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lrp DNA-binding transcriptional dual regulator Lrp [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949051, updated on 23-Apr-2026
Official Symbol
lrp
Official Full Name
DNA-binding transcriptional dual regulator Lrp
Primary source
ECOCYC:EG10547
Locus tag
b0889
See related
ASAP:ABE-0003023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
alsB; ECK0880; ihb; livR; lrs; lss; lstR; mbf; oppI; rblA
Summary
Feast/famine regulatory protein. [More information is available at EcoGene: EG10547]. The Lrp protein belongs to the AsnC family. [More information is available at EcoCyc: EG10547].
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Sequence:
NC_000913.3 (932595..933089)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene heme ABC transporter subunit CydD Neighboring gene thioredoxin reductase Neighboring gene cell division DNA translocase FtsK Neighboring gene outer membrane lipoprotein carrier protein

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The leucine-responsive regulatory protein (Lrp) from Escherichia coli. Stoichiometry and minimal requirements for binding to DNA. Cui Y, et al. J Biol Chem, 1996 Mar 22. PMID 8636076
  2. Acetohydroxy acid synthase isoenzymes of Escherichia coli K-12: a trans-acting regulatory locus of ilvHI gene expression. Ursini MV, et al. Mol Gen Genet, 1981. PMID 7022128
  3. Leucine-responsive regulatory protein plays dual roles as both an activator and a repressor of the Escherichia coli pap fimbrial operon. van der Woude MW, et al. Mol Microbiol, 1995 Jul. PMID 7494479
  4. A consensus sequence for binding of Lrp to DNA. Cui Y, et al. J Bacteriol, 1995 Sep. PMID 7665463, Free PMC Article
  5. Incorporating prior information via shrinkage: a combined analysis of genome-wide location data and gene expression data. Xie Y, et al. Stat Med, 2007 May 10. PMID 16958153

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The overall regulatory behavior of Lrp, which as the authors now show extends to 38% of Escherichia coli genes directly or indirectly under at least one condition, thus arises from the interaction between changes in Lrp binding specificity and cooperative action with other regulators.
    Title: Escherichia coli Lrp Regulates One-Third of the Genome via Direct, Cooperative, and Indirect Routes.
  2. the gene expression of the alaE is regulated by Lrp in response to intracellular levels of l-alanine, which eventually leads to intracellular homeostasis of l-alanine concentrations
    Title: Expression of the alaE gene is positively regulated by the global regulator Lrp in response to intracellular accumulation of l-alanine in Escherichia coli.
  3. These results suggest that the preferential OFF state observed in CS31A cells is mainly due to the weak interaction of the leucine-responsive regulatory protein with the clp distal region and that the PapI homolog favors the OFF phase.
    Title: Leucine-responsive regulatory protein Lrp and PapI homologues influence phase variation of CS31A fimbriae.
  4. MicF activates genes in the Lrp regulon by repressing Lrp, and causes impaired growth in minimal medium.
    Title: A mixed double negative feedback loop between the sRNA MicF and the global regulator Lrp.
  5. we identified two nucleotides (T490, G508) surrounding the Lrp binding site 1 that are critical to maintaining a high OFF to ON switch rate during F1651 phase variation, as well as switching Pap fimbriae towards the OFF state.
    Title: Lrp-DNA complex stability determines the level of ON cells in type P fimbriae phase variation.
  6. The N-terminal tail plays a significant role in modulating Lrp function in DNA recognition.
    Title: Recognition of DNA by the helix-turn-helix global regulatory protein Lrp is modulated by the amino terminus.
  7. These results indicate that ArgP is a major regulator of lysP expression but that Lrp modulates lysP transcription under lysine-limiting conditions.
    Title: Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli.
  8. Binding of the IHF protein to a site immediately adjacent to fimS is required for phase-on orientational bias; in the absence of LRP and IHF binding, fimS adopts the off orientation and the H-NS protein is required to maintain this orientational bias.
    Title: DNA relaxation-dependent phase biasing of the fim genetic switch in Escherichia coli depends on the interplay of H-NS, IHF and LRP.
  9. Activation by Lrp interferes with the previously demonstrated activation of the argO promoter by ArgP.
    Title: Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP.
  10. the regulatory motifs for different amino acid fall into the traditional classification of amino acid families, thus elucidating the structure and physiological functions of the Lrp-regulon
    Title: Genome-scale reconstruction of the Lrp regulatory network in Escherichia coli.
Submit: New GeneRIF Correction See all GeneRIFs (19)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA-binding transcription activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription activator activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription repressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription repressor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-alanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to L-leucine IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to L-leucine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-DNA complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
DNA-binding transcriptional dual regulator Lrp

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    932595..933089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415409.1 DNA-binding transcriptional dual regulator Lrp

    See identical proteins and their annotated locations for NP_415409.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q14F19
    Conserved Domains (1) summary
    PRK11169
    Location:1 → 164
    PRK11169; leucine-responsive transcriptional regulator Lrp
Nucleotide Protein
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