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LCMVsSgp2 nucleoprotein [ Mammarenavirus choriomeningitidis ]

Gene ID: 956592, updated on 18-Jul-2024
Gene symbol
LCMVsSgp2
Gene description
nucleoprotein
Locus tag
LCMVsSgp2
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mammarenavirus choriomeningitidis
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Ellioviricetes; Bunyavirales; Arenaviridae; Mammarenavirus
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Location:
segment: S
Sequence:
NC_004294.1 (1639..3315, complement)

NC_004294.1Genomic Context describing neighboring genes Neighboring gene envelope glycoprotein

Genomic Sequence:
NC_004294.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Single nucleoprotein residue modulates arenavirus replication complex formation. Knopp KA, et al. mBio, 2015 Apr 28. PMID 25922393, Free PMC Article
  2. D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis. Ortiz-Riaño E, et al. Viruses, 2012 Oct 16. PMID 23202457, Free PMC Article
  3. Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function. Ortiz-Riaño E, et al. J Virol, 2012 Mar. PMID 22258244, Free PMC Article
  4. The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response. Ortiz-Riaño E, et al. J Virol, 2011 Dec. PMID 21976642, Free PMC Article
  5. Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus. Martínez-Sobrido L, et al. J Virol, 2009 Nov. PMID 19710144, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The viral nucleoprotein associates with double-stranded RNA (dsRNA)-activated protein kinase (PKR), a well-characterized antiviral protein that inhibits cap-dependent protein translation initiation via phosphorylation of eIF2alpha.
    Title: A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR).
  2. Immunofluorescence analysis demonstrated that T206 is required for the formation of the punctate replication and transcription complexes that are typically observed during lymphocytic choriomeningitis virus infection.
    Title: Single nucleoprotein residue modulates arenavirus replication complex formation.
  3. study demonstrates the role of the amino acid residue D471 in the self-association of lymphocytic choriomeningitis virus nucleoprotein; also document the dominant negative effect of D471G mutation on viral infection
    Title: D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis.
  4. Self-association of nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function.
    Title: Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function.
  5. The lymphocytic choriomeningitis virus nucleoprotein domain that interacted with Z overlapped with a previously documented C-terminal domain that counteracts the host type I interferon (IFN) response.
    Title: The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response.
  6. study mapped the regions and specific amino acid residues within nucleoprotein (NP) involved in its anti-IFN activity; identified a region spanning residues 382 to 386 as playing a critical role in the IFN-counteracting activity of NP
    Title: Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus.
  7. Keratin 1, an intermediate filament network component, is the binding partner of the lymphocytic choriomeningitis virus nucleoprotein.
    Title: The nucleoprotein of lymphocytic choriomeningitis virus facilitates spread of persistent infection through stabilization of the keratin network.
  8. Absence of early nucleoprotein (NP)-specific cytotoxic T cells allows LCMV to replicate to higher levels resulting in severely impaired clearance in NP-tolerant mice.
    Title: Absence of CTL responses to early viral antigens facilitates viral persistence.
  9. expression of the LCMV nucleoprotein (NP) is sufficient to inhibit both IFN production and nuclear translocation of IRF-3
    Title: Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus.
Submit: New GeneRIF Correction
Preferred Names
nucleoprotein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004294.1 Reference assembly

    Range
    1639..3315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_694852.1 nucleoprotein [Mammarenavirus choriomeningitidis]

    See identical proteins and their annotated locations for NP_694852.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09992, Q49K86
    UniProtKB/TrEMBL
    A0A059U6M5, A0A218M2F8, I1TPX8
Nucleotide Protein
Heading Accession and Version

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