U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) [ Homo sapiens (human) ]

Gene ID: 957, updated on 26-Oct-2022

Summary

Official Symbol
ENTPD5provided by HGNC
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 5 (inactive)provided by HGNC
Primary source
HGNC:HGNC:3367
See related
Ensembl:ENSG00000187097 MIM:603162; AllianceGenome:HGNC:3367
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCPH; CD39L4; NTPDase-5
Summary
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]
Expression
Broad expression in liver (RPKM 43.1), colon (RPKM 29.4) and 18 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ENTPD5 in Genome Data Viewer
Location:
14q24.3
Exon count:
23
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (73955329..74019288, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68162983..68226953, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74422032..74485991, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene prostaglandin reductase 2 Neighboring gene zinc finger protein 410 Neighboring gene FAM161 centrosomal protein B Neighboring gene coenzyme Q6, monooxygenase Neighboring gene ribosomal protein L41 pseudogene 4 Neighboring gene Sharpr-MPRA regulatory regions 4216 and 10298 Neighboring gene basal body orientation factor 1 Neighboring gene aldehyde dehydrogenase 6 family member A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC163357, MGC163359

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables CDP phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GDP phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GDP phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables IDP phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables UDP phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables UDP phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nucleoside diphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_positive_effect 'de novo' post-translational protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in UDP catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_positive_effect UDP-glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nucleoside diphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_positive_effect protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nucleoside diphosphate phosphatase ENTPD5
Names
CD39 antigen-like 4
CD39-like 4
ER-UDPase
GDPase ENTPD5
NTPDase 5
Pcph proto-oncogene protein
UDPase ENTPD5
guanosine-diphosphatase ENTPD5
inosine diphosphate phosphatase ENTPD5
nucleoside diphosphatase
proto-oncogene CPH
uridine-diphosphatase ENTPD5
NP_001240.1
NP_001308913.1
NP_001308914.1
NP_001308915.1
NP_001308916.1
NP_001308917.1
NP_001317118.1
NP_001369185.1
NP_001369186.1
NP_001369187.1
NP_001369188.1
NP_001369189.1
NP_001369191.1
NP_001369192.1
XP_016877303.1
XP_016877305.1
XP_024305526.1
XP_047287930.1
XP_047287931.1
XP_047287932.1
XP_047287933.1
XP_047287934.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001249.5NP_001240.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001240.1

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    O75356, Q96RX0
    UniProtKB/TrEMBL
    A0A024R6D3
    Related
    ENSP00000335246.6, ENST00000334696.11
    Conserved Domains (1) summary
    cl17037
    Location:39424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. NM_001321984.2NP_001308913.1  nucleoside diphosphate phosphatase ENTPD5 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    UniProtKB/TrEMBL
    A0A024R6B4
    Conserved Domains (1) summary
    cl17037
    Location:39400
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. NM_001321985.3NP_001308914.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    O75356, Q96RX0
    UniProtKB/TrEMBL
    A0A024R6D3
    Conserved Domains (1) summary
    cl17037
    Location:39424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. NM_001321986.3NP_001308915.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    O75356, Q96RX0
    UniProtKB/TrEMBL
    A0A024R6D3
    Conserved Domains (1) summary
    cl17037
    Location:39424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  5. NM_001321987.3NP_001308916.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    O75356, Q96RX0
    UniProtKB/TrEMBL
    A0A024R6D3
    Conserved Domains (1) summary
    cl17037
    Location:39424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  6. NM_001321988.3NP_001308917.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    O75356, Q96RX0
    UniProtKB/TrEMBL
    A0A024R6D3
    Conserved Domains (1) summary
    cl17037
    Location:39424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  7. NM_001330189.2NP_001317118.1  nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484, AW028387
    Consensus CDS
    CCDS81825.1
    UniProtKB/TrEMBL
    G3V4I0
    Conserved Domains (1) summary
    cl17037
    Location:39404
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  8. NM_001382256.1NP_001369185.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    Q96RX0
    UniProtKB/TrEMBL
    A0A024R6D3
    Conserved Domains (1) summary
    cl17037
    Location:39424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  9. NM_001382257.1NP_001369186.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    Q96RX0
    UniProtKB/TrEMBL
    A0A024R6D3
    Conserved Domains (1) summary
    cl17037
    Location:39424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  10. NM_001382258.1NP_001369187.1  nucleoside diphosphate phosphatase ENTPD5 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Conserved Domains (1) summary
    cl17037
    Location:39410
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  11. NM_001382259.1NP_001369188.1  nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS81825.1
    UniProtKB/TrEMBL
    G3V4I0
    Related
    ENSP00000451810.1, ENST00000557325.5
    Conserved Domains (1) summary
    cl17037
    Location:39404
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  12. NM_001382260.1NP_001369189.1  nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS81825.1
    UniProtKB/TrEMBL
    G3V4I0
    Conserved Domains (1) summary
    cl17037
    Location:39404
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  13. NM_001382262.1NP_001369191.1  nucleoside diphosphate phosphatase ENTPD5 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Conserved Domains (1) summary
    cl17037
    Location:39396
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  14. NM_001382263.1NP_001369192.1  nucleoside diphosphate phosphatase ENTPD5 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Conserved Domains (1) summary
    cl17037
    Location:39377
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    73955329..74019288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431975.1XP_047287931.1  nucleoside diphosphate phosphatase ENTPD5 isoform X2

    UniProtKB/TrEMBL
    G3V4I0
  2. XM_047431977.1XP_047287933.1  nucleoside diphosphate phosphatase ENTPD5 isoform X4

  3. XM_017021814.2XP_016877303.1  nucleoside diphosphate phosphatase ENTPD5 isoform X2

    UniProtKB/TrEMBL
    G3V4I0
    Conserved Domains (1) summary
    cl17037
    Location:39404
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. XM_047431976.1XP_047287932.1  nucleoside diphosphate phosphatase ENTPD5 isoform X3

  5. XM_047431974.1XP_047287930.1  nucleoside diphosphate phosphatase ENTPD5 isoform X1

    UniProtKB/Swiss-Prot
    Q96RX0
    UniProtKB/TrEMBL
    A0A024R6D3
  6. XM_017021816.2XP_016877305.1  nucleoside diphosphate phosphatase ENTPD5 isoform X3

    Conserved Domains (1) summary
    cl17037
    Location:39377
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  7. XM_024449758.2XP_024305526.1  nucleoside diphosphate phosphatase ENTPD5 isoform X1

    UniProtKB/Swiss-Prot
    Q96RX0
    UniProtKB/TrEMBL
    A0A024R6D3
    Conserved Domains (1) summary
    cl17037
    Location:39424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  8. XM_047431978.1XP_047287934.1  nucleoside diphosphate phosphatase ENTPD5 isoform X5

    Related
    ENSP00000451591.1, ENST00000553284.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    68162983..68226953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)