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PAGE4 PAGE family member 4 [ Homo sapiens (human) ]

Gene ID: 9506, updated on 5-Aug-2022

Summary

Official Symbol
PAGE4provided by HGNC
Official Full Name
PAGE family member 4provided by HGNC
Primary source
HGNC:HGNC:4108
See related
Ensembl:ENSG00000101951 MIM:300287; AllianceGenome:HGNC:4108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JM27; JM-27; CT16.7; GAGE-9; GAGEC1; PAGE-1; PAGE-4
Summary
This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Restricted expression toward placenta (RPKM 272.2) See more
Orthologs
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Genomic context

See PAGE4 in Genome Data Viewer
Location:
Xp11.23
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (49829260..49834264)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (49145174..49150178)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (49593863..49598867)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene spalt like transcription factor 1 pseudogene 1 Neighboring gene PAGE family member 1 Neighboring gene Sharpr-MPRA regulatory region 10598 Neighboring gene USP27X divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35184

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleic acid binding EXP
Inferred from Experiment
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
P antigen family member 4
Names
P antigen family, member 4 (prostate associated)
g antigen family C member 1
prostate-associated gene protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318877.1NP_001305806.1  P antigen family member 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC231644, AI093155, AL548759
    Consensus CDS
    CCDS35274.1
    UniProtKB/Swiss-Prot
    O60829, Q6IBI1
    Related
    ENSP00000365311.1, ENST00000376141.5
    Conserved Domains (1) summary
    pfam05831
    Location:1498
    GAGE; GAGE protein
  2. NM_007003.4NP_008934.1  P antigen family member 4

    See identical proteins and their annotated locations for NP_008934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC231644, AL548759, BG435968, DA841276
    Consensus CDS
    CCDS35274.1
    UniProtKB/Swiss-Prot
    O60829, Q6IBI1
    Related
    ENSP00000218068.6, ENST00000218068.7
    Conserved Domains (1) summary
    pfam05831
    Location:1498
    GAGE; GAGE protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    49829260..49834264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442678.1XP_047298634.1  P antigen family member 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6IBI1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    49145174..49150178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)