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waaA KDO transferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949048, updated on 26-Mar-2025
Official Symbol
waaA
Official Full Name
KDO transferase
Primary source
ECOCYC:EG10520
Locus tag
b3633
See related
ASAP:ABE-0011873
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3623; kdtA
Summary
WaaA adds 2 Kdo residues to lipid IVA. waaA is an essential gene. [More information is available at EcoGene: EG10520]. The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG10520].
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Sequence:
NC_000913.3 (3808540..3809817)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipopolysaccharide glucosyltransferase I Neighboring gene lipopolysaccharide core heptosyltransferase 3 Neighboring gene ncRNA Neighboring gene pantetheine-phosphate adenylyltransferase Neighboring gene DNA-formamidopyrimidine glycosylase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli. Emiola A, et al. Proc Natl Acad Sci U S A, 2016 Mar 15. PMID 26929331, Free PMC Article
  2. Biosynthesis of lipopolysaccharide in Escherichia coli. Cytoplasmic enzymes that attach 3-deoxy-D-manno-octulosonic acid to lipid A. Brozek KA, et al. J Biol Chem, 1989 Apr 25. PMID 2651435
  3. Inhibition of lipopolysaccharide biosynthesis and cell growth following inactivation of the kdtA gene in Escherichia coli. Belunis CJ, et al. J Biol Chem, 1995 Nov 17. PMID 7499229
  4. Dual role of FtsH in regulating lipopolysaccharide biosynthesis in Escherichia coli. Katz C, et al. J Bacteriol, 2008 Nov. PMID 18776015, Free PMC Article
  5. Replacement of lipopolysaccharide with free lipid A molecules in Escherichia coli mutants lacking all core sugars. Reynolds CM, et al. Biochemistry, 2009 Oct 13. PMID 19754149, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables Kdo transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Kdo2-lipid A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid A biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide core region biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Preferred Names
KDO transferase
NP_418090.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3808540..3809817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418090.1 KDO transferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418090.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7D7KC07
    Conserved Domains (1) summary
    PRK05749
    Location:1 → 424
    PRK05749; 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed
Nucleotide Protein
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