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symE nucleoid-associated protein SymE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949088, updated on 30-Jul-2025
Official Symbol
symE
Official Full Name
nucleoid-associated protein SymE
Primary source
ECOCYC:G7940
Locus tag
b4347
See related
ASAP:ABE-0014253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dinL; ECK4337; sosC; yjiW
Summary
SymE is toxic when overexpressed which leads to inhibition of protein synthesis and RNA degradation (Kawano, 2007). [More information is available at EcoGene: EG12584]. SymE belongs to the AbrB superfamily of proteins, which also contains the antitoxin MazE. [More information is available at EcoCyc: G7940].
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Sequence:
NC_000913.3 (4579499..4579840, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Type IV methyl-directed restriction enzyme EcoKMcrBC subunit Neighboring gene 5-methylcytosine-specific restriction enzyme subunit McrB;mcrB-S Neighboring gene ncRNA Neighboring gene type I restriction enzyme EcoKI specificity subunit Neighboring gene type I restriction enzyme EcoKI methylase subunit Neighboring gene type I restriction enzyme EcoKI endonuclease subunit

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Escherichia coli SymE is a DNA-binding protein that can condense the nucleoid. Thompson MK, et al. Mol Microbiol, 2022 Apr. PMID 34964191, Free PMC Article
  2. Identification of high affinity binding sites for LexA which define new DNA damage-inducible genes in Escherichia coli. Lewis LK, et al. J Mol Biol, 1994 Aug 26. PMID 8057377
  3. Detection of 5'- and 3'-UTR-derived small RNAs and cis-encoded antisense RNAs in Escherichia coli. Kawano M, et al. Nucleic Acids Res, 2005. PMID 15718303, Free PMC Article
  4. Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks. Rooney JP, et al. Genomics, 2009 Jan. PMID 18824089, Free PMC Article
  5. Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Burland V, et al. Nucleic Acids Res, 1995 Jun 25. PMID 7610040, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Escherichia coli SymE is a DNA-binding protein that can condense the nucleoid.
    Title: Escherichia coli SymE is a DNA-binding protein that can condense the nucleoid.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in RNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within SOS response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in bacterial nucleoid DNA packaging IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with bacterial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in bacterial nucleoid IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
nucleoid-associated protein SymE

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4579499..4579840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418767.4 nucleoid-associated protein SymE

    See identical proteins and their annotated locations for NP_418767.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1V2GEX0
    Conserved Domains (1) summary
    PRK13605
    Location:1 → 113
    PRK13605; endoribonuclease SymE; Provisional
Nucleotide Protein
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Gene LinkOut

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