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ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 [ Homo sapiens (human) ]

Gene ID: 954, updated on 1-Jun-2020

Summary

Official Symbol
ENTPD2provided by HGNC
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 2provided by HGNC
Primary source
HGNC:HGNC:3364
See related
Ensembl:ENSG00000054179 MIM:602012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD39L1; NTPDase-2
Summary
The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Broad expression in duodenum (RPKM 4.7), prostate (RPKM 4.6) and 17 other tissues See more
Orthologs

Genomic context

See ENTPD2 in Genome Data Viewer
Location:
9q34.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (137048107..137054061, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139942550..139948503, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene chromosome 9 open reading frame 139 Neighboring gene fucosyltransferase 7 Neighboring gene neural proliferation, differentiation and control 1 Neighboring gene uncharacterized LOC105376327 Neighboring gene suppressor APC domain containing 2 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
nucleoside-diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
nucleoside-triphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing small molecule catabolic process TAS
Traceable Author Statement
more info
 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
purine ribonucleoside diphosphate catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basement membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ectonucleoside triphosphate diphosphohydrolase 2
Names
CD39 antigen-like 1
NTPDase 2
ecto-ATP diphosphohydrolase 2
ecto-ATPDase 2
ecto-ATPase 2
NP_001237.1
NP_982293.1
XP_011517514.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029427.1 RefSeqGene

    Range
    4993..10947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001246.4NP_001237.1  ectonucleoside triphosphate diphosphohydrolase 2 isoform 2

    See identical proteins and their annotated locations for NP_001237.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF144748, AL807752, BC035738, CB045339, U91510
    Consensus CDS
    CCDS7025.1
    UniProtKB/Swiss-Prot
    Q9Y5L3
    Related
    ENSP00000312494.5, ENST00000312665.7
    Conserved Domains (1) summary
    cl17037
    Location:39430
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. NM_203468.3NP_982293.1  ectonucleoside triphosphate diphosphohydrolase 2 isoform 1

    See identical proteins and their annotated locations for NP_982293.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF144748, AL807752, BC035738, CB045339
    Consensus CDS
    CCDS7026.1
    UniProtKB/Swiss-Prot
    Q9Y5L3
    Related
    ENSP00000347213.2, ENST00000355097.7
    Conserved Domains (1) summary
    cl17037
    Location:39453
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    137048107..137054061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519212.3XP_011517514.1  ectonucleoside triphosphate diphosphohydrolase 2 isoform X1

    Conserved Domains (1) summary
    cl17037
    Location:31350
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
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