CLOCK clock circadian regulator [Homo sapiens (human)] - Gene

Summary

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Official Symbol: CLOCKprovided by HGNC
Official Full Name: clock circadian regulatorprovided by HGNC
Primary source: HGNC:HGNC:2082
See related: Ensembl:ENSG00000134852 MIM:601851
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KAT13D; bHLHe8
Summary: The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression: Ubiquitous expression in testis (RPKM 7.8), thyroid (RPKM 6.2) and 24 other tissues See more
Orthologs: mouse all

Annotation release	Status	Assembly	Chr	Location
109.20190607	current	GRCh38.p13 (GCF_000001405.39)	4	NC_000004.12 (55427901..55547138, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (56294068..56413076, complement)

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

our present research illustrates a novel insight into the circadian clock proteins, CLOCK and BMAL1, which can promote the proliferation, migration, and invasion of cancer cells by affecting the formation of F-actin.
Title: CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cells.
Basal and insulin-stimulated glucose uptake were significantly reduced upon CLOCK depletion. The findings suggest an essential role for the circadian coordination of skeletal muscle glucose homeostasis and lipid metabolism in humans.
Title: Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle.
The antidepressants efficacy of subjects with rs11932595 AA genotype was significantly higher than those with GG+GA genotypes (p = 0.035). But this p-value was not significant after false discovery rate (FDR) adjustment.
Title: The association study of CLOCK gene polymorphisms with antidepressant effect in Chinese with major depressive disorder.
The proliferation of cells significantly decreased after the expression of CLOCK was knocked down in HepG2 cells.
Title: [Elevated expression of CLOCK is associated with poor prognosis in hepatocellular carcinoma].
The present study confirmed that circadian dysfunction is associated with the risk of PD in a Chinese population at the genetic level and provided a potential genetic locus related to PD and CLOCK rs1801260 polymorphism is associated with susceptibility to Parkinson's Disease.
Title: CLOCK rs1801260 Polymorphism is Associated with Susceptibility to Parkinson's Disease in a Chinese Population.
The CLOCK SNP may affect daytime gastric motility less than food stimulation.
Title: The CLOCK 3111T/C single nucleotide polymorphism and daytime fluctuations of gastric motility in healthy young women: A preliminary study.
Significant associations for polymorphisms in CLOCK, NPSR1 and SLC6A3 with traffic crash parameters in professional bus drivers were found.
Title: [Polymorphisms in Sleep and Cognitive Function Related Genes are Associated with Vehicle Crash History in Shift Working Bus Drivers].
As a novel CLOCK-dependent diurnal gene, TIMP3 inhibits the expression of inflammatory cytokines that are up-regulated by UV irradiation in human keratinocytes.
Title: TIMP3 is a CLOCK-dependent diurnal gene that inhibits the expression of UVB-induced inflammatory cytokines in human keratinocytes.
the CLOCK gene polymorphism is one of factors determining elastic properties of vascular wall
Title: [Circadian CLOCK Gene Variants, Parameters of Arterial Stiffness and Blood Pressure Levels in Subjects Without Arterial Hypertension].
Rhythmic luciferase activity from clock gene luciferase reporter cells lines was used to test the effect of p38 MAPK inhibition on clock properties as determined using the damped sine fit and Levenberg-Marquardt algorithm.Glioma treatment with p38 MAPK inhibitors may be more effective and less toxic if administered at the appropriate time of the day.
Title: Inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness.

Submit: New GeneRIF Correction See all GeneRIFs (176)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genome-wide association scan for five major dimensions of personality. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of clock homolog (mouse, CLOCK) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
Chromatin organization, organism-specific biosystem (from REACTOME)
Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
Circadian Clock, organism-specific biosystem (from REACTOME)
Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
Circadian rhythm, organism-specific biosystem (from KEGG)
Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
Circadian rhythm, conserved biosystem (from KEGG)
Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
Circadian rhythm pathway, organism-specific biosystem (from Pathway Interaction Database)
Circadian rhythm pathway, organism-specific biosystem
Circadian rhythm pathway
Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystem (from WikiPathways)
Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
Dopaminergic synapse, organism-specific biosystem (from KEGG)
Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Dopaminergic synapse, conserved biosystem (from KEGG)
Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
HATs acetylate histones, organism-specific biosystem (from REACTOME)
HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Melatonin metabolism and effects, organism-specific biosystem (from WikiPathways)
Melatonin metabolism and effects, organism-specific biosystemMelatonin is an important regulator of circadian rythmus and influences also insulin secretion, immune function, retinal function and neuroprotection. The synthesis starts with the amino acid tryptop...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
PPARA activates gene expression, organism-specific biosystem (from REACTOME)
PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
RORA activates gene expression, organism-specific biosystem (from REACTOME)
RORA activates gene expression, organism-specific biosystemAs inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-R80639 (e-PCR)
- UniSTS:75273

SHGC-50712 (e-PCR)
- UniSTS:37

G54151 (e-PCR)
- UniSTS:109388

SHGC-59220 (e-PCR)
- UniSTS:25995

SHGC-67841 (e-PCR)
- UniSTS:49806

SHGC-106039 (e-PCR)
- UniSTS:169617

G16718 (e-PCR)
- UniSTS:75424

PMC55343P8 (e-PCR)
- UniSTS:273331

RH121148 (e-PCR)
- UniSTS:134143

Homology

Homologs of the CLOCK gene: The CLOCK gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 266 organisms have orthologs with human gene CLOCK
Orthologs

Clone Names

FLJ39000, FLJ42446, KIAA0334, DKFZp686I23208

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
DNA-binding transcription factor activity, RNA polymerase II-specific	ISM Inferred from Sequence Model more info	PubMed
DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
DNA-binding transcription factor activity, RNA polymerase II-specific	NAS Non-traceable Author Statement more info	PubMed
E-box binding	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II distal enhancer sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
RNA polymerase II proximal promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
chromatin DNA binding	ISS Inferred from Sequence or Structural Similarity more info
histone acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein dimerization activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
DNA damage checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to ionizing radiation	IDA Inferred from Direct Assay more info	PubMed
circadian regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
circadian rhythm	TAS Traceable Author Statement more info
histone acetylation	IEA Inferred from Electronic Annotation more info
negative regulation of glucocorticoid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of transcription, DNA-templated	ISS Inferred from Sequence or Structural Similarity more info
photoperiodism	TAS Traceable Author Statement more info	PubMed
positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-templated	ISS Inferred from Sequence or Structural Similarity more info
proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
protein acetylation	IDA Inferred from Direct Assay more info	PubMed
regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
regulation of hair cycle	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
regulation of transcription, DNA-templated	ISS Inferred from Sequence or Structural Similarity more info
regulation of type B pancreatic cell development	ISS Inferred from Sequence or Structural Similarity more info
response to redox state	IDA Inferred from Direct Assay more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed
spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
chromatoid body	ISS Inferred from Sequence or Structural Similarity more info
chromosome	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
nucleoplasm	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
transcription factor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: circadian locomoter output cycles protein kaput

Names: circadian locomoter output cycles kaput protein; class E basic helix-loop-helix protein 8; clock homolog

NP_001254772.1

EC 2.3.1.48

NP_004889.1

EC 2.3.1.48

XP_005265844.1

EC 2.3.1.48

XP_011532711.1

EC 2.3.1.48

XP_011532712.1

EC 2.3.1.48

XP_011532713.1

EC 2.3.1.48

XP_016864343.1

EC 2.3.1.48

XP_016864344.1

EC 2.3.1.48

XP_024310052.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001267843.1 → NP_001254772.1 circadian locomoter output cycles protein kaput

See identical proteins and their annotated locations for NP_001254772.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC069200, BC041878

Consensus CDS

CCDS3500.1

UniProtKB/Swiss-Prot

O15516

UniProtKB/TrEMBL

Q3ZCT4

Related

ENSP00000370723.1, ENST00000381322.5

Conserved Domains (4) summary

cd00083
Location:32 → 86

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam00989
Location:109 → 175

PAS; PAS fold

pfam09606
Location:496 → 686

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl25986
Location:274 → 377

PAS_3; PAS fold
NM_004898.4 → NP_004889.1 circadian locomoter output cycles protein kaput

See identical proteins and their annotated locations for NP_004889.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC069200, AK223549, DA658950

Consensus CDS

CCDS3500.1

UniProtKB/Swiss-Prot

O15516

UniProtKB/TrEMBL

Q53EU0

Related

ENSP00000426983.1, ENST00000513440.6

Conserved Domains (4) summary

cd00083
Location:32 → 86

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam00989
Location:109 → 175

PAS; PAS fold

pfam09606
Location:496 → 686

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl25986
Location:274 → 377

PAS_3; PAS fold

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p13 Primary Assembly

Range

55427901..55547138 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017008854.1 → XP_016864343.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/Swiss-Prot

O15516

Conserved Domains (4) summary

cd00083
Location:32 → 86

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam00989
Location:109 → 175

PAS; PAS fold

pfam09606
Location:496 → 686

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl25986
Location:274 → 377

PAS_3; PAS fold
XM_011534410.2 → XP_011532712.1 circadian locomoter output cycles protein kaput isoform X1

See identical proteins and their annotated locations for XP_011532712.1

UniProtKB/Swiss-Prot

O15516

Conserved Domains (4) summary

cd00083
Location:32 → 86

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam00989
Location:109 → 175

PAS; PAS fold

pfam09606
Location:496 → 686

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl25986
Location:274 → 377

PAS_3; PAS fold
XM_005265787.2 → XP_005265844.1 circadian locomoter output cycles protein kaput isoform X1

See identical proteins and their annotated locations for XP_005265844.1

UniProtKB/Swiss-Prot

O15516

Conserved Domains (4) summary

cd00083
Location:32 → 86

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam00989
Location:109 → 175

PAS; PAS fold

pfam09606
Location:496 → 686

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl25986
Location:274 → 377

PAS_3; PAS fold
XM_011534411.2 → XP_011532713.1 circadian locomoter output cycles protein kaput isoform X1

See identical proteins and their annotated locations for XP_011532713.1

UniProtKB/Swiss-Prot

O15516

Conserved Domains (4) summary

cd00083
Location:32 → 86

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam00989
Location:109 → 175

PAS; PAS fold

pfam09606
Location:496 → 686

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl25986
Location:274 → 377

PAS_3; PAS fold
XM_024454284.1 → XP_024310052.1 circadian locomoter output cycles protein kaput isoform X1

Conserved Domains (4) summary

cd00083
Location:32 → 86

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam00989
Location:109 → 175

PAS; PAS fold

pfam09606
Location:496 → 686

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl25986
Location:274 → 377

PAS_3; PAS fold
XM_011534409.2 → XP_011532711.1 circadian locomoter output cycles protein kaput isoform X1

See identical proteins and their annotated locations for XP_011532711.1

UniProtKB/Swiss-Prot

O15516

Conserved Domains (4) summary

cd00083
Location:32 → 86

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam00989
Location:109 → 175

PAS; PAS fold

pfam09606
Location:496 → 686

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl25986
Location:274 → 377

PAS_3; PAS fold
XM_017008855.1 → XP_016864344.1 circadian locomoter output cycles protein kaput isoform X2