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ATP5MF ATP synthase membrane subunit f [ Homo sapiens (human) ]

Gene ID: 9551, updated on 7-Jun-2020

Summary

Official Symbol
ATP5MFprovided by HGNC
Official Full Name
ATP synthase membrane subunit fprovided by HGNC
Primary source
HGNC:HGNC:848
See related
Ensembl:ENSG00000241468
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATP5J2; ATP5JL
Summary
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of five different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes. Naturally occurring read-through transcription also exists between this gene and the downstream pentatricopeptide repeat domain 1 (PTCD1) gene. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in colon (RPKM 103.6), kidney (RPKM 95.9) and 25 other tissues See more
Orthologs

Genomic context

See ATP5MF in Genome Data Viewer
Location:
7q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (99458158..99466167, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99055784..99063824, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATP5MF-PTCD1 readthrough Neighboring gene BUD31 homolog Neighboring gene pentatricopeptide repeat domain 1 Neighboring gene SAP domain containing ribonucleoprotein pseudogene Neighboring gene cleavage and polyadenylation specific factor 4 Neighboring gene tRNA-Trp (anticodon CCA) 5-1 Neighboring gene zinc finger protein 789 Neighboring gene zinc finger protein 394

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
ATP synthase subunit f, mitochondrial
Names
ATP synthase f chain, mitochondrial
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2
ATP synthase, H+ transporting, mitochondrial Fo complex subunit F2
F1F0-type ATPase subunit f
F1Fo-ATP synthase complex Fo membrane domain f subunit
F1Fo-ATPase synthase f subunit
NP_001003713.1
NP_001003714.1
NP_001034267.1
NP_004880.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003713.3NP_001003713.1  ATP synthase subunit f, mitochondrial isoform 2b

    See identical proteins and their annotated locations for NP_001003713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes a shorter isoform (2b) that is missing an internal segment when compared to isoform 2a.
    Source sequence(s)
    AC073063, BE139254, CD173604, EL952520
    Consensus CDS
    CCDS47654.1
    UniProtKB/Swiss-Prot
    P56134
    Related
    ENSP00000377740.3, ENST00000394186.3
    Conserved Domains (1) summary
    pfam10206
    Location:883
    WRW; Mitochondrial F1F0-ATP synthase, subunit f
  2. NM_001003714.3NP_001003714.1  ATP synthase subunit f, mitochondrial isoform 2c

    See identical proteins and their annotated locations for NP_001003714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes a shorter isoform (2c) that is missing an internal segment when compared to isoform 2a.
    Source sequence(s)
    AC073063, BE139254, CB110074
    Consensus CDS
    CCDS34692.1
    UniProtKB/Swiss-Prot
    P56134
    Related
    ENSP00000352890.4, ENST00000359832.8
    Conserved Domains (1) summary
    pfam10206
    Location:1450
    WRW; Mitochondrial F1F0-ATP synthase, subunit f
  3. NM_001039178.3NP_001034267.1  ATP synthase subunit f, mitochondrial isoform 2d

    See identical proteins and their annotated locations for NP_001034267.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes a shorter isoform (2d) that is missing multiple internal segments when compared to isoform 2a.
    Source sequence(s)
    AC073063, BE139254, CD173604, CD176299
    Consensus CDS
    CCDS47653.1
    UniProtKB/Swiss-Prot
    P56134
    Related
    ENSP00000418197.1, ENST00000488775.5
    Conserved Domains (1) summary
    pfam10206
    Location:844
    WRW; Mitochondrial F1F0-ATP synthase, subunit f
  4. NM_004889.5NP_004880.1  ATP synthase subunit f, mitochondrial isoform 2a

    See identical proteins and their annotated locations for NP_004880.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and it encodes the longest isoform (2a).
    Source sequence(s)
    AF047436
    Consensus CDS
    CCDS5665.1
    UniProtKB/Swiss-Prot
    P56134
    Related
    ENSP00000292475.3, ENST00000292475.7
    Conserved Domains (1) summary
    pfam10206
    Location:1489
    WRW; Mitochondrial F1F0-ATP synthase, subunit f

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    99458158..99466167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001190353.1: Suppressed sequence

    Description
    NM_001190353.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_001190354.1: Suppressed sequence

    Description
    NM_001190354.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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