform 24 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215
NM_001440340.1 → NP_001427269.1 CD44 antigen isoform 25 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000639407.1, ENST00000969348.1
NM_001440341.1 → NP_001427270.1 CD44 antigen isoform 26 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000639392.1, ENST00000969333.1
NM_001440342.1 → NP_001427271.1 CD44 antigen isoform 27 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000574071.1, ENST00000904012.1
NM_001440343.1 → NP_001427272.1 CD44 antigen isoform 28 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000639426.1, ENST00000969367.1
NM_001440344.1 → NP_001427273.1 CD44 antigen isoform 29 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000574076.1, ENST00000904017.1
NM_001440345.1 → NP_001427274.1 CD44 antigen isoform 30 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000574073.1, ENST00000904014.1
NM_001440346.1 → NP_001427275.1 CD44 antigen isoform 31 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000639399.1, ENST00000969340.1
NM_001440347.1 → NP_001427276.1 CD44 antigen isoform 32 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000639397.1, ENST00000969338.1
NM_001440348.1 → NP_001427277.1 CD44 antigen isoform 33 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215
NM_001440349.1 → NP_001427278.1 CD44 antigen isoform 34 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

Related

ENSP00000605570.1, ENST00000935511.1
NM_001440350.1 → NP_001427279.1 CD44 antigen isoform 35 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

UniProtKB/TrEMBL

A0A385KNS5, A8K309

Related

ENSP00000639403.1, ENST00000969344.1
NM_001440351.1 → NP_001427280.1 CD44 antigen isoform 36 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215
NM_001440352.1 → NP_001427281.1 CD44 antigen isoform 37 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215
NM_001440353.1 → NP_001427282.1 CD44 antigen isoform 38 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215
NM_001440354.1 → NP_001427283.1 CD44 antigen isoform 39 precursor

Status: REVIEWED

Source sequence(s)

AL133330, AL356215

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

35139171..35232402

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011520482.3 → XP_011518784.1 CD44 antigen isoform X7

Related

ENSP00000639435.1, ENST00000969376.1

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_005253232.4 → XP_005253289.1 CD44 antigen isoform X2

Related

ENSP00000639405.1, ENST00000969346.1

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_017018583.3 → XP_016874072.1 CD44 antigen isoform X6
XM_011520485.3 → XP_011518787.1 CD44 antigen isoform X11

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_011520487.4 → XP_011518789.1 CD44 antigen isoform X22

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...