U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

focB formate channel FocB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949032, updated on 30-Jul-2025
Official Symbol
focB
Official Full Name
formate channel FocB
Primary source
ECOCYC:G7309
Locus tag
b2492
See related
ASAP:ABE-0008206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2488
Summary
FocB is a putative formate transporter, belonging to the FNT family of formate and nitrite transporters . [More information is available at EcoCyc: G7309].
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (2613934..2614782)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 4 catalytic subunit HyfI Neighboring gene putative hydrogenase 4 assembly protein Neighboring gene DNA-binding transcriptional activator HyfR Neighboring gene putative transporter YfgO Neighboring gene beta-barrel assembly-enhancing protease

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure of FocB--a member of a family of transcription factors regulating fimbrial adhesin expression in uropathogenic Escherichia coli. Hultdin UW, et al. FEBS J, 2010 Aug. PMID 20646069
  2. Purification, crystallization and preliminary data analysis of FocB, a transcription factor regulating fimbrial adhesin expression in uropathogenic Escherichia coli. Hultdin UW, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Mar 1. PMID 20208176, Free PMC Article
  3. Role of the Escherichia coli FocA and FocB formate channels in controlling proton/potassium fluxes and hydrogen production during osmotic stress in energy-limited, stationary phase fermenting cells. Babayan A, et al. Biochimie, 2024 Jun. PMID 38307245
  4. pH and a mixed carbon-substrate spectrum influence FocA- and FocB-dependent, formate-driven H2 production in Escherichia coli. Hakobyan B, et al. FEMS Microbiol Lett, 2018 Nov 1. PMID 30247527
  5. Phylogenetic characterization of novel transport protein families revealed by genome analyses. Saier MH Jr, et al. Biochim Biophys Acta, 1999 Feb 25. PMID 10082980

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of the Escherichia coli FocA and FocB formate channels in controlling proton/potassium fluxes and hydrogen production during osmotic stress in energy-limited, stationary phase fermenting cells.
    Title: Role of the Escherichia coli FocA and FocB formate channels in controlling proton/potassium fluxes and hydrogen production during osmotic stress in energy-limited, stationary phase fermenting cells.
  2. Our results suggest that regulation of formate translocation direction by FocA/FocB channels is important for maintaining internal pH and proton motive force by modulating H2 production.
    Title: pH and a mixed carbon-substrate spectrum influence FocA- and FocB-dependent, formate-driven H2 production in Escherichia coli.
  3. To elucidate the detailed function of FocB, they have determined its crystal structure at 1.4 A resolution. FocB is an all alpha-helical protein with a helix-turn-helix motif.
    Title: Structure of FocB--a member of a family of transcription factors regulating fimbrial adhesin expression in uropathogenic Escherichia coli.
  4. FocB was crystallized using the hanging-drop vapour-diffusion method at 295 K. A native data set to 2.0 A resolution was collected at 100 K using synchrotron radiation
    Title: Purification, crystallization and preliminary data analysis of FocB, a transcription factor regulating fimbrial adhesin expression in uropathogenic Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables formate transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables formate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within formate transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in formate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mixed acid fermentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
Preferred Names
formate channel FocB

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2613934..2614782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416987.1 formate channel FocB

    See identical proteins and their annotated locations for NP_416987.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6C9QC39
    Conserved Domains (1) summary
    PRK09713
    Location:1 → 281
    focB; formate transporter
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.