Format

Send to:

Choose Destination

GTPBP1 GTP binding protein 1 [ Homo sapiens (human) ]

Gene ID: 9567, updated on 21-Apr-2019

Summary

Official Symbol
GTPBP1provided by HGNC
Official Full Name
GTP binding protein 1provided by HGNC
Primary source
HGNC:HGNC:4669
See related
Ensembl:ENSG00000100226 MIM:602245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP1; GP-1; HSPC018
Summary
This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 26.4), spleen (RPKM 10.5) and 25 other tissues See more
Orthologs

Genomic context

See GTPBP1 in Genome Data Viewer
Location:
22q13.1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (38704561..38738265)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39101733..39129592)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene chibby family member 1, beta catenin antagonist Neighboring gene translocase of outer mitochondrial membrane 22 Neighboring gene Josephin domain containing 1 Neighboring gene peroxiredoxin 3 pseudogene 1 Neighboring gene Sad1 and UNC84 domain containing 2 Neighboring gene dynein axonemal light chain 4 Neighboring gene neuronal pentraxin receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20069

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA binding HDA PubMed 
Process Evidence Code Pubs
GTP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic exosome (RNase complex) ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
GTP-binding protein 1
Names
G-protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004286.5NP_004277.2  GTP-binding protein 1

    See identical proteins and their annotated locations for NP_004277.2

    Status: REVIEWED

    Source sequence(s)
    AK095950, BC001701, BC014075, BC016030, BF001482
    Consensus CDS
    CCDS13977.2
    UniProtKB/Swiss-Prot
    O00178
    Related
    ENSP00000216044.5, ENST00000216044.10
    Conserved Domains (1) summary
    cl27768
    Location:48574
    SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    38704561..38738265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530537.2XP_011528839.1  GTP-binding protein 1 isoform X3

    Conserved Domains (4) summary
    cd04165
    Location:170394
    GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
    COG5258
    Location:48582
    GTPBP1; GTPase [General function prediction only]
    cd03694
    Location:403489
    GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
    cd03708
    Location:495581
    GTPBP_III; Domain III of the GP-1 family of GTPases
  2. XM_017029099.2XP_016884588.1  GTP-binding protein 1 isoform X1

  3. XM_017029100.2XP_016884589.1  GTP-binding protein 1 isoform X2

  4. XM_017029103.2XP_016884592.1  GTP-binding protein 1 isoform X6

  5. XM_017029102.2XP_016884591.1  GTP-binding protein 1 isoform X5

  6. XM_017029101.2XP_016884590.1  GTP-binding protein 1 isoform X4

RNA

  1. XR_937969.2 RNA Sequence

  2. XR_937967.2 RNA Sequence

  3. XR_001755376.1 RNA Sequence

  4. XR_001755377.2 RNA Sequence

  5. XR_001755378.1 RNA Sequence

Support Center