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TECR trans-2,3-enoyl-CoA reductase [ Homo sapiens (human) ]

Gene ID: 9524, updated on 4-Oct-2020

Summary

Official Symbol
TECRprovided by HGNC
Official Full Name
trans-2,3-enoyl-CoA reductaseprovided by HGNC
Primary source
HGNC:HGNC:4551
See related
Ensembl:ENSG00000099797 MIM:610057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SC2; TER; GPSN2; MRT14
Summary
This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]
Expression
Ubiquitous expression in esophagus (RPKM 95.3), skin (RPKM 93.5) and 25 other tissues See more
Orthologs

Genomic context

See TECR in Genome Data Viewer
Location:
19p13.12
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (14527752..14565980)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14640379..14676792)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene prostaglandin E receptor 1 Neighboring gene GIPC PDZ domain containing family member 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 15 Neighboring gene DnaJ heat shock protein family (Hsp40) member B1 Neighboring gene microRNA 639 Neighboring gene uncharacterized LOC112268253 Neighboring gene NADH:ubiquinone oxidoreductase subunit B7 Neighboring gene RNA, 7SL, cytoplasmic 337, pseudogene Neighboring gene C-type lectin domain containing 17A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of trans-2,3-enoyl-CoA reductase (TECR) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
very-long-chain enoyl-CoA reductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
fatty acid elongation IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
sphingolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very long-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
very long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
very-long-chain enoyl-CoA reductase
Names
epididymis secretory sperm binding protein
glycoprotein, synaptic 2
synaptic glycoprotein SC2
NP_001308099.1
NP_612510.1
XP_006723008.1
XP_011526744.1
XP_024307558.1
XP_024307559.1
XP_024307560.1
XP_024307561.1
XP_024307562.1
XP_024307563.1
XP_024307564.1
XP_024307565.1
XP_024307566.1
XP_024307567.1
XP_024307568.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028336.1 RefSeqGene

    Range
    5028..41414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321170.1NP_001308099.1  very-long-chain enoyl-CoA reductase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK094087, BC013881, DB491783
    UniProtKB/Swiss-Prot
    Q9NZ01
    UniProtKB/TrEMBL
    B3KSQ1
    Conserved Domains (3) summary
    cd01801
    Location:2196
    Tsc13_N; Ubiquitin-like domain of Tsc13
    PLN02560
    Location:38320
    PLN02560; enoyl-CoA reductase
    cl21511
    Location:170323
    PEMT; Phospholipid methyltransferase
  2. NM_138501.6NP_612510.1  very-long-chain enoyl-CoA reductase isoform 1

    See identical proteins and their annotated locations for NP_612510.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC007801, DB491783
    Consensus CDS
    CCDS12313.1
    UniProtKB/Swiss-Prot
    Q9NZ01
    Related
    ENSP00000215567.4, ENST00000215567.10
    Conserved Domains (1) summary
    PLN02560
    Location:23305
    PLN02560; enoyl-CoA reductase

RNA

  1. NR_038103.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC005384, BC007801, DB491783
    Related
    ENST00000642961.1
  2. NR_038104.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site at an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK299134, BC007801, DB491783
    Related
    ENST00000600083.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    14527752..14565980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451793.1XP_024307561.1  very-long-chain enoyl-CoA reductase isoform X4

    Conserved Domains (1) summary
    PLN02560
    Location:44352
    PLN02560; enoyl-CoA reductase
  2. XM_024451792.1XP_024307560.1  very-long-chain enoyl-CoA reductase isoform X3

    Conserved Domains (1) summary
    PLN02560
    Location:44356
    PLN02560; enoyl-CoA reductase
  3. XM_011528442.2XP_011526744.1  very-long-chain enoyl-CoA reductase isoform X10

    Conserved Domains (3) summary
    cd01801
    Location:27102
    Tsc13_N; Ubiquitin-like domain of Tsc13
    PLN02560
    Location:44326
    PLN02560; enoyl-CoA reductase
    cl21511
    Location:176329
    PEMT; Phospholipid methyltransferase
  4. XM_024451790.1XP_024307558.1  very-long-chain enoyl-CoA reductase isoform X1

    Conserved Domains (1) summary
    PLN02560
    Location:55368
    PLN02560; enoyl-CoA reductase
  5. XM_024451794.1XP_024307562.1  very-long-chain enoyl-CoA reductase isoform X5

    Conserved Domains (1) summary
    PLN02560
    Location:38350
    PLN02560; enoyl-CoA reductase
  6. XM_024451795.1XP_024307563.1  very-long-chain enoyl-CoA reductase isoform X6

    Conserved Domains (1) summary
    PLN02560
    Location:38346
    PLN02560; enoyl-CoA reductase
  7. XM_024451799.1XP_024307567.1  very-long-chain enoyl-CoA reductase isoform X11

    Conserved Domains (1) summary
    PLN02560
    Location:1176
    PLN02560; enoyl-CoA reductase
  8. XM_024451796.1XP_024307564.1  very-long-chain enoyl-CoA reductase isoform X8

    Related
    ENST00000597607.5
    Conserved Domains (1) summary
    PLN02560
    Location:23335
    PLN02560; enoyl-CoA reductase
  9. XM_024451797.1XP_024307565.1  very-long-chain enoyl-CoA reductase isoform X9

    Conserved Domains (1) summary
    PLN02560
    Location:23331
    PLN02560; enoyl-CoA reductase
  10. XM_024451791.1XP_024307559.1  very-long-chain enoyl-CoA reductase isoform X2

    Conserved Domains (1) summary
    PLN02560
    Location:55364
    PLN02560; enoyl-CoA reductase
  11. XM_006722945.2XP_006723008.1  very-long-chain enoyl-CoA reductase isoform X7

    Conserved Domains (3) summary
    cd01801
    Location:47114
    Tsc13_N; Ubiquitin-like domain of Tsc13
    PLN02560
    Location:55338
    PLN02560; enoyl-CoA reductase
    cl21511
    Location:188341
    PEMT; Phospholipid methyltransferase
  12. XM_024451800.1XP_024307568.1  very-long-chain enoyl-CoA reductase isoform X12

    Related
    ENSP00000472957.1, ENST00000601187.1
    Conserved Domains (1) summary
    PLN02560
    Location:1150
    PLN02560; enoyl-CoA reductase
  13. XM_024451798.1XP_024307566.1  very-long-chain enoyl-CoA reductase isoform X11

    Conserved Domains (1) summary
    PLN02560
    Location:1176
    PLN02560; enoyl-CoA reductase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004868.1: Suppressed sequence

    Description
    NM_004868.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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