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thyA thymidylate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949035, updated on 19-Sep-2024

Summary

Official Symbol
thyA
Official Full Name
thymidylate synthase
Primary source
ECOCYC:EG11002
Locus tag
b2827
See related
ASAP:ABE-0009268
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2823
Summary
Thymidylate synthase (TS) catalytic mechanism order: [More information is available at EcoGene: EG11002]. Thymidylate synthase plays a key role in DNA synthesis. [More information is available at EcoCyc: EG11002].
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Genomic context

Sequence:
NC_000913.3 (2964361..2965155, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdC Neighboring gene DUF2509 domain-containing protein YgdB Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdB Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdA Neighboring gene phosphatidylglycerol--prolipoprotein diacylglyceryl transferase Neighboring gene phosphoenolpyruvate-protein phosphotransferase PtsP

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thymidylate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thymidylate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thymidylate synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in dTMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within dTMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dTMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in dTTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thymidylate synthase
NP_417304.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2964361..2965155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417304.1 thymidylate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417304.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AFL3, A0A8S7S4C6
    Conserved Domains (1) summary
    PRK01827
    Location:1264
    thyA; thymidylate synthase; Reviewed