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csgA curlin [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949055, updated on 17-Jul-2025
Official Symbol
csgA
Official Full Name
curlin
Primary source
ECOCYC:EG11489
Locus tag
b1042
See related
ASAP:ABE-0003537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1028
Summary
The csgAB operon is regulated by CsgD. [More information is available at EcoGene: EG11489]. The CsgA protein is the major subunit of curlin; it is actively secreted to the extracellular milieu , where CsgA monomers self-assemble into curli . [More information is available at EcoCyc: EG11489].
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Sequence:
NC_000913.3 (1104447..1104902)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator CsgD Neighboring gene curlin, minor subunit Neighboring gene curlin chaperone Neighboring gene uncharacterized protein YmdA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. NMR insights into the pre-amyloid ensemble and secretion targeting of the curli subunit CsgA. Sewell L, et al. Sci Rep, 2020 May 12. PMID 32398666, Free PMC Article
  2. In vitro polymerization of a functional Escherichia coli amyloid protein. Wang X, et al. J Biol Chem, 2007 Feb 9. PMID 17164238, Free PMC Article
  3. Curli biogenesis and function. Barnhart MM, et al. Annu Rev Microbiol, 2006. PMID 16704339, Free PMC Article
  4. Biofilm formation by Escherichia coli is stimulated by synergistic interactions and co-adhesion mechanisms with adherence-proficient bacteria. Castonguay MH, et al. Res Microbiol, 2006 Jun. PMID 16376056
  5. Oligonucleotide nanostructured surfaces: effect on Escherichia coli curli expression. Cottenye N, et al. Macromol Biosci, 2008 Dec 8. PMID 18683166

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A gut bacterial amyloid promotes alpha-synuclein aggregation and motor impairment in mice.
    Title: A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice.
  2. NMR insights into the pre-amyloid ensemble and secretion targeting of the curli subunit CsgA.
    Title: NMR insights into the pre-amyloid ensemble and secretion targeting of the curli subunit CsgA.
  3. Studies show the common structural features of CsgC and CsgE and the potential implications for general inhibition of amyloid.
    Title: Structural insights into functional amyloid inhibition in Gram -ve bacteria.
  4. CsgA deletion mutant lost its adherence to HTB-9 but continued to adhere to the HUVEC and Vero cells.
    Title: Curli fimbria: an Escherichia coli adhesin associated with human cystitis.
  5. A Monte Carlo study of the early steps of functional amyloid formation of bacterial biofilm, which is primarily formed by aggregates of the protein CsgA, has been presented.
    Title: A Monte Carlo Study of the Early Steps of Functional Amyloid Formation.
  6. Inactivation of the cysH gene results in increased surface adhesion and cell aggregation by activating the expression of the curli-encoding csgBAC operon via phosphoadenosine 59-phosphosulfate accumulation.
    Title: Sulfate assimilation pathway intermediate phosphoadenosine 59-phosphosulfate acts as a signal molecule affecting production of curli fibres in Escherichia coli.
  7. It was thus verified that the reinforcement of csgA gene in the DeltarpoS cells induced the enhanced colonization on the solid surfaces with the increased flagellum and curli expressions.
    Title: Enhanced colonization of rpoS-deficient Escherichia coli cells on solid surfaces by reinforced csgA gene expression.
  8. Substoichiometric concentrations of CsgB induce a change in the mechanism of CsgA aggregation from that of forming amorphous aggregates to that of structured intermediates similar to those of CsgB alone
    Title: The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism.
  9. CsgA polymerization in vitro is preceded by the formation of thin needlelike protofibrils followed by aggregation of the amyloid fibrils.
    Title: Fibrillation of the major curli subunit CsgA under a wide range of conditions implies a robust design of aggregation.
  10. Data describe aspartic acid and glycine residues that function as "gatekeepers" to modulate CsgA polymerization efficiency and potential toxicity.
    Title: Gatekeeper residues in the major curlin subunit modulate bacterial amyloid fiber biogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Homology

Preferred Names
curlin

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1104447..1104902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415560.1 curlin

    See identical proteins and their annotated locations for NP_415560.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P28307
    Conserved Domains (1) summary
    PRK10051
    Location:1 → 151
    csgA; major curlin subunit CsgA
Nucleotide Protein
Heading Accession and Version

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