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RVFVsSgp1 NS protein [ Rift Valley fever virus ]

Gene ID: 956561, discontinued on 16-Aug-2010
  • This record was discontinued.
Gene symbol
RVFVsSgp1
Gene description
NS protein
Locus tag
RVFVsSgp1
Gene type
protein coding
RefSeq status
Provisional
Organism
Rift Valley fever virus (strain: MM12)
Lineage
Viruses; ssRNA negative-strand viruses; Bunyaviridae; Phlebovirus
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Location:
segment: segment S
Sequence:
NC_002045.1 (35..832)
Genomic Sequence:
NC_002045.1

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NS interacts with some specific DNA regions of the host genome such as clusters of pericentromeric gamma-satellite sequence and induces chromosome cohesion and segregation defects in infected cells.
    Title: Nonstructural NSs protein of rift valley fever virus interacts with pericentromeric DNA sequences of the host cell, inducing chromosome cohesion and segregation defects.
  2. the 2 distinct functions of the NSs: suppression of host transcription and the downregulation of PKR, work together to prevent host innate antiviral functions, allowing efficient replication & survival of RVFV in infected mammalian hosts
    Title: Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation.
  3. NSs proteins of the related but less virulent sandfly fever Sicilian virus and La Crosse virus, in contrast, had no such anti-double-stranded RNA-dependent protein kinase activity despite being efficient suppressors of IFN induction
    Title: NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase.
Submit: New GeneRIF Correction
Names
NS protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

mRNA and Protein(s)

  1. NP_049343.1 NS protein [Rift Valley fever virus]

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
MNVURV.1