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cydD glutathione/L-cysteine ABC exporter subunit CydD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949052, updated on 26-Mar-2025

Summary

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Official Symbol
cydD
Official Full Name
glutathione/L-cysteine ABC exporter subunit CydD
Primary source
ECOCYC:EG11405
Locus tag
b0887
See related
ASAP:ABE-0003015
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0878; htrD
Summary
Translation start site verified by start codon mutagenesis (Cruz-Ramos, 2004). [More information is available at EcoGene: EG11405]. The cydDC operon encodes two ATP-binding cassette (ABC) transporter proteins that are most closely similar to ABC transporters involved in export . [More information is available at EcoCyc: EG11405].
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Genomic context

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Sequence:
NC_000913.3 (929196..930962, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene leucyl/phenylalanyl-tRNA--protein transferase Neighboring gene glutathione/L-cysteine ABC exporter subunit CydC Neighboring gene thioredoxin reductase Neighboring gene DNA-binding transcriptional dual regulator Lrp

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations affecting the cytochrome d-containing oxidase complex of Escherichia coli K12: identification and mapping of a fourth locus, cydD. Poole RK, et al. J Gen Microbiol, 1989 Jul. PMID 2559153
  2. Investigation of the role of the cydD gene product in production of a functional cytochrome d oxidase in Escherichia coli. Bebbington KJ, et al. FEMS Microbiol Lett, 1993 Aug 15. PMID 8405944
  3. CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress. Holyoake LV, et al. Biochem J, 2016 Mar 15. PMID 26699904, Free PMC Article
  4. Isolation and characterization of the Escherichia coli htrD gene, whose product is required for growth at high temperatures. Delaney JM, et al. J Bacteriol, 1992 Feb. PMID 1310500, Free PMC Article
  5. Identification of the cydC locus required for expression of the functional form of the cytochrome d terminal oxidase complex in Escherichia coli. Georgiou CD, et al. J Bacteriol, 1987 May. PMID 3032907, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ABC-type heme transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled lipid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell redox homeostasis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cysteine export across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cysteine export across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cysteine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cytochrome biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glutathione transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutathione transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in heme transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ATP-binding cassette (ABC) transporter complex, integrated substrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutathione/L-cysteine ABC exporter subunit CydD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    929196..930962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415407.1 glutathione/L-cysteine ABC exporter subunit CydD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415407.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EA12
    Conserved Domains (1) summary
    PRK11174
    Location:1 → 588
    PRK11174; cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed
Nucleotide Protein
Heading Accession and Version

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