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folE GTP cyclohydrolase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949040, updated on 19-Jun-2024

Summary

Gene symbol
folE
Gene description
GTP cyclohydrolase 1
Primary source
ASAP:ABE-0007117
Locus tag
b2153
See related
ECOCYC:EG11375
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2146
Summary
Although a folE null mutant could not be made by Baba (2006), leading to its inclusion in the set of 303 essential genes, Klaus (2005) were able to construct a deletion mutation in folE. [More information is available at EcoGene: EG11375]. GTP cyclohydrolase I is an allosteric enzyme that catalyzes the first step in the biosynthesis of tetrahydrofolate . [More information is available at EcoCyc: EG11375].
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Genomic context

Sequence:
NC_000913.3 (2242984..2243652, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator GalS Neighboring gene DUF418 domain-containing protein YeiB Neighboring gene S-formylglutathione hydrolase/S-lactoylglutathione hydrolase Neighboring gene iron-catecholate outer membrane transporter CirA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP cyclohydrolase I activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP cyclohydrolase I activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP cyclohydrolase I activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within queuosine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tetrahydrobiopterin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GTP cyclohydrolase 1
NP_416658.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2242984..2243652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416658.1 GTP cyclohydrolase 1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416658.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    B3VI29
    Conserved Domains (1) summary
    cl00263
    Location:40220
    TFold; Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl ...