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XAGE2 X antigen family member 2 [ Homo sapiens (human) ]

Gene ID: 9502, updated on 10-Oct-2019

Summary

Official Symbol
XAGE2provided by HGNC
Official Full Name
X antigen family member 2provided by HGNC
Primary source
HGNC:HGNC:4112
See related
Ensembl:ENSG00000155622 MIM:300416
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT12.2; GAGED3; XAGE-2; XAGE2B
Summary
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in normal testis, and in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer and a germ cell tumor. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward placenta (RPKM 70.1) See more
Orthologs

Genomic context

See XAGE2 in Genome Data Viewer
Location:
Xp11.22
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (52368996..52375683)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52111931..52118826)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 156 member A pseudogene Neighboring gene microRNA 8088 Neighboring gene X antigen family member 5-like Neighboring gene RNA binding motif protein 22 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
X antigen family member 2
Names
G antigen family D member 3
X antigen family, member 2B
cancer/testis antigen 12.2
cancer/testis antigen family 12, member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130777.3NP_570133.1  X antigen family member 2

    See identical proteins and their annotated locations for NP_570133.1

    Status: REVIEWED

    Source sequence(s)
    AJ318880, H53211
    Consensus CDS
    CCDS59525.1
    UniProtKB/Swiss-Prot
    Q96GT9
    UniProtKB/TrEMBL
    A0A024R2A6
    Related
    ENSP00000286049.2, ENST00000286049.3
    Conserved Domains (1) summary
    pfam05831
    Location:1105
    GAGE; GAGE protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    52368996..52375683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530836.2XP_011529138.1  X antigen family member 2 isoform X1

    See identical proteins and their annotated locations for XP_011529138.1

    UniProtKB/Swiss-Prot
    Q96GT9
    UniProtKB/TrEMBL
    A0A024R2A6
    Conserved Domains (1) summary
    pfam05831
    Location:1105
    GAGE; GAGE protein
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