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MRPL33 mitochondrial ribosomal protein L33 [ Homo sapiens (human) ]

Gene ID: 9553, updated on 10-Oct-2020

Summary

Official Symbol
MRPL33provided by HGNC
Official Full Name
mitochondrial ribosomal protein L33provided by HGNC
Primary source
HGNC:HGNC:14487
See related
Ensembl:ENSG00000243147 MIM:610059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L33mt; C2orf1; RPL33L; MRP-L33
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 150.4), kidney (RPKM 51.5) and 23 other tissues See more
Orthologs

Genomic context

See MRPL33 in Genome Data Viewer
Location:
2p23.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27771719..27779733)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27994584..28002608)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374378 Neighboring gene long intergenic non-protein coding RNA 1460 Neighboring gene ribokinase Neighboring gene BABAM2 antisense RNA 1 Neighboring gene BRISC and BRCA1 A complex member 2 Neighboring gene MYG1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13694, MGC23922, MGC111093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L33, mitochondrial
Names
mitochondrial large ribosomal subunit protein bL33m
NP_004882.1
NP_663303.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004891.4NP_004882.1  39S ribosomal protein L33, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_004882.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AA836397, BC020834, BC090047
    Consensus CDS
    CCDS1761.1
    UniProtKB/Swiss-Prot
    O75394
    Related
    ENSP00000296102.3, ENST00000296102.8
    Conserved Domains (1) summary
    cl00383
    Location:1060
    Ribosomal_L33; Ribosomal protein L33
  2. NM_145330.3NP_663303.1  39S ribosomal protein L33, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_663303.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment, compared to variant 1, that causes a frameshift. It is not known if a protein product is made from this variant.
    Source sequence(s)
    BC090047
    Consensus CDS
    CCDS33167.1
    UniProtKB/Swiss-Prot
    O75394
    Related
    ENSP00000368988.3, ENST00000379666.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27771719..27779733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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