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dfp fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949047, updated on 3-Dec-2024

Summary

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Official Symbol
dfp
Official Full Name
fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase
Primary source
ECOCYC:EG10004
Locus tag
b3639
See related
ASAP:ABE-0011896
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
coaBC; ECK3629
Summary
Dfp was originally identified as a flavoprotein affecting DNA synthesis and pantothenate metabolism. [More information is available at EcoGene: EG10004]. The dfp (coaBC) gene encodes a bifunctional protein that catalyzes two sequential reactions in the coenzyme A biosynthetic pathway . [More information is available at EcoCyc: EG10004].
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Genomic context

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Sequence:
NC_000913.3 (3812731..3813951)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal subunit protein L28 Neighboring gene RadC-like JAB domain-containing protein YicR Neighboring gene dUTP diphosphatase Neighboring gene nucleoid occlusion factor SlmA Neighboring gene orotate phosphoribosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa. Balibar CJ, et al. J Bacteriol, 2011 Jul. PMID 21551303, Free PMC Article
  2. Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis. Kupke T, et al. J Biol Chem, 2000 Oct 13. PMID 10922366
  3. Molecular characterization of the 4'-phosphopantothenoylcysteine decarboxylase domain of bacterial Dfp flavoproteins. Kupke T. J Biol Chem, 2001 Jul 20. PMID 11358972
  4. Mechanistic studies on phosphopantothenoylcysteine decarboxylase. Strauss E, et al. J Am Chem Soc, 2001 Jul 4. PMID 11427085
  5. Stereochemical studies on phosphopantothenoylcysteine decarboxylase from Escherichia coli. Strauss E, et al. Bioorg Med Chem Lett, 2003 Feb 10. PMID 12565925

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CoaB exists in an equilibrium of monomers and dimers in solution, with dimer formation being favored in the presence of CTP.
    Title: Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility-mass spectrometry.
  2. The essentiality of coaBC, a single gene encoding a bifunctional protein catalyzing two consecutive steps in the CoA pathway converting 4'-phosphopantothenate to 4'-phosphopantetheine, was confirmed in Escherichia coli.
    Title: Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase
NP_418096.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3812731..3813951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418096.4 fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418096.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAQ2R9Z4
    Conserved Domains (1) summary
    PRK05579
    Location:1 → 402
    PRK05579; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
Nucleotide Protein
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Gene LinkOut

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