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CREB5 cAMP responsive element binding protein 5 [ Homo sapiens (human) ]

Gene ID: 9586, updated on 6-Sep-2021

Summary

Official Symbol
CREB5provided by HGNC
Official Full Name
cAMP responsive element binding protein 5provided by HGNC
Primary source
HGNC:HGNC:16844
See related
Ensembl:ENSG00000146592 MIM:618262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CREB-5; CREBPA; CRE-BPA
Summary
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 3.3), brain (RPKM 3.0) and 22 other tissues See more
Orthologs
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Genomic context

See CREB5 in Genome Data Viewer
Location:
7p15.1-p14.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (28299321..28825894)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (28338940..28865511)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene JAZF zinc finger 1 Neighboring gene JAZF1 antisense RNA 1 Neighboring gene peptidylprolyl isomerase A pseudogene 80 Neighboring gene VISTA enhancer hs1604 Neighboring gene ribosomal protein S2 pseudogene 30 Neighboring gene Sharpr-MPRA regulatory region 6215 Neighboring gene TLR4 interactor with leucine rich repeats

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
GeneReviews: Not available
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
GeneReviews: Not available
Genome-wide association study of co-occurring anxiety in major depression.
GeneReviews: Not available
Genome-wide meta-analysis for severe diabetic retinopathy.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
cyclic AMP-responsive element-binding protein 5
Names
cAMP response element-binding protein CRE-BPa
cAMP-response element-binding protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011666.3NP_001011666.1  cyclic AMP-responsive element-binding protein 5 isoform delta

    See identical proteins and their annotated locations for NP_001011666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks several 5' exons and uses an alternate 5' terminal exon which results in the use of a downstream start codon, compared to variant 1. It encodes isoform delta which is shorter and contains a distinct N-terminus compared to isoform alpha.
    Source sequence(s)
    AC005013, BC059400, BQ130001
    Consensus CDS
    CCDS43563.1
    UniProtKB/Swiss-Prot
    Q02930
    Related
    ENSP00000379592.2, ENST00000396298.6
    Conserved Domains (1) summary
    cd14687
    Location:238297
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  2. NM_004904.4NP_004895.2  cyclic AMP-responsive element-binding protein 5 isoform beta

    See identical proteins and their annotated locations for NP_004895.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a 5' exon and uses an alternate 5' terminal exon which results in the use of a downstream in-frame start codon, compared to variant 1. It encodes isoform beta which has a shorter N-terminus compared to isoform alpha.
    Source sequence(s)
    AB451409, AC005013, AC006980, BQ130001, L05911
    Consensus CDS
    CCDS5418.1
    UniProtKB/Swiss-Prot
    Q02930
    Related
    ENSP00000379594.2, ENST00000396300.6
    Conserved Domains (1) summary
    cd14687
    Location:370429
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  3. NM_182898.4NP_878901.2  cyclic AMP-responsive element-binding protein 5 isoform alpha

    See identical proteins and their annotated locations for NP_878901.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (alpha).
    Source sequence(s)
    AB451409, AC005013, AC006367, BQ130001, L05515
    Consensus CDS
    CCDS5417.1
    UniProtKB/Swiss-Prot
    Q02930
    Related
    ENSP00000350359.2, ENST00000357727.7
    Conserved Domains (1) summary
    cd14687
    Location:377436
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  4. NM_182899.5NP_878902.2  cyclic AMP-responsive element-binding protein 5 isoform gamma

    See identical proteins and their annotated locations for NP_878902.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two 5' exons and uses an alternate 5' terminal exon which results in the use of a downstream in-frame start codon, compared to variant 1. It encodes isoform gamma which has a shorter N-terminus compared to isoform alpha.
    Source sequence(s)
    AB451409, AC005013, AC006367, BQ130001, L05913
    Consensus CDS
    CCDS43562.1
    UniProtKB/Swiss-Prot
    Q02930
    Related
    ENSP00000379593.2, ENST00000396299.6
    Conserved Domains (1) summary
    cd14687
    Location:344403
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    28299321..28825894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012809.1XP_016868298.1  cyclic AMP-responsive element-binding protein 5 isoform X4

    Conserved Domains (1) summary
    cd14687
    Location:370429
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  2. XM_005249906.1XP_005249963.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005249963.1

    UniProtKB/Swiss-Prot
    Q02930
    Conserved Domains (1) summary
    cd14687
    Location:370429
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  3. XM_017012806.1XP_016868295.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q02930
    Conserved Domains (1) summary
    cd14687
    Location:370429
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  4. XM_011515618.2XP_011513920.1  cyclic AMP-responsive element-binding protein 5 isoform X7

  5. XM_017012807.1XP_016868296.1  cyclic AMP-responsive element-binding protein 5 isoform X2

  6. XM_017012808.1XP_016868297.1  cyclic AMP-responsive element-binding protein 5 isoform X3

    UniProtKB/Swiss-Prot
    Q02930
    Conserved Domains (1) summary
    cd14687
    Location:377436
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  7. XM_024447005.1XP_024302773.1  cyclic AMP-responsive element-binding protein 5 isoform X5

    Related
    ENSP00000387197.1, ENST00000409603.5
    Conserved Domains (1) summary
    cd14687
    Location:344403
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  8. XM_017012810.1XP_016868299.1  cyclic AMP-responsive element-binding protein 5 isoform X6

    Conserved Domains (1) summary
    cd14687
    Location:238297
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

RNA

  1. XR_001744893.2 RNA Sequence

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