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preT dihydropyrimidine dehydrogenase (NAD(+)) subunit PreT [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949049, updated on 4-Feb-2026
Official Symbol
preT
Official Full Name
dihydropyrimidine dehydrogenase (NAD(+)) subunit PreT
Primary source
ECOCYC:G7145
Locus tag
b2146
See related
ASAP:ABE-0007096
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2139; yeiT
Summary
AFMB Structural Genomics target Number 63 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG14074]. Based on sequence similarity, YeiT is predicted to be a dihydrothymine dehydrogenase . [More information is available at EcoCyc: G7145].
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Sequence:
NC_000913.3 (2234033..2235271)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF218 domain-containing protein SanA Neighboring gene DUF2542 domain-containing protein YeiS Neighboring gene dihydropyrimidine dehydrogenase (NAD(+)) subunit PreA Neighboring gene D-galactose/methyl-galactoside ABC transporter membrane subunit Neighboring gene D-galactose/methyl-galactoside ABC transporter ATP binding subunit

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Overexpression and characterization of Escherichia coli dihydropyrimidine dehydrogenase: a four iron-sulphur cluster containing flavoprotein. Yoshioka H, et al. J Biochem, 2021 Dec 4. PMID 34097066
  2. Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil. Hidese R, et al. J Bacteriol, 2011 Feb. PMID 21169495, Free PMC Article
  3. The iscS gene deficiency affects the expression of pyrimidine metabolism genes. Mihara H, et al. Biochem Biophys Res Commun, 2008 Aug 1. PMID 18482579
  4. Global gene expression in Escherichia coli biofilms. Schembri MA, et al. Mol Microbiol, 2003 Apr. PMID 12657059
  5. Flavoprotein disulfide reductases: advances in chemistry and function. Argyrou A, et al. Prog Nucleic Acid Res Mol Biol, 2004. PMID 15210329

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
contributes_to 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADH dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to dihydropyrimidine dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydropyrimidine dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in pyrimidine nucleobase catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thymine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uracil catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of dihydropyrimidine dehydrogenase (NAD+) complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
dihydropyrimidine dehydrogenase (NAD(+)) subunit PreT
NP_416651.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2234033..2235271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416651.1 dihydropyrimidine dehydrogenase (NAD(+)) subunit PreT

    See identical proteins and their annotated locations for NP_416651.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376U6U7, A0A8S7I0R1
    Conserved Domains (1) summary
    PRK11749
    Location:3 → 412
    PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional
Nucleotide Protein
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