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folM dihydromonapterin reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949096, updated on 30-Jul-2025
Official Symbol
folM
Official Full Name
dihydromonapterin reductase
Primary source
ECOCYC:G6862
Locus tag
b1606
See related
ASAP:ABE-0005364
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1601; ydgB
Summary
The folM gene encodes a dihydrofolate reductase. [More information is available at EcoCyc: G6862].
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Sequence:
NC_000913.3 (1680976..1681698)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1471 domain-containing protein YdgH Neighboring gene putative arginine:ornithine antiporter Neighboring gene GlpM family protein Neighboring gene DNA-binding transcriptional regulator RstA Neighboring gene sensor histidine kinase RstB

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that substrate specificity of peptidyl transferase activity of 23S rRNA allows incorporation of beta-alanine analogs into dihydrofolate reductase (folM) at four sites.
    Title: Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids.
  2. Purified FolM in E. coli showed high, NADPH-dependent dihydromonapterin reductase activity.
    Title: FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables dihydrofolate reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydrofolate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydromonapterin reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within 10-formyltetrahydrofolate biosynthetic process EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within folic acid biosynthetic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within pteridine-containing compound biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
dihydromonapterin reductase
NP_416123.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1680976..1681698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416123.1 dihydromonapterin reductase

    See identical proteins and their annotated locations for NP_416123.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7EKB0
    Conserved Domains (1) summary
    PRK06483
    Location:5 → 240
    PRK06483; dihydromonapterin reductase; Provisional
Nucleotide Protein
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