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LASVsSgp2 glycoprotein [ Mammarenavirus lassaense ]

Gene ID: 956585, updated on 16-Jun-2026
Gene symbol
LASVsSgp2
Gene description
glycoprotein
Locus tag
LASVsSgp2
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mammarenavirus lassaense (strain: Josiah)
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Ellioviricetes; Bunyavirales; Arenaviridae; Mammarenavirus
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Location:
segment: S
Sequence:
NC_004296.1 (1872..3347, complement)

NC_004296.1Genomic Context describing neighboring genes Neighboring gene nucleoprotein

Genomic Sequence:
NC_004296.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Inter-Lineage Variation of Lassa Virus Glycoprotein Epitopes: A Challenge to Lassa Virus Vaccine Development. Ibukun FI. Viruses, 2020 Mar 31. PMID 32244402, Free PMC Article
  2. Differential Antibody-Based Immune Response against Isolated GP1 Receptor-Binding Domains from Lassa and Junín Viruses. Borenstein-Katz A, et al. J Virol, 2019 Apr 15. PMID 30728269, Free PMC Article
  3. Uncoupling GP1 and GP2 expression in the Lassa virus glycoprotein complex: implications for GP1 ectodomain shedding. Illick MM, et al. Virol J, 2008 Dec 23. PMID 19105844, Free PMC Article
  4. Mutational Analysis of Lassa Virus Glycoprotein Highlights Regions Required for Alpha-Dystroglycan Utilization. Acciani M, et al. J Virol, 2017 Sep 15. PMID 28679759, Free PMC Article
  5. Molecular Mechanism for LAMP1 Recognition by Lassa Virus. Cohen-Dvashi H, et al. J Virol, 2015 Aug. PMID 25972533, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inter-Lineage Variation of Lassa Virus Glycoprotein Epitopes: A Challenge to Lassa Virus Vaccine Development.
    Title: Inter-Lineage Variation of Lassa Virus Glycoprotein Epitopes: A Challenge to Lassa Virus Vaccine Development.
  2. mice develop nonproductive immune responses against GP1 from Lassa virus, which is in contrast to the effective neutralizing responses that GP1 from Junin virus elicits. Thus, GP1 from Lassa virus is indeed an immunological decoy and GP1 from Junin virus may serve as a constituent of a future vaccine.
    Title: Differential Antibody-Based Immune Response against Isolated GP1 Receptor-Binding Domains from Lassa and Junín Viruses.
  3. The data suggest that the alpha-dystroglycan binding site on Lassa virus GP1 is found at the top central core of the GP trimer.
    Title: Mutational Analysis of Lassa Virus Glycoprotein Highlights Regions Required for Alpha-Dystroglycan Utilization.
  4. A unique triad of histidines of Lassa Virus GP1 forms a binding site for host LAMP1.
    Title: Molecular Mechanism for LAMP1 Recognition by Lassa Virus.
  5. implicate GP1 as a chaperone for the correct processing and shuttling of GP2 to the cell surface, and suggest that native GPC SP plays a role in this process
    Title: Uncoupling GP1 and GP2 expression in the Lassa virus glycoprotein complex: implications for GP1 ectodomain shedding.
Submit: New GeneRIF Correction

Homology

Preferred Names
glycoprotein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004296.1 Reference assembly

    Range
    1872..3347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_694870.1 glycoprotein [Mammarenavirus lassaense]

    See identical proteins and their annotated locations for NP_694870.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08669
    UniProtKB/TrEMBL
    F1D8K8, Q6GWS0, Q6Y627
    Conserved Domains (1) summary
    pfam00798
    Location:1 → 484
    Arena_glycoprot; Arenavirus glycoprotein
Protein Accession Links
GenPept Link UniProtKB Link
AAA46283.1
AAA46286.1
AAT49004.1
ADY11068.1
ADY11070.1
AEY85213.1
APT69592.1
APT69605.1
APT69609.1
APT69664.1
CAP40169.1
QST04903.1

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