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purE N(5)-carboxyaminoimidazole ribonucleotide mutase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949031, updated on 30-Jul-2025
Official Symbol
purE
Official Full Name
N(5)-carboxyaminoimidazole ribonucleotide mutase
Primary source
ECOCYC:EG10793
Locus tag
b0523
See related
ASAP:ABE-0001796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ade; ade(f); ade3; ECK0516; Pur2
Summary
PurE was previously thought to be the catalytic subunit of phosphoribosylaminoimidazole carboxylase, with ATPase subunit PurK (Tiedeman, 1989). [More information is available at EcoGene: EG10793]. PurK and PurE were previously thought to be two subunits of AIR carboxylase , though more recent studies have shown the enzymes to be subunits of a distinct carboxylase and mutase, respectively . [More information is available at EcoCyc: EG10793].
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Sequence:
NC_000913.3 (552591..553100, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1116 domain-containing protein YlbE Neighboring gene DUF2877 domain-containing protein YlbF Neighboring gene putative carbamate kinase Neighboring gene 5-(carboxyamino)imidazole ribonucleotide synthase Neighboring gene UDP-2,3-diacylglucosamine diphosphatase Neighboring gene peptidyl-prolyl cis-trans isomerase B

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Molecular cloning and characterization of the purE operon of Escherichia coli. Kamholz J, et al. Gene, 1986. PMID 3021590
  2. A DNA-binding protein with specificity for pur genes in Escherichia coli. Koduri RK, et al. J Biol Chem, 1980 Oct 25. PMID 7000760
  3. Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms. Firestine SM, et al. Biochemistry, 1994 Oct 4. PMID 7918411
  4. N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli. Mueller EJ, et al. Biochemistry, 1994 Mar 1. PMID 8117684
  5. Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway. Meyer E, et al. Biochemistry, 1992 Jun 2. PMID 1534690

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 5-(carboxyamino)imidazole ribonucleotide mutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5-(carboxyamino)imidazole ribonucleotide mutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5-(carboxyamino)imidazole ribonucleotide mutase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
N(5)-carboxyaminoimidazole ribonucleotide mutase
NP_415056.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    552591..553100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415056.1 N(5)-carboxyaminoimidazole ribonucleotide mutase

    See identical proteins and their annotated locations for NP_415056.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A192CJ04, A0AA36KV36
    Conserved Domains (1) summary
    COG0041
    Location:6 → 169
    PurE; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]
Nucleotide Protein
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