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GMFG glia maturation factor gamma [ Homo sapiens (human) ]

Gene ID: 9535, updated on 7-Jun-2020

Summary

Official Symbol
GMFGprovided by HGNC
Official Full Name
glia maturation factor gammaprovided by HGNC
Primary source
HGNC:HGNC:4374
See related
Ensembl:ENSG00000130755 MIM:604104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GMF-GAMMA
Expression
Broad expression in bone marrow (RPKM 133.3), spleen (RPKM 93.4) and 15 other tissues See more
Orthologs

Genomic context

See GMFG in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (39328359..39336043, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39818999..39826726, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene interferon lambda 1 Neighboring gene leucine rich repeat and fibronectin type III domain containing 1 Neighboring gene sterile alpha motif domain containing 4B Neighboring gene RNA, 7SL, cytoplasmic 566, pseudogene Neighboring gene PAF1 homolog, Paf1/RNA polymerase II complex component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126867

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 complex binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
enzyme activator activity TAS
Traceable Author Statement
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin filament debranching IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glia maturation factor gamma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301008.2NP_001287937.1  glia maturation factor gamma isoform 2

    See identical proteins and their annotated locations for NP_001287937.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AV714415, BC080180, BF974742
    Consensus CDS
    CCDS74364.1
    UniProtKB/Swiss-Prot
    O60234
    UniProtKB/TrEMBL
    M0R1D2
    Related
    ENSP00000471786.1, ENST00000601387.5
    Conserved Domains (1) summary
    cd11283
    Location:289
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins
  2. NM_004877.4NP_004868.1  glia maturation factor gamma isoform 1

    See identical proteins and their annotated locations for NP_004868.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC080180, BF974742
    Consensus CDS
    CCDS12532.1
    UniProtKB/Swiss-Prot
    O60234
    Related
    ENSP00000472249.1, ENST00000597595.6
    Conserved Domains (1) summary
    cd11283
    Location:9130
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    39328359..39336043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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