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CREB5 cAMP responsive element binding protein 5 [ Homo sapiens (human) ]

Gene ID: 9586, updated on 13-Apr-2025

Summary

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Official Symbol
CREB5provided by HGNC
Official Full Name
cAMP responsive element binding protein 5provided by HGNC
Primary source
HGNC:HGNC:16844
See related
Ensembl:ENSG00000146592 MIM:618262; AllianceGenome:HGNC:16844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CREB-5; CREBPA; CRE-BPA
Summary
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 3.3), brain (RPKM 3.0) and 22 other tissues See more
Orthologs
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Genomic context

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See CREB5 in Genome Data Viewer
Location:
7p15.1-p14.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (28299321..28825894)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (28436682..28963385)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (28338940..28865511)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene JAZF zinc finger 1 Neighboring gene MPRA-validated peak6455 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25794 Neighboring gene JAZF1 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:28330425-28331392 and GRCh37_chr7:28331393-28332360 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:28332361-28333326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28350942-28351442 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:28398093-28398687 Neighboring gene peptidylprolyl isomerase A pseudogene 80 Neighboring gene Sharpr-MPRA regulatory region 5389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25797 Neighboring gene Sharpr-MPRA regulatory region 14916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18046 Neighboring gene VISTA enhancer hs1604 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:28651065-28652264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28682874-28683374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28683375-28683875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:28725036-28725544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25799 Neighboring gene ribosomal protein S2 pseudogene 30 Neighboring gene NANOG hESC enhancer GRCh37_chr7:28808272-28808863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28832834-28833543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:28877832-28878523 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18047 Neighboring gene Sharpr-MPRA regulatory region 6215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29025827-29026326 Neighboring gene CPVL antisense RNA 2 Neighboring gene TLR4 interactor with leucine rich repeats Neighboring gene carboxypeptidase vitellogenic like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. CREB5 promotes invasiveness and metastasis in colorectal cancer by directly activating MET. Wang S, et al. J Exp Clin Cancer Res, 2020 Aug 25. PMID 32843066, Free PMC Article
  2. Involvement of the CREB5 regulatory network in colorectal cancer metastasis. Qi L, et al. Yi Chuan, 2014 Jul. PMID 25076032
  3. Identification of CREB5 as a prognostic and immunotherapeutic biomarker in glioma through multi-omics pan-cancer analysis. Wu Z, et al. Comput Biol Med, 2024 May. PMID 38547657
  4. Identification of a Novel Genetic Marker for Risk of Degenerative Rotator Cuff Disease Surgery in the UK Biobank. Yanik EL, et al. J Bone Joint Surg Am, 2021 Jul 21. PMID 33979311, Free PMC Article
  5. LOC401317, a p53-regulated long non-coding RNA, inhibits cell proliferation and induces apoptosis in the nasopharyngeal carcinoma cell line HNE2. Gong Z, et al. PLoS One, 2014. PMID 25422887, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dysregulation of CREB5 Impairs Decidualization and Maternal-Fetal Interactions by Inhibiting Autophagy in Recurrent Spontaneous Abortion.
    Title: Dysregulation of CREB5 Impairs Decidualization and Maternal-Fetal Interactions by Inhibiting Autophagy in Recurrent Spontaneous Abortion.
  2. RGS1 and CREB5 are direct and common transcriptional targets of ZNF384-fusion proteins.
    Title: RGS1 and CREB5 are direct and common transcriptional targets of ZNF384-fusion proteins.
  3. Identification of CREB5 as a prognostic and immunotherapeutic biomarker in glioma through multi-omics pan-cancer analysis.
    Title: Identification of CREB5 as a prognostic and immunotherapeutic biomarker in glioma through multi-omics pan-cancer analysis.
  4. Plasma microRNA-320c as a Potential Biomarker for the Severity of Knee Osteoarthritis and Regulates cAMP Responsive Element Binding Protein 5 (CREB5) in Chondrocytes.
    Title: Plasma microRNA-320c as a Potential Biomarker for the Severity of Knee Osteoarthritis and Regulates cAMP Responsive Element Binding Protein 5 (CREB5) in Chondrocytes.
  5. SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer.
    Title: SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer.
  6. The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer.
    Title: The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer.
  7. Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease.
    Title: Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease.
  8. Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis.
    Title: Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis.
  9. microRNA-206 prevents hepatocellular carcinoma growth and metastasis via down-regulating CREB5 and inhibiting the PI3K/AKT signaling pathway.
    Title: microRNA-206 prevents hepatocellular carcinoma growth and metastasis via down-regulating CREB5 and inhibiting the PI3K/AKT signaling pathway.
  10. The DNAm levels of CREB5 (cg11301281) were associated with clopidogrel resistance.
    Title: The DNAm levels of CREB5 (cg11301281) were associated with clopidogrel resistance.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
EBI GWAS Catalog
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
EBI GWAS Catalog
Genome-wide association study of co-occurring anxiety in major depression.
EBI GWAS Catalog
Genome-wide meta-analysis for severe diabetic retinopathy.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclic AMP-responsive element-binding protein 5
Names
cAMP response element-binding protein CRE-BPa
cAMP-response element-binding protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011666.3 → NP_001011666.1  cyclic AMP-responsive element-binding protein 5 isoform delta

    See identical proteins and their annotated locations for NP_001011666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks several 5' exons and uses an alternate 5' terminal exon which results in the use of a downstream start codon, compared to variant 1. It encodes isoform delta which is shorter and contains a distinct N-terminus compared to isoform alpha.
    Source sequence(s)
    AC005013, BC059400, BQ130001
    Consensus CDS
    CCDS43563.1
    UniProtKB/TrEMBL
    Q59G47
    Related
    ENSP00000379592.2, ENST00000396298.6
    Conserved Domains (1) summary
    cd14687
    Location:238 → 297
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  2. NM_004904.4 → NP_004895.2  cyclic AMP-responsive element-binding protein 5 isoform beta

    See identical proteins and their annotated locations for NP_004895.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a 5' exon and uses an alternate 5' terminal exon which results in the use of a downstream in-frame start codon, compared to variant 1. It encodes isoform beta which has a shorter N-terminus compared to isoform alpha.
    Source sequence(s)
    AB451409, AC005013, AC006980, BQ130001, L05911
    Consensus CDS
    CCDS5418.1
    UniProtKB/Swiss-Prot
    Q02930
    Related
    ENSP00000379594.2, ENST00000396300.6
    Conserved Domains (1) summary
    cd14687
    Location:370 → 429
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  3. NM_182898.4 → NP_878901.2  cyclic AMP-responsive element-binding protein 5 isoform alpha

    See identical proteins and their annotated locations for NP_878901.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (alpha).
    Source sequence(s)
    AB451409, AC005013, AC006367, BQ130001, L05515
    Consensus CDS
    CCDS5417.1
    UniProtKB/Swiss-Prot
    A8KA51, B4DU13, B5BUH3, C9JK47, Q02930, Q05886, Q06246, Q75N02, Q86UJ9
    Related
    ENSP00000350359.2, ENST00000357727.7
    Conserved Domains (1) summary
    cd14687
    Location:377 → 436
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  4. NM_182899.5 → NP_878902.2  cyclic AMP-responsive element-binding protein 5 isoform gamma

    See identical proteins and their annotated locations for NP_878902.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two 5' exons and uses an alternate 5' terminal exon which results in the use of a downstream in-frame start codon, compared to variant 1. It encodes isoform gamma which has a shorter N-terminus compared to isoform alpha.
    Source sequence(s)
    AB451409, AC005013, AC006367, BQ130001, L05913
    Consensus CDS
    CCDS43562.1
    UniProtKB/Swiss-Prot
    Q02930
    Related
    ENSP00000379593.2, ENST00000396299.6
    Conserved Domains (1) summary
    cd14687
    Location:344 → 403
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    28299321..28825894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012807.2 → XP_016868296.1  cyclic AMP-responsive element-binding protein 5 isoform X2

  2. XM_017012808.2 → XP_016868297.1  cyclic AMP-responsive element-binding protein 5 isoform X3

    UniProtKB/Swiss-Prot
    A8KA51, B4DU13, B5BUH3, C9JK47, Q02930, Q05886, Q06246, Q75N02, Q86UJ9
    Conserved Domains (1) summary
    cd14687
    Location:377 → 436
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  3. XM_017012806.2 → XP_016868295.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q02930
    Conserved Domains (1) summary
    cd14687
    Location:370 → 429
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  4. XM_005249906.2 → XP_005249963.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005249963.1

    UniProtKB/Swiss-Prot
    Q02930
    Conserved Domains (1) summary
    cd14687
    Location:370 → 429
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  5. XM_024447005.2 → XP_024302773.1  cyclic AMP-responsive element-binding protein 5 isoform X5

    Related
    ENSP00000387197.1, ENST00000409603.5
    Conserved Domains (1) summary
    cd14687
    Location:344 → 403
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  6. XM_047421068.1 → XP_047277024.1  cyclic AMP-responsive element-binding protein 5 isoform X4

  7. XM_047421069.1 → XP_047277025.1  cyclic AMP-responsive element-binding protein 5 isoform X4

  8. XM_047421067.1 → XP_047277023.1  cyclic AMP-responsive element-binding protein 5 isoform X1

  9. XM_047421070.1 → XP_047277026.1  cyclic AMP-responsive element-binding protein 5 isoform X6

    UniProtKB/TrEMBL
    Q59G47

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    28436682..28963385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359399.1 → XP_054215374.1  cyclic AMP-responsive element-binding protein 5 isoform X8

  2. XM_054359397.1 → XP_054215372.1  cyclic AMP-responsive element-binding protein 5 isoform X1

  3. XM_054359395.1 → XP_054215370.1  cyclic AMP-responsive element-binding protein 5 isoform X7

  4. XM_054359400.1 → XP_054215375.1  cyclic AMP-responsive element-binding protein 5 isoform X5

  5. XM_054359401.1 → XP_054215376.1  cyclic AMP-responsive element-binding protein 5 isoform X4

  6. XM_054359396.1 → XP_054215371.1  cyclic AMP-responsive element-binding protein 5 isoform X2

  7. XM_054359398.1 → XP_054215373.1  cyclic AMP-responsive element-binding protein 5 isoform X1

  8. XM_054359402.1 → XP_054215377.1  cyclic AMP-responsive element-binding protein 5 isoform X6

    UniProtKB/TrEMBL
    Q59G47
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02930.3 GenPept UniProtKB/Swiss-Prot:Q02930

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