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acpH acyl carrier protein phosphodiesterase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949132, updated on 6-Jul-2026
Official Symbol
acpH
Official Full Name
acyl carrier protein phosphodiesterase
Primary source
ECOCYC:EG11095
Locus tag
b0404
See related
ASAP:ABE-0001404
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0398; yajB
Summary
AcpH is required for turnover of the acyl carrier protein (ACP) prosthetic group 4'-phosphopanthetheine at Ser36 in vivo. [More information is available at EcoGene: EG11095]. Acyl carrier protein (ACP) phosphodiesterase is responsible for the cleavage of |FRAME: [More information is available at EcoCyc: EG11095].
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Sequence:
NC_000913.3 (424337..424918, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter ProY Neighboring gene maltodextrin glucosidase Neighboring gene tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase Neighboring gene tRNA-guanine transglycosylase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Acyl carrier protein. IX. Acyl carrier protein hydrolase. Vagelos PR, et al. J Biol Chem, 1967 Apr 25. PMID 4290442
  2. Acyl carrier protein phosphodiesterase (AcpH) of Escherichia coli is a non-canonical member of the HD phosphatase/phosphodiesterase family. Thomas J, et al. Biochemistry, 2007 Jan 9. PMID 17198382
  3. The promoter of the tgt/sec operon in Escherichia coli is preceded by an upstream activation sequence that contains a high affinity FIS binding site. Slany RK, et al. Nucleic Acids Res, 1992 Aug 25. PMID 1508713, Free PMC Article
  4. Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes. Reuter K, et al. J Bacteriol, 1991 Apr. PMID 1706703, Free PMC Article
  5. The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization. Thomas J, et al. J Biol Chem, 2005 Oct 14. PMID 16107329

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACP hydrolyase, also called ACP phosphodiesterase, is encoded by a gene (yajB) that has been renamed acpH
    Title: The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization.
  2. Acyl carrier protein phosphodiesterase is a member of the HD protein family despite the lack of the signature histidine residue.
    Title: Acyl carrier protein phosphodiesterase (AcpH) of Escherichia coli is a non-canonical member of the HD phosphatase/phosphodiesterase family.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables [acyl-carrier-protein] phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [acyl-carrier-protein] phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [acyl-carrier-protein] phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
acyl carrier protein phosphodiesterase
NP_414938.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    424337..424918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414938.1 acyl carrier protein phosphodiesterase

    See identical proteins and their annotated locations for NP_414938.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0H2YWN9
    Conserved Domains (1) summary
    PRK10045
    Location:1 → 193
    PRK10045; ACP phosphodiesterase
Nucleotide Protein
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