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KIF20B kinesin family member 20B [ Homo sapiens (human) ]

Gene ID: 9585, updated on 4-Jul-2021

Summary

Official Symbol
KIF20Bprovided by HGNC
Official Full Name
kinesin family member 20Bprovided by HGNC
Primary source
HGNC:HGNC:7212
See related
Ensembl:ENSG00000138182 MIM:605498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT90; MPP1; KRMP1; MPP-1; MPHOSPH1
Expression
Broad expression in testis (RPKM 5.3), lymph node (RPKM 5.3) and 24 other tissues See more
Orthologs
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Genomic context

See KIF20B in Genome Data Viewer
Location:
10q23.31
Exon count:
33
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (89701590..89774934)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91461347..91534691)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene PANK1 antisense RNA 1 Neighboring gene tigger transposable element derived 2 pseudogene Neighboring gene MT-ND5 pseudogene 42 Neighboring gene uncharacterized LOC105378424 Neighboring gene long intergenic non-protein coding RNA 865

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434B0435, DKFZp434P0810

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables plus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mitotic cytokinetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitotic nuclear division NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in contractile ring IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in spindle midzone ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
kinesin-like protein KIF20B
Names
M-phase phosphoprotein 1
cancer/testis antigen 90
kinesin-related motor interacting with PIN1
mitotic kinesin-like protein
mitotic kinesin-related protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284259.2NP_001271188.1  kinesin-like protein KIF20B isoform 1

    See identical proteins and their annotated locations for NP_001271188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL157389, AL157400
    Consensus CDS
    CCDS60590.1
    UniProtKB/Swiss-Prot
    Q96Q89
    Related
    ENSP00000360793.3, ENST00000371728.8
    Conserved Domains (4) summary
    COG1196
    Location:6291455
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01368
    Location:57477
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:64479
    Kinesin; Kinesin motor domain
    cl19219
    Location:12681357
    DUF342; Protein of unknown function (DUF342)
  2. NM_001382506.1NP_001369435.1  kinesin-like protein KIF20B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL157389, AL157400
    Conserved Domains (4) summary
    COG1196
    Location:5581361
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PTZ00108
    Location:14301716
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd01368
    Location:57406
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    cd21786
    Location:529583
    RBD_KIF20B; RAB6 binding domain (RBD) found in kinesin-like protein KIF20B, and similar proteins
  3. NM_016195.4NP_057279.2  kinesin-like protein KIF20B isoform 2

    See identical proteins and their annotated locations for NP_057279.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to isoform 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AL157389, AL157400
    Consensus CDS
    CCDS7407.1
    UniProtKB/Swiss-Prot
    Q96Q89
    Related
    ENSP00000260753.4, ENST00000260753.8
    Conserved Domains (4) summary
    COG1196
    Location:6731392
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01368
    Location:57477
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:64479
    Kinesin; Kinesin motor domain
    cl19219
    Location:12281317
    DUF342; Protein of unknown function (DUF342)

RNA

  1. NR_168374.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157389, AL157400
  2. NR_168375.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157389, AL157400

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    89701590..89774934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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