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ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 [ Homo sapiens (human) ]

Gene ID: 955, updated on 1-Jun-2020

Summary

Official Symbol
ENTPD6provided by HGNC
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 6provided by HGNC
Primary source
HGNC:HGNC:3368
See related
Ensembl:ENSG00000197586 MIM:603160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD39L2; IL6ST2; IL-6SAG; NTPDase-6; dJ738P15.3
Summary
ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in prostate (RPKM 15.7), colon (RPKM 15.3) and 25 other tissues See more
Orthologs

Genomic context

See ENTPD6 in Genome Data Viewer
Location:
20p11.21
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (25195670..25228075)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (25176327..25207365)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene NIPA like domain containing 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10160 Neighboring gene uncharacterized LOC101926889 Neighboring gene uncharacterized LOC105372579 Neighboring gene Sharpr-MPRA regulatory region 4288 Neighboring gene glycogen phosphorylase B Neighboring gene abhydrolase domain containing 12, lysophospholipase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36711, dJ738P15.3,, DKFZp781G2277, DKFZp781K21102

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
nucleoside-triphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
uridine-diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
nucleobase-containing small molecule catabolic process TAS
Traceable Author Statement
more info
 
response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
response to magnesium ion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ectonucleoside triphosphate diphosphohydrolase 6
Names
CD39 antigen-like 2
NTPDase 6
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
interleukin 6 signal transducer-2
NP_001107561.1
NP_001238.3
NP_001304870.1
NP_001309307.1
NP_001309308.1
NP_001309309.1
NP_001309310.1
NP_001309311.1
NP_001309312.1
NP_001309313.1
NP_001309314.1
NP_001309315.1
NP_001309316.1
NP_001309317.1
NP_001309318.1
NP_001309319.1
NP_001309320.1
NP_001309321.1
NP_001309322.1
NP_001309323.1
NP_001309324.1
NP_001309325.1
NP_001309326.1
NP_001309327.1
XP_006723728.1
XP_011527698.1
XP_011527699.1
XP_016883618.1
XP_016883619.1
XP_016883620.1
XP_016883621.1
XP_016883622.1
XP_016883623.1
XP_024307788.1
XP_024307789.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114089.3NP_001107561.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 2

    See identical proteins and their annotated locations for NP_001107561.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, resulting in a distinct 5' UTR and the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus, and is shorter than isoform 1.
    Source sequence(s)
    AL035252, AL834158, BM982256, HY025213
    Consensus CDS
    CCDS46586.1
    UniProtKB/Swiss-Prot
    O75354
    Related
    ENSP00000347084.5, ENST00000354989.9
    Conserved Domains (1) summary
    cl17037
    Location:78460
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. NM_001247.5NP_001238.3  ectonucleoside triphosphate diphosphohydrolase 6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL035252
    Consensus CDS
    CCDS13170.1
    Related
    ENSP00000365840.4, ENST00000376652.9
    Conserved Domains (1) summary
    cl17037
    Location:95477
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. NM_001317941.2NP_001304870.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL035252, AL834158, BC025980, BM982256, HY025213
    Consensus CDS
    CCDS82604.1
    UniProtKB/Swiss-Prot
    O75354
    Related
    ENSP00000353131.2, ENST00000360031.6
    Conserved Domains (1) summary
    cl17037
    Location:94476
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. NM_001322378.1NP_001309307.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256
    Consensus CDS
    CCDS13170.1
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:95477
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  5. NM_001322379.1NP_001309308.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    UniProtKB/TrEMBL
    B4DHS2
    Conserved Domains (1) summary
    cl17037
    Location:1225
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  6. NM_001322380.1NP_001309309.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    Related
    ENSP00000365854.3, ENST00000376666.3
    Conserved Domains (1) summary
    cl17037
    Location:1178
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  7. NM_001322381.1NP_001309310.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:1178
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  8. NM_001322382.1NP_001309311.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AK300514, AL035252, AL834158, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    UniProtKB/TrEMBL
    B4DU64
    Conserved Domains (1) summary
    cl17037
    Location:1259
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  9. NM_001322383.1NP_001309312.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:1259
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  10. NM_001322384.1NP_001309313.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:1259
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  11. NM_001322385.1NP_001309314.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:78412
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  12. NM_001322386.1NP_001309315.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:78426
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  13. NM_001322387.1NP_001309316.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:95429
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  14. NM_001322388.1NP_001309317.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    Consensus CDS
    CCDS82603.1
    UniProtKB/Swiss-Prot
    O75354
    Related
    ENSP00000401895.2, ENST00000433259.6
    Conserved Domains (1) summary
    cl17037
    Location:95303
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  15. NM_001322389.1NP_001309318.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:92440
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  16. NM_001322390.1NP_001309319.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:95443
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  17. NM_001322391.1NP_001309320.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:95443
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  18. NM_001322392.1NP_001309321.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    UniProtKB/TrEMBL
    B4DDM7
    Conserved Domains (1) summary
    cl17037
    Location:77378
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  19. NM_001322393.1NP_001309322.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:78379
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  20. NM_001322394.1NP_001309323.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    UniProtKB/TrEMBL
    B4E1D1
    Conserved Domains (1) summary
    cl17037
    Location:77459
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  21. NM_001322395.1NP_001309324.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:92393
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  22. NM_001322396.1NP_001309325.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:94395
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  23. NM_001322397.1NP_001309326.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256, HY025213
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:95396
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  24. NM_001322398.1NP_001309327.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL035252, BC025980, BM982256
    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:92474
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    25195670..25228075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452021.1XP_024307789.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X6

    Conserved Domains (1) summary
    cl17037
    Location:94442
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_017028132.2XP_016883621.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X7

  3. XM_017028134.1XP_016883623.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X9

  4. XM_017028133.2XP_016883622.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X8

  5. XM_024452020.1XP_024307788.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X3

    Conserved Domains (1) summary
    cl17037
    Location:95477
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  6. XM_011529396.1XP_011527698.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X3

    See identical proteins and their annotated locations for XP_011527698.1

    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:95477
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  7. XM_006723665.2XP_006723728.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X4

    See identical proteins and their annotated locations for XP_006723728.1

    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:94476
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  8. XM_011529397.1XP_011527699.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X4

    See identical proteins and their annotated locations for XP_011527699.1

    UniProtKB/Swiss-Prot
    O75354
    Conserved Domains (1) summary
    cl17037
    Location:94476
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  9. XM_017028129.1XP_016883618.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1

  10. XM_017028130.1XP_016883619.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

  11. XM_017028131.2XP_016883620.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X5

RNA

  1. XR_001754438.2 RNA Sequence

  2. XR_001754437.1 RNA Sequence

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