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ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 [ Homo sapiens (human) ]

Gene ID: 956, updated on 7-Jun-2020

Summary

Official Symbol
ENTPD3provided by HGNC
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 3provided by HGNC
Primary source
HGNC:HGNC:3365
See related
Ensembl:ENSG00000168032 MIM:603161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HB6; CD39L3; NTPDase-3
Summary
This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]
Expression
Broad expression in urinary bladder (RPKM 4.1), thyroid (RPKM 2.0) and 20 other tissues See more
Orthologs

Genomic context

See ENTPD3 in Genome Data Viewer
Location:
3p22.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (40387182..40428744)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (40428647..40470110)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 1B Neighboring gene phosphoglycerate mutase 1 pseudogene 3 Neighboring gene ENTPD3 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7904 Neighboring gene ribosomal protein L14 Neighboring gene zinc finger protein 619

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ93839

Gene Ontology Provided by GOA

Function Evidence Code Pubs
8-oxo-dGTP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
dATP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
dCTP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
dGTP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
dTTP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
dUTP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleoside-diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
nucleoside-triphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
nucleobase-containing small molecule catabolic process TAS
Traceable Author Statement
more info
 
nucleoside diphosphate catabolic process IEA
Inferred from Electronic Annotation
more info
 
nucleoside triphosphate catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ectonucleoside triphosphate diphosphohydrolase 3
Names
CD39 antigen-like 3
NTPDase 3
ecto-ATP diphosphohydrolase 3
ecto-ATPDase 3
ecto-ATPase 3
ecto-apyrase 3
NP_001239.2
NP_001278889.1
NP_001278890.1
XP_011532568.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047041.1 RefSeqGene

    Range
    5029..46589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001248.4NP_001239.2  ectonucleoside triphosphate diphosphohydrolase 3 isoform 1

    See identical proteins and their annotated locations for NP_001239.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC104186, AF039917, DA209533
    Consensus CDS
    CCDS2691.1
    UniProtKB/Swiss-Prot
    O75355
    Related
    ENSP00000301825.3, ENST00000301825.8
    Conserved Domains (1) summary
    cl17037
    Location:56478
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. NM_001291960.2NP_001278889.1  ectonucleoside triphosphate diphosphohydrolase 3 isoform 1

    See identical proteins and their annotated locations for NP_001278889.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC104186, AK313322
    Consensus CDS
    CCDS2691.1
    UniProtKB/Swiss-Prot
    O75355
    Related
    ENSP00000401565.1, ENST00000456402.5
    Conserved Domains (1) summary
    cl17037
    Location:56478
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. NM_001291961.2NP_001278890.1  ectonucleoside triphosphate diphosphohydrolase 3 isoform 2

    See identical proteins and their annotated locations for NP_001278890.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and includes a different terminal 3' exon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC104186, BC029869
    Consensus CDS
    CCDS74919.1
    UniProtKB/Swiss-Prot
    O75355
    Related
    ENSP00000404671.1, ENST00000445129.1
    Conserved Domains (1) summary
    cl17037
    Location:56448
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    40387182..40428744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534266.3XP_011532568.1  ectonucleoside triphosphate diphosphohydrolase 3 isoform X1

    Conserved Domains (1) summary
    cl17037
    Location:56281
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
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