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TP53I3 tumor protein p53 inducible protein 3 [ Homo sapiens (human) ]

Gene ID: 9540, updated on 15-Apr-2019

Summary

Official Symbol
TP53I3provided by HGNC
Official Full Name
tumor protein p53 inducible protein 3provided by HGNC
Primary source
HGNC:HGNC:19373
See related
Ensembl:ENSG00000115129 MIM:605171
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIG3
Summary
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Expression
Broad expression in esophagus (RPKM 29.3), small intestine (RPKM 17.8) and 24 other tissues See more
Orthologs

Genomic context

See TP53I3 in Genome Data Viewer
Location:
2p23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (24077428..24085767, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24300303..24308085, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene WD repeat and coiled coil containing Neighboring gene FKBP prolyl isomerase 1B Neighboring gene RNA, U6 small nuclear 370, pseudogene Neighboring gene splicing factor 3b subunit 6 Neighboring gene family with sequence similarity 228 member B Neighboring gene profilin family member 4 Neighboring gene uncharacterized LOC105374328

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADPH binding IDA
Inferred from Direct Assay
more info
PubMed 
NADPH:quinone reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
quinone binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
NADP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
quinone oxidoreductase PIG3
Names
p53-induced gene 3 protein
quinone oxidoreductase homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029715.1 RefSeqGene

    Range
    5001..12783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206802.2NP_001193731.1  quinone oxidoreductase PIG3 isoform 2

    See identical proteins and their annotated locations for NP_001193731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a coding exon in the 3' region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. This variant lacks the 5'-most non-coding exon because of alternate splicing, the extension at the 5' end is uncertain.
    Source sequence(s)
    AK223382, AY371700, CN285566
    Consensus CDS
    CCDS56112.1
    UniProtKB/Swiss-Prot
    Q53FA7
    Related
    ENSP00000384414.1, ENST00000407482.5
    Conserved Domains (1) summary
    cl16912
    Location:1205
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
  2. NM_004881.5NP_004872.2  quinone oxidoreductase PIG3 isoform 1

    See identical proteins and their annotated locations for NP_004872.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
    Source sequence(s)
    AK223382, BT007149, CN285566
    Consensus CDS
    CCDS1708.1
    UniProtKB/Swiss-Prot
    Q53FA7
    Related
    ENSP00000238721.4, ENST00000238721.9
    Conserved Domains (1) summary
    cd05276
    Location:1328
    p53_inducible_oxidoreductase; PIG3 p53-inducible quinone oxidoreductase
  3. NM_147184.3NP_671713.1  quinone oxidoreductase PIG3 isoform 1

    See identical proteins and their annotated locations for NP_671713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5'UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC000474, CN285566, DB032484, DB034176
    Consensus CDS
    CCDS1708.1
    UniProtKB/Swiss-Prot
    Q53FA7
    Related
    ENSP00000337834.4, ENST00000335934.8
    Conserved Domains (1) summary
    cd05276
    Location:1328
    p53_inducible_oxidoreductase; PIG3 p53-inducible quinone oxidoreductase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    24077428..24085767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264650.3XP_005264707.1  quinone oxidoreductase PIG3 isoform X2

    See identical proteins and their annotated locations for XP_005264707.1

    UniProtKB/TrEMBL
    B4DMQ7
    Conserved Domains (1) summary
    cl16912
    Location:48239
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
  2. XM_024453249.1XP_024309017.1  quinone oxidoreductase PIG3 isoform X2

    Conserved Domains (1) summary
    cl16912
    Location:48239
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
  3. XM_006712150.2XP_006712213.1  quinone oxidoreductase PIG3 isoform X1

    See identical proteins and their annotated locations for XP_006712213.1

    UniProtKB/Swiss-Prot
    Q53FA7
    Conserved Domains (1) summary
    cl16912
    Location:1205
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
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