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AKAP5 A-kinase anchoring protein 5 [ Homo sapiens (human) ]

Gene ID: 9495, updated on 27-Nov-2022

Summary

Official Symbol
AKAP5provided by HGNC
Official Full Name
A-kinase anchoring protein 5provided by HGNC
Primary source
HGNC:HGNC:375
See related
Ensembl:ENSG00000179841 MIM:604688; AllianceGenome:HGNC:375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H21; AKAP75; AKAP79
Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 10.3), colon (RPKM 3.6) and 10 other tissues See more
Orthologs
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Genomic context

See AKAP5 in Genome Data Viewer
Location:
14q23.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (64465499..64474503)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (58673265..58682271)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64932217..64941221)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene testis expressed 21, pseudogene Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Neighboring gene Sharpr-MPRA regulatory region 9441 Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene HSPA2 and ZBTB1 antisense RNA 1 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene heat shock protein family A (Hsp70) member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables adenylate cyclase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenylate cyclase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-2 adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutamate receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A binding TAS
Traceable Author Statement
more info
PubMed 
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase A regulatory subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase A regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 2B binding IDA
Inferred from Direct Assay
more info
PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IC
Inferred by Curator
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in excitatory synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein serine/threonine phosphatase complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
A-kinase anchor protein 5
Names
A kinase (PRKA) anchor protein 5
A-kinase anchor protein 79 kDa
A-kinase anchoring protein 75/79
AKAP 79
cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033983.1 RefSeqGene

    Range
    5001..14005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004857.3NP_004848.3  A-kinase anchor protein 5

    See identical proteins and their annotated locations for NP_004848.3

    Status: REVIEWED

    Source sequence(s)
    AL122035, BC057229, BC131516, DA942424
    Consensus CDS
    CCDS9764.1
    UniProtKB/Swiss-Prot
    A2RRB8, P24588
    UniProtKB/TrEMBL
    Q6PG46
    Related
    ENSP00000378207.3, ENST00000394718.4
    Conserved Domains (1) summary
    pfam03832
    Location:77102
    WSK; WSK motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    64465499..64474503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    58673265..58682271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)