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mglB D-galactose/methyl-galactoside ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949041, updated on 6-Jul-2026
Official Symbol
mglB
Official Full Name
D-galactose/methyl-galactoside ABC transporter periplasmic binding protein
Primary source
ECOCYC:EG10593
Locus tag
b2150
See related
ASAP:ABE-0007108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2143
Summary
MglB binds D-galactose and D-glucose and mediates chemotaxis through the Trg chemoreceptor. [More information is available at EcoGene: EG10593]. MglB is the periplasmic binding component of the galactose ABC transporter. [More information is available at EcoCyc: EG10593].
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Sequence:
NC_000913.3 (2239350..2240348, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-galactose/methyl-galactoside ABC transporter membrane subunit Neighboring gene D-galactose/methyl-galactoside ABC transporter ATP binding subunit Neighboring gene DNA-binding transcriptional dual regulator GalS Neighboring gene DUF418 domain-containing protein YeiB

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The amino acid sequence of the D-galactose-binding protein from Escherichia coli B/r. Mahoney WC, et al. J Biol Chem, 1981 May 10. PMID 7012152
  2. A piezoelectric quartz crystal biosensor: the use of two single cysteine mutants of the periplasmic Escherichia coli glucose/galactose receptor as target proteins for the detection of glucose. Carmon KS, et al. Biochemistry, 2004 Nov 9. PMID 15518575
  3. A novel calcium binding site in the galactose-binding protein of bacterial transport and chemotaxis. Vyas NK, et al. Nature, 1987 Jun 18-24. PMID 3600760
  4. The role of calcium in the conformational dynamics and thermal stability of the D-galactose/D-glucose-binding protein from Escherichia coli. Herman P, et al. Proteins, 2005 Oct 1. PMID 16080150
  5. Change in rigidity in the activated form of the glucose/galactose receptor from Escherichia coli: a phenomenon that will be key to the development of biosensors. Sokolov I, et al. Biophys J, 2006 Feb 1. PMID 16284260, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chemotaxis EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within galactose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within methylgalactoside transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer membrane-bounded periplasmic space ISM
Inferred from Sequence Model
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
D-galactose/methyl-galactoside ABC transporter periplasmic binding protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2239350..2240348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416655.1 D-galactose/methyl-galactoside ABC transporter periplasmic binding protein

    See identical proteins and their annotated locations for NP_416655.1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK15395
    Location:2 → 331
    PRK15395; galactose/glucose ABC transporter substrate-binding protein MglB
Nucleotide Protein
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